INT83419

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Context Info
Confidence 0.68
First Reported 1999
Last Reported 2010
Negated 5
Speculated 3
Reported most in Body
Documents 57
Total Number 65
Disease Relevance 12.11
Pain Relevance 63.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 8
brain 7
spinal cord 4
embryonic kidney 3
dendrites 2
Mors1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 3087 100.00 Very High Very High Very High
opioid receptor 2670 100.00 Very High Very High Very High
mu opioid receptor 1071 100.00 Very High Very High Very High
Delta opioid receptors 5 100.00 Very High Very High Very High
narcan 844 99.92 Very High Very High Very High
Dorsal horn 100 99.84 Very High Very High Very High
tolerance 1058 99.78 Very High Very High Very High
Antinociceptive 646 99.72 Very High Very High Very High
Ventral tegmentum 8 99.68 Very High Very High Very High
Spinal cord 407 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 184 99.98 Very High Very High Very High
Pain 205 99.60 Very High Very High Very High
Pheochromocytoma 60 99.48 Very High Very High Very High
Colon Cancer 6 99.40 Very High Very High Very High
Neuroblastoma 21 99.24 Very High Very High Very High
Stress 21 98.86 Very High Very High Very High
Urological Neuroanatomy 196 98.74 Very High Very High Very High
Injury 62 98.28 Very High Very High Very High
Neuropathic Pain 7 97.68 Very High Very High Very High
Adhesions 16 96.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A similar effect of acute morphine administration was observed for endogenously expressed MORs by immunoelectron microscopy; the acute administration of morphine increased the density of MORs associated with internal membrane structures specifically in dendrites.
Gene_expression (expressed) of MORs in dendrites associated with mu opioid receptor and morphine
1) Confidence 0.68 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12764121 Disease Relevance 0 Pain Relevance 1.59
Morphine stimulates the internalization of mu-opioid receptors (MORs) in transfected cell models to a lesser degree than opioid peptides and other analgesic drugs, such as methadone, and previous studies have reported that morphine does not produce a detectable redistribution of MORs in neural tissue after either acute or chronic administration.
Neg (not) Gene_expression (produce) of MORs in neural associated with analgesic, mu opioid receptor, methadone, opioid and morphine
2) Confidence 0.46 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12764121 Disease Relevance 0 Pain Relevance 1.34
The MORs expressed in HEK 293 cells elude internalization upon exposure to morphine, even if the opioid is incubated for long periods of time at high concentrations [32].
Gene_expression (expressed) of MORs associated with opioid receptor, opioid and morphine
3) Confidence 0.40 Published 2007 Journal Mol Pain Section Body Doc Link PMC1947952 Disease Relevance 0.08 Pain Relevance 1.32
Moreover, our observations in PAG neurons are comparable with those with DAMGO in HEK 293 cells expressing MORs.
Gene_expression (expressing) of MORs in neurons associated with urological neuroanatomy and opioid receptor
4) Confidence 0.35 Published 2007 Journal Mol Pain Section Body Doc Link PMC1947952 Disease Relevance 0.17 Pain Relevance 1.11
These observations suggest that new synthesis of MORs is required to overcome the tolerance that follows an acute dose of morphine.


Gene_expression (synthesis) of MORs associated with tolerance, opioid receptor and morphine
5) Confidence 0.35 Published 2007 Journal Mol Pain Section Body Doc Link PMC1947952 Disease Relevance 0 Pain Relevance 1.77
Accordingly, no substantial internalization of MORs was produced and only a small signal could be immunoprecipitated from the supernatant (Fig. 1).
Gene_expression (produced) of MORs associated with opioid receptor
6) Confidence 0.31 Published 2007 Journal Mol Pain Section Body Doc Link PMC1947952 Disease Relevance 0.19 Pain Relevance 1.32
These areas express MORs [41-44] thus suggesting that eM might be an important homeostatic modulator of their respective functions.
Gene_expression (express) of MORs
7) Confidence 0.31 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017033 Disease Relevance 0.29 Pain Relevance 0.93
MORs present in the brains of STOP null mice were expressed at a higher density and displayed a higher affinity for morphine compared to WT mice.
Gene_expression (present) of MORs in brains associated with morphine
8) Confidence 0.31 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017033 Disease Relevance 0.31 Pain Relevance 0.72
While the MORs recycle rapidly, a proportion of the internalized MORs undergoes endocytic sorting to lysosomes and thus, proteolytic degradation [8,9].
Gene_expression (recycle) of MORs associated with opioid receptor
9) Confidence 0.31 Published 2007 Journal Mol Pain Section Body Doc Link PMC1947952 Disease Relevance 0.09 Pain Relevance 1.45
Moreover, whilst the first dose of morphine caused moderate serine375 phosphorylation of MORs, this second dose promoted notable phosphorylation of the receptors that could be detected both at the surface as well as in the internalized MORs (Fig. 2).
Gene_expression (detected) of MORs associated with opioid receptor and morphine
10) Confidence 0.31 Published 2007 Journal Mol Pain Section Body Doc Link PMC1947952 Disease Relevance 0 Pain Relevance 1.93
In contrast, the MORs present in embryonic cultured neurons were internalized upon incubation with morphine [18].
Gene_expression (present) of MORs in neurons associated with opioid receptor and morphine
11) Confidence 0.31 Published 2007 Journal Mol Pain Section Body Doc Link PMC1947952 Disease Relevance 0.06 Pain Relevance 1.27
Both mu-opioid receptors (MORs) and delta-opioid receptors (DORs) are expressed in the ventral tegmental area (VTA) and are thought to be involved in the addictive properties of opiates.
Gene_expression (expressed) of MORs in ventral associated with ventral tegmentum, mu opioid receptor, opiate and delta opioid receptors
12) Confidence 0.30 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17895918 Disease Relevance 0.05 Pain Relevance 0.89
Endogenous morphine is likely involved in different stress-modulating or pain-modulating mechanisms via binding to MORs which are expressed by numerous cell types (e.g., neurons and immune cells) [21,36-38].
Gene_expression (expressed) of MORs in immune cells associated with stress, pain and morphine
13) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017033 Disease Relevance 0.36 Pain Relevance 1.23
Notably, and in contrast to what is observed in cultured cells, morphine produces some membrane trafficking of the MORs in dendrites of nucleus accumbens neurons and more extensive MOR internalization in embryonic striatal neurons and ganglia neurons [17-19].
Gene_expression (produces) of MORs in neurons associated with nucleus accumbens, opioid receptor and morphine
14) Confidence 0.27 Published 2007 Journal Mol Pain Section Body Doc Link PMC1947952 Disease Relevance 0 Pain Relevance 0.90
DAMGO evaded the first part of this process directly producing the efficient Ser375 phosphorylation and recycling of MORs, which was accompanied by low tolerance to its effects.
Gene_expression (producing) of MORs associated with tolerance and opioid receptor
15) Confidence 0.27 Published 2007 Journal Mol Pain Section Body Doc Link PMC1947952 Disease Relevance 0.13 Pain Relevance 1.16
In both systems, DAMGO produces robust Ser375 phosphorylation and internalization of the MORs whereas in contrast, morphine only weakly induces these processes.
Gene_expression (produces) of MORs associated with opioid receptor and morphine
16) Confidence 0.27 Published 2007 Journal Mol Pain Section Body Doc Link PMC1947952 Disease Relevance 0.09 Pain Relevance 1.75
The Ser-phosphorylated MORs could be detected in the plasma membrane even 24 h after of administration of this second dose of morphine.
Gene_expression (detected) of MORs in plasma associated with opioid receptor and morphine
17) Confidence 0.27 Published 2007 Journal Mol Pain Section Body Doc Link PMC1947952 Disease Relevance 0 Pain Relevance 1.88
Elevated affinity and density of MORs in the brain of STOP null mice
Gene_expression (density) of MORs in brain
18) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017033 Disease Relevance 0.15 Pain Relevance 0.55
MORs present in the brains of STOP null mice were expressed at a higher density and displayed a higher affinity for morphine compared to WT mice.
Gene_expression (expressed) of MORs in brains associated with morphine
19) Confidence 0.24 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017033 Disease Relevance 0.32 Pain Relevance 0.79
The productive binding of morphine to MORs induces the release of free G??
Gene_expression (productive) of MORs associated with morphine
20) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.09

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