INT83422

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Context Info
Confidence 0.12
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 12
Disease Relevance 5.09
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FANCB) extracellular region (IGHG3) nucleus (FANCB)
FANCB (Homo sapiens)
IGHG3 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 22 100.00 Very High Very High Very High
Chronic pancreatitis 50 84.56 Quite High
alcohol 10 78.88 Quite High
Arthritis 10 71.44 Quite High
imagery 30 71.28 Quite High
Pain 4 64.88 Quite High
Inflammation 42 61.44 Quite High
fibrosis 20 5.00 Very Low Very Low Very Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
Prostatitis 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 32 100.00 Very High Very High Very High
Pancreatitis 330 98.48 Very High Very High Very High
Autoimmune Disease 70 95.36 Very High Very High Very High
Disease 110 85.40 High High
Bullous Skin Disease 40 81.68 Quite High
Alcohol Addiction 10 78.88 Quite High
Targeted Disruption 10 60.24 Quite High
Pressure And Volume Under Development 20 53.28 Quite High
Autoimmune Hepatitis 20 52.88 Quite High
Biliary Liver Cirrhosis 20 51.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It should be also reminded that a previous report, albeit in vitro, did show through domain swapping experiments that the binding of a monoclonal IgG4 RF (isolated this time from a rheumatoid arthritis patient) to IgG is through their respective constant segments and not Fab-Fc [40].
Fab Binding (binding) of IgG associated with rheumatoid arthritis
1) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.17 Pain Relevance 0.09
It should be also reminded that a previous report, albeit in vitro, did show through domain swapping experiments that the binding of a monoclonal IgG4 RF (isolated this time from a rheumatoid arthritis patient) to IgG is through their respective constant segments and not Fab-Fc [40].
Fab Binding (binding) of IgG4 associated with rheumatoid arthritis
2) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.17 Pain Relevance 0.09
These results collectively indicate that the Fc portion of IgG4, rather than the Fab portion, binds to IgG Fc, and that the binding of IgG4 to IgG is not attributable to the autoantibody activity of IgG4 i.e. via Fab.
Fab Binding (binds) of IgG
3) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.19 Pain Relevance 0
These results collectively indicate that the Fc portion of IgG4, rather than the Fab portion, binds to IgG Fc, and that the binding of IgG4 to IgG is not attributable to the autoantibody activity of IgG4 i.e. via Fab.
Fab Binding (binding) of IgG4
4) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.35 Pain Relevance 0
The interaction between the RF and IgG is well documented; the RF Fab (antigen binding site) recognizes IgG Fc (constant) segment most frequently at the level of C?
Fab Binding (recognizes) of IgG
5) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.88 Pain Relevance 0.22
Based on the fact that several monoclonal (myeloma) IgG4 proteins do show the capacity to act as RF [39] we aimed to ascertain whether serum (polyclonal) IgG4 in autoimmune pancreatitis, does in fact act as RF, that is commonly defined as an autoantibody which recognizes IgG Fc through its Fab [3].
Fab Binding (recognizes) of IgG associated with pancreatitis
6) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.45 Pain Relevance 0
These results collectively indicate that the Fc portion of IgG4, rather than the Fab portion, binds to IgG Fc, and that the binding of IgG4 to IgG is not attributable to the autoantibody activity of IgG4 i.e. via Fab.
Fab Binding (binding) of IgG
7) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.35 Pain Relevance 0
The interaction between the RF and IgG is well documented; the RF Fab (antigen binding site) recognizes IgG Fc (constant) segment most frequently at the level of C?
Fab Binding (recognizes) of IgG
8) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.88 Pain Relevance 0.22
These results collectively indicate that the Fc portion of IgG4, rather than the Fab portion, binds to IgG Fc, and that the binding of IgG4 to IgG is not attributable to the autoantibody activity of IgG4 i.e. via Fab.
Fab Binding (binding) of IgG
9) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.35 Pain Relevance 0
The interaction between the RF and IgG is well documented; the RF Fab (antigen binding site) recognizes IgG Fc (constant) segment most frequently at the level of C?
Fab Binding (recognizes) of IgG
10) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.88 Pain Relevance 0.22
Possible blocking interactions of APM were explored by computer-assisted docking studies with the model of a complex of an RF Fab with the Fc of a human IgG(4) antibody.
Fab Binding (complex) of IgG
11) Confidence 0.03 Published 1999 Journal J. Mol. Recognit. Section Abstract Doc Link 10777254 Disease Relevance 0.20 Pain Relevance 0.20
Possible blocking interactions of APM were explored by computer-assisted docking studies with the model of a complex of an RF Fab with the Fc of a human IgG(4) antibody.
Fab Binding (complex) of IgG
12) Confidence 0.03 Published 1999 Journal J. Mol. Recognit. Section Abstract Doc Link 10440996 Disease Relevance 0.20 Pain Relevance 0.20

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