INT83425

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Context Info
Confidence 0.21
First Reported 1999
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 4.56
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD40LG, IGHG3) extracellular space (CD40LG) plasma membrane (CD40LG)
Anatomy Link Frequency
brain 1
CD40LG (Homo sapiens)
IGHG3 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 48 98.00 Very High Very High Very High
abdominal pain 1 94.96 High High
Pain 16 93.44 High High
Inflammation 8 90.00 High High
headache 2 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Renal Failure 1 98.72 Very High Very High Very High
Rheumatoid Arthritis 48 98.00 Very High Very High Very High
Thrombocytopenia 1 97.76 Very High Very High Very High
Diarrhoea 1 95.80 Very High Very High Very High
Vomiting 1 95.36 Very High Very High Very High
Abdominal Pain 1 94.96 High High
Fever 3 94.16 High High
Pain 16 89.72 High High
Infection 42 89.04 High High
Malaria 82 88.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The laboratory tests show the presence of Hantavirus specific IgM and IgG which is confirmed by a specific test revealing Puumala serotype as responsible.
IgM Binding (presence) of IgG
1) Confidence 0.21 Published 2008 Journal Rev Med Suisse Section Abstract Doc Link 18672548 Disease Relevance 0.72 Pain Relevance 0.09
In contrast to IgG, IgM with the same cytophilic properties is associated with rosetting and enhanced pathogenicity [44-47].
IgM Binding (associated) of IgG
2) Confidence 0.05 Published 2005 Journal Malar J Section Body Doc Link PMC548665 Disease Relevance 0.24 Pain Relevance 0
This interpretation is most clearly supported by the result of joint analysis of IgM and IgG reactivity to brain proteins, where two distinct principal components appeared.
IgM Spec (appeared) Binding (reactivity) of IgG in brain
3) Confidence 0.05 Published 2005 Journal Malar J Section Body Doc Link PMC548665 Disease Relevance 0.22 Pain Relevance 0
These clinical observations prompted the testing of the inhibition by APM of the binding interactions of human IgM RFs with IgG Fc regions.
IgM Binding (interactions) of IgG
4) Confidence 0.02 Published 1999 Journal J. Mol. Recognit. Section Abstract Doc Link 10440996 Disease Relevance 0.50 Pain Relevance 0.30
Extrapolations of the current results suggest that APM may inhibit the binding of IgG in a substantial proportion of IgM RFs.
IgM Binding (binding) of IgG
5) Confidence 0.02 Published 1999 Journal J. Mol. Recognit. Section Abstract Doc Link 10440996 Disease Relevance 0.16 Pain Relevance 0.22
Extrapolations of the current results suggest that APM may inhibit the binding of IgG in a substantial proportion of IgM RFs.
IgM Binding (binding) of IgG
6) Confidence 0.02 Published 1999 Journal J. Mol. Recognit. Section Abstract Doc Link 10777254 Disease Relevance 0.16 Pain Relevance 0.22
These clinical observations prompted the testing of the inhibition by APM of the binding interactions of human IgM RFs with IgG Fc regions.
IgM Binding (interactions) of IgG
7) Confidence 0.02 Published 1999 Journal J. Mol. Recognit. Section Abstract Doc Link 10777254 Disease Relevance 0.50 Pain Relevance 0.30
Circulating autoimmune complexes of IgM rheumatoid factors (RF) bound to the Fc portions of normal, polyclonal IgG antibodies are frequently present in humans with rheumatoid arthritis (RA).
IgM Binding (bound) of IgG associated with rheumatoid arthritis
8) Confidence 0.02 Published 1999 Journal J. Mol. Recognit. Section Abstract Doc Link 10440996 Disease Relevance 0.42 Pain Relevance 0.25
Circulating autoimmune complexes of IgM rheumatoid factors (RF) bound to the Fc portions of normal, polyclonal IgG antibodies are frequently present in humans with rheumatoid arthritis (RA).
IgM Binding (bound) of IgG associated with rheumatoid arthritis
9) Confidence 0.02 Published 1999 Journal J. Mol. Recognit. Section Abstract Doc Link 10777254 Disease Relevance 0.42 Pain Relevance 0.25
A human (Mez) IgM known to bind octameric peptides derived from the Fc portion of a human IgG(1) antibody was tested for binding of dipeptides by the Pepscan method of combinatorial chemistry.
IgM Binding (bind) of IgG
10) Confidence 0.02 Published 1999 Journal J. Mol. Recognit. Section Abstract Doc Link 10777254 Disease Relevance 0.41 Pain Relevance 0.23
A human (Mez) IgM known to bind octameric peptides derived from the Fc portion of a human IgG(1) antibody was tested for binding of dipeptides by the Pepscan method of combinatorial chemistry.
IgM Binding (bind) of IgG
11) Confidence 0.02 Published 1999 Journal J. Mol. Recognit. Section Abstract Doc Link 10440996 Disease Relevance 0.41 Pain Relevance 0.23
Although still controversial, overall evidence supports the notion that IgG autoantibodies to OxLDL are associated with pro-atherogenic properties and IgM autoantibodies to OxLDL with anti-atherogenic properties [19-21].
IgM Binding (associated) of IgG
12) Confidence 0.00 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2775732 Disease Relevance 0.42 Pain Relevance 0

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