INT83431

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Context Info
Confidence 0.48
First Reported 1999
Last Reported 2010
Negated 6
Speculated 2
Reported most in Body
Documents 35
Total Number 41
Disease Relevance 33.63
Pain Relevance 3.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (ADIPOQ) extracellular space (ADIPOQ) extracellular region (ADIPOQ)
endoplasmic reticulum (ADIPOQ)
Anatomy Link Frequency
plaques 3
heart 3
plasma 2
skeletal muscle 1
coronary artery 1
ADIPOQ (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 348 98.76 Very High Very High Very High
rheumatoid arthritis 40 97.46 Very High Very High Very High
Angina 76 96.20 Very High Very High Very High
chemokine 13 93.12 High High
cytokine 24 87.00 High High
Pain 15 86.96 High High
depression 24 82.24 Quite High
tolerance 9 80.44 Quite High
Inflammatory marker 29 78.60 Quite High
lidocaine 2 50.76 Quite High
Disease Link Frequency Relevance Heat
Obesity 1065 100.00 Very High Very High Very High
Insulin Resistance 297 100.00 Very High Very High Very High
Diabetes Mellitus 286 100.00 Very High Very High Very High
Depression 59 100.00 Very High Very High Very High
Syndrome 8 99.92 Very High Very High Very High
Disorder Of Lipid Metabolism 306 99.80 Very High Very High Very High
Cardiovascular Disease 68 99.80 Very High Very High Very High
Myocardial Infarction 173 99.76 Very High Very High Very High
Death 71 99.40 Very High Very High Very High
Atherosclerosis 132 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adiponectin is inversely associated with mixed and non-calcified coronary artery plaques
Adiponectin Binding (associated) of in plaques
1) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 1.04 Pain Relevance 0
Although the exact mechanisms of the negative association between adiponectin and mixed and non-calcified plaques remain to be determined, several possible explanations should be considered.
adiponectin Neg (negative) Binding (association) of in plaques
2) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 0.54 Pain Relevance 0.04
Apart from being determined by female sex (1.34-fold, p<0.001), serum
   adiponectin was significantly associated not with obesity measures. 
adiponectin Binding (associated) of associated with obesity
3) Confidence 0.43 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 0.78 Pain Relevance 0.04
In humans, however, conflicting results have been reported between serum adiponectin
   and coronary heart disease (CHD) 1-3 in one of which 3 was suggested that
   there may be a true sex difference in the association of adiponectin with coronary heart
   disease. 
adiponectin Binding (association) of in heart associated with disease and coronary heart disease
4) Confidence 0.38 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 0.88 Pain Relevance 0.12
Recent data have also indicated that an individual's sex may modify the association between adiponectin and age (43).
adiponectin Binding (association) of
5) Confidence 0.38 Published 2010 Journal Diabetes Section Body Doc Link PMC2797949 Disease Relevance 0.80 Pain Relevance 0.18
To determine whether storage conditions may have affected adiponectin levels, adiponectin concentrations in aliquots stored for 21 and 33 months at ?
adiponectin Binding (concentrations) of
6) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 0.67 Pain Relevance 0
Interestingly, adiponectin was negatively correlated with PAT volume (r?
adiponectin Binding (Interestingly) of associated with heart rate under development
7) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 1.07 Pain Relevance 0.07
Therefore, the finding of an independent association between adiponectin and non-calcified and mixed coronary plaques may have important therapeutic and preventive implications for decreasing the risk of acute coronary events.
adiponectin Binding (association) of in plaques
8) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 0.56 Pain Relevance 0.03
Our study also showed significant association between adiponectin levels in patients with ST elevation MI and non-ST elevation MI in spite of their different pathophysiology [23,24].
adiponectin Binding (association) of associated with myocardial infarction
9) Confidence 0.37 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2694800 Disease Relevance 1.70 Pain Relevance 0.19
Correlations and associations between adiponectin and cardiovascular risk factors
adiponectin Binding (associations) of
10) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 0.94 Pain Relevance 0.08
Although some studies [30,31] showed increased adiponectin level in patients with renal dysfunction but our study showed as the same of Shibata et al. [32] that there is no association between adiponectin and renal function in atherosclerotic patients with normal renal function.
adiponectin Neg (no) Binding (association) of associated with atherosclerosis and renal disease
11) Confidence 0.36 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2694800 Disease Relevance 0.68 Pain Relevance 0
Moreover, the theoretical hypothesis of 'adiponectin resistance' was put forward due to
   the observation of a positive association of plasma adiponectin concentration and age in men,
   and it was conjectured whether the implication of hypoadiponectinemia in youth might be
   different from old age 4. 
adiponectin Binding (association) of in plasma
12) Confidence 0.34 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 0.98 Pain Relevance 0.16
Thus, the aim of this study was to evaluate: 1) the nature and linearity of the association
   between different indicators of obesity and serum adiponectin levels, 2) whether or not
   anticipated inverse associations between adiponectin and HDL-cholesterol, triglycerides/apo B
   and CRP exist independent of BMI or waist circumference, 3) whether SHBG plays an independent
   role on concentrations of adiponectin in Turkish men and women in whom both atherogenic
   dyslipidemia and MetS prevail 11.


adiponectin Binding (associations) of associated with obesity and disorder of lipid metabolism
13) Confidence 0.34 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 1.02 Pain Relevance 0.09
In conclusion, we found that circulating adiponectin, not linearly
    associated with measures of overall or abdominal obesity, disclosed a lack of (independent)
    association with obesity measures and a threshold effect. 
adiponectin Binding (associated) of associated with obesity and metabolic syndrome
14) Confidence 0.34 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 0.76 Pain Relevance 0.07
In studying a large sample of patients with
    coronary heart disease, van Eynatten et al. 26 found a
    lack of association of adiponectin with CRP which they attributed to a potential decrease of
    the role of systemic inflammation as part of the relationship of adiponectin with
    atherosclerosis during the course of the disease.
adiponectin Binding (association) of in heart associated with inflammation, disease, increased venous pressure under development and coronary heart disease
15) Confidence 0.34 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 1.42 Pain Relevance 0.11
Impaired interaction with one of the known or unknown adiponectin receptors enhanced by low
    SHBG might be hypothesized as an underlying mechanism, perhaps with resulting interaction
    between adiponectin and apo B. 
adiponectin Neg (Impaired) Spec (might) Binding (interaction) of
16) Confidence 0.34 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 1.40 Pain Relevance 0.20
The latter type of anti-inflammatory
    properties manifested herein by significant independent associations between adiponectin levels
    and CRP or HDL among men. 
adiponectin Binding (associations) of associated with inflammation and disorder of lipid metabolism
17) Confidence 0.34 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 1.32 Pain Relevance 0.22
Impaired interaction with one of the known or unknown adiponectin receptors enhanced by low
    SHBG might be hypothesized as an underlying mechanism, perhaps with resulting interaction
    between adiponectin and apo B. 
adiponectin Binding (interaction) of
18) Confidence 0.34 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 1.40 Pain Relevance 0.19
Taken together, these findings show a lack of a linear association of adiponectin
    with (abdominal) obesity measures, and levels fail to be reduced in response to increasing
    adiposity.
adiponectin Binding (association) of associated with obesity
19) Confidence 0.32 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 0.55 Pain Relevance 0
Synthesis and secretion of adiponectin by adipocytes, or interaction with specific
    adiponectin receptors might be impaired in obese individuals. 
adiponectin Binding (interaction) of in adipocytes associated with obesity
20) Confidence 0.32 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 0.63 Pain Relevance 0.03

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