INT83407

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Context Info
Confidence 0.58
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 0.90
Pain Relevance 4.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gucy1b2) ion binding (Gucy1b2) cytoplasm (Gucy1b2)
Anatomy Link Frequency
neurons 2
brain 2
Gucy1b2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 5 99.64 Very High Very High Very High
Intracerebroventricular 13 99.14 Very High Very High Very High
Morphine 8 98.76 Very High Very High Very High
withdrawal 10 98.40 Very High Very High Very High
Analgesic 17 97.92 Very High Very High Very High
tolerance 14 97.20 Very High Very High Very High
tramadol 22 97.08 Very High Very High Very High
Neuronal nitric oxide synthase 5 96.44 Very High Very High Very High
Locus ceruleus 4 94.96 High High
Glutamate 1 93.12 High High
Disease Link Frequency Relevance Heat
Stress 4 99.96 Very High Very High Very High
Opiate Addiction 2 91.24 High High
Injury 9 91.00 High High
Substance Withdrawal Syndrome 1 90.04 High High
Attention Deficit Hyperactivity Disorder 2 87.20 High High
Nociception 17 71.12 Quite High
Natriuresis 3 69.12 Quite High
INFLAMMATION 22 59.92 Quite High
Depressive Disorder 2 53.44 Quite High
Headache 15 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sevoflurane itself also dose-dependently decreased cGMP contents in brain in vivo and inhibited the NO-stimulated sGC activity in vitro.
Negative_regulation (inhibited) of sGC in brain
1) Confidence 0.58 Published 1999 Journal Anesth. Analg. Section Abstract Doc Link 10439772 Disease Relevance 0.07 Pain Relevance 0.39
We sought to determine the involvement of inhibition of soluble guanylyl cyclase (sGC) in the anesthetic mechanism and site of action of volatile anesthetics.
Negative_regulation (inhibition) of sGC
2) Confidence 0.58 Published 1999 Journal Anesth. Analg. Section Abstract Doc Link 10439772 Disease Relevance 0 Pain Relevance 0.22
In this study, the effect of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), a highly selective sGC inhibitor, on the naloxone-precipitated morphine withdrawal was examined using differential normal pulse voltammetry (DNPV) to measure LC activity, in vivo microdialysis to measure glutamate/aspartate release response, and behavioural assessment to evaluate withdrawal symptoms.
Negative_regulation (inhibitor) of sGC associated with glutamate, locus ceruleus, narcan, withdrawal and morphine
3) Confidence 0.43 Published 2000 Journal Brain Res. Section Abstract Doc Link 10720614 Disease Relevance 0.34 Pain Relevance 1.03
We examined the effect of intracerebroventricular (ICV) administration of methylene blue (MB), a sGC inhibitor, on the minimum alveolar anesthetic concentration (MAC) of sevoflurane and the brain cGMP content in rats in vivo.
Negative_regulation (inhibitor) of sGC in brain associated with intracerebroventricular
4) Confidence 0.42 Published 1999 Journal Anesth. Analg. Section Abstract Doc Link 10439772 Disease Relevance 0 Pain Relevance 0.32
Pretreatment of animals with methylene blue (3.75 mg/kg i.p., an inhibitor of NO synthase and soluble guanylate cyclase - sGC) or (1H-[1,2,4] oxadiazolo[4,3-a]quinoxalin-1-one) (ODQ, 2 mg/kg, i.p., a specific inhibitor of sGC) significantly caused a synergistic effect with a sub-effective dose of tramadol (5 mg/kg, p.o.) in the FST.
Negative_regulation (inhibitor) of sGC associated with tramadol
5) Confidence 0.34 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 18773934 Disease Relevance 0.05 Pain Relevance 1.07
Pretreatment of animals with methylene blue (3.75 mg/kg i.p., an inhibitor of NO synthase and soluble guanylate cyclase - sGC) or (1H-[1,2,4] oxadiazolo[4,3-a]quinoxalin-1-one) (ODQ, 2 mg/kg, i.p., a specific inhibitor of sGC) significantly caused a synergistic effect with a sub-effective dose of tramadol (5 mg/kg, p.o.) in the FST.
Negative_regulation (inhibitor) of sGC associated with tramadol
6) Confidence 0.34 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 18773934 Disease Relevance 0 Pain Relevance 0.92
We additionally showed that inhibition of sGC and PKG fails to block the activation by NO, indicating that NO signaling is not through the classical indirect pathway (Figure 10).
Negative_regulation (inhibition) of sGC
7) Confidence 0.20 Published 2009 Journal Mol Pain Section Body Doc Link PMC2673211 Disease Relevance 0 Pain Relevance 0
If DRG neurons lack sGC and the capacity to mobilize the NO/sGC/cGMP pathway, it is likely that S-nitrosylation is the only mechanism by which NO activates KATP channels in these cells. nNOS expression in DRG neurons is markedly up-regulated after injury, especially in the small and medium sized neuronal population, enabling these neurons to produce endogenous NO [50,51].
Negative_regulation (lack) of sGC in neurons associated with injury
8) Confidence 0.20 Published 2009 Journal Mol Pain Section Body Doc Link PMC2673211 Disease Relevance 0.09 Pain Relevance 0.03
Our finding that NO/sGC/cGMP is inactive in DRG cells is consistent with reports indicating the absence of sGC in mice [45] and cGMP in rat DRG neurons [46] using immunohistochemical techniques.
Negative_regulation (absence) of sGC in neurons
9) Confidence 0.20 Published 2009 Journal Mol Pain Section Body Doc Link PMC2673211 Disease Relevance 0.07 Pain Relevance 0
M, the sGC inhibitor NS2028 significantly reduced the stimulatory effect of DETA/NO (Fig. 4A).
Negative_regulation (inhibitor) of sGC
10) Confidence 0.10 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731738 Disease Relevance 0.17 Pain Relevance 0.12
Physiological Implications¬óNitrate tolerance is a complex
and almost certainly multifactorial phenomenon, with potential contributions
from impaired bioactivation, oxidative stress, sGC desensitization, and
physiological counter-regulation
(3,
6,
14,
15). 
Negative_regulation (desensitization) of sGC associated with stress and tolerance
11) Confidence 0.04 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0.10 Pain Relevance 0.11

General Comments

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