INT83442

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Context Info
Confidence 0.57
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 9.51
Pain Relevance 5.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (MIF) cell proliferation (MIF) extracellular space (MIF)
extracellular region (MIF) cytoplasm (MIF)
Anatomy Link Frequency
plasma 1
macrophage 1
brain 1
skeleton 1
bile 1
MIF (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 12 99.82 Very High Very High Very High
aspirin 6 99.50 Very High Very High Very High
Inflammation 195 98.28 Very High Very High Very High
Bile 5 98.20 Very High Very High Very High
cytokine 179 95.04 Very High Very High Very High
Paracetamol 12 94.64 High High
Lasting pain 7 91.52 High High
withdrawal 1 86.96 High High
Opioid 6 86.52 High High
Neuropathic pain 1 86.08 High High
Disease Link Frequency Relevance Heat
Pain 12 99.82 Very High Very High Very High
Myalgia 11 99.52 Very High Very High Very High
Malignant Neoplastic Disease 10 98.86 Very High Very High Very High
INFLAMMATION 210 98.28 Very High Very High Very High
Skin Cancer 9 97.64 Very High Very High Very High
Ovarian Cancer 8 96.88 Very High Very High Very High
Cancer 25 96.56 Very High Very High Very High
Necrosis 4 94.24 High High
Purpura 6 93.84 High High
Skin Diseases 4 93.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hence, small molecule inhibitors of MIF are relentlessly sought as potential anti-inflammatory (antitumour) agents, while a true in vivo substrate for MIF still remains unidentified.
Negative_regulation (inhibitors) of MIF associated with inflammation
1) Confidence 0.57 Published 2009 Journal Curr. Med. Chem. Section Abstract Doc Link 19275614 Disease Relevance 0.53 Pain Relevance 0.27
MIF was similarly reduced after each exercise session (p < 0.05).
Negative_regulation (reduced) of MIF
2) Confidence 0.57 Published 2004 Journal Fiziol Cheloveka Section Abstract Doc Link 15495532 Disease Relevance 0.36 Pain Relevance 0
The substance ISO-1 of isoxazoline skeleton was the first small molecular inhibitor of MIF, not related to its known substrates.
Negative_regulation (inhibitor) of MIF in skeleton
3) Confidence 0.42 Published 2009 Journal Curr. Med. Chem. Section Abstract Doc Link 19275614 Disease Relevance 0.45 Pain Relevance 0.28
The alpha,beta-unsaturated carbonyl compounds constitute a large novel class of MIF inhibitors.
Negative_regulation (inhibitors) of MIF
4) Confidence 0.42 Published 2009 Journal Curr. Med. Chem. Section Abstract Doc Link 19275614 Disease Relevance 0.26 Pain Relevance 0.18
In this paper, the separate classes of MIF inhibitors are discussed.
Negative_regulation (inhibitors) of MIF
5) Confidence 0.42 Published 2009 Journal Curr. Med. Chem. Section Abstract Doc Link 19275614 Disease Relevance 0.07 Pain Relevance 0.10
An acetylenic compound, the 2-oxo-4-phenyl-3-butynoate is a potent active-site-directed irreversible inhibitor of the phenyl pyruvate tautomerase activity of MIF.
Negative_regulation (inhibitor) of MIF
6) Confidence 0.42 Published 2009 Journal Curr. Med. Chem. Section Abstract Doc Link 19275614 Disease Relevance 0.39 Pain Relevance 0.25
Some oxygen heterocycles, coumarines and chromenes, have also drawn attention as MIF inhibitors.
Negative_regulation (inhibitors) of MIF
7) Confidence 0.42 Published 2009 Journal Curr. Med. Chem. Section Abstract Doc Link 19275614 Disease Relevance 0.32 Pain Relevance 0.19
These findings suggest that antioxidant supplementation was helpful in reducing the elevations in plasma CK activity and MS, with little impact on MIF and ROM loss.
Negative_regulation (loss) of MIF in plasma associated with myalgia
8) Confidence 0.42 Published 2004 Journal Int J Sport Nutr Exerc Metab Section Abstract Doc Link 15467097 Disease Relevance 0.43 Pain Relevance 0
Tyr-MIF-1 is a representative of the MIF's family of endogenous peptides.
Negative_regulation (representative) of MIF
9) Confidence 0.41 Published 1998 Journal Arch. Physiol. Biochem. Section Abstract Doc Link 10441059 Disease Relevance 0.34 Pain Relevance 0.19
These results demonstrate sex differences in the younger men and women and a strong pain-induced decrease of MIF availability.
Negative_regulation (decrease) of MIF associated with pain
10) Confidence 0.38 Published 2005 Journal Pain Section Abstract Doc Link 15836977 Disease Relevance 0.90 Pain Relevance 1.36
An acetylenic compound, the 2-oxo-4-phenyl-3-butynoate is a potent active-site-directed irreversible inhibitor of the phenyl pyruvate tautomerase activity of MIF.
Negative_regulation (inhibitor) of tautomerase
11) Confidence 0.37 Published 2009 Journal Curr. Med. Chem. Section Abstract Doc Link 19275614 Disease Relevance 0.39 Pain Relevance 0.25
On the other hand, aspirin and NS398 significantly decreased MIF protein and mRNA expression, and completely blocked bile acid-induced MIF synthesis in the presence or absence of prostaglandin E(2).
Negative_regulation (decreased) of MIF protein in bile associated with aspirin and bile
12) Confidence 0.37 Published 2005 Journal Carcinogenesis Section Abstract Doc Link 15358635 Disease Relevance 0.89 Pain Relevance 0.43
There is no report of malignancy arising from the retained müllerian structures, and the absence of MIF does not appear to increase the relative risk of testicular malignancy.
Negative_regulation (absence) of MIF associated with malignant neoplastic disease
13) Confidence 0.36 Published 2008 Journal Cases J Section Body Doc Link PMC2580765 Disease Relevance 0.80 Pain Relevance 0.03
In the present study, we have demonstrated that KBG treatment significantly suppressed the protein and mRNA levels of MIF, IL-6, IL-8, and TNF-?
Negative_regulation (suppressed) of MIF
14) Confidence 0.24 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3021874 Disease Relevance 0.56 Pain Relevance 0.14
A literature exists on these effects being minimised by blocking MIF, which reduces the feedback inhibition of TNF production by glucocorticoids [225,226].
Negative_regulation (blocking) of MIF
15) Confidence 0.19 Published 2006 Journal Malar J Section Body Doc Link PMC1629020 Disease Relevance 0.95 Pain Relevance 0.27
At the same time, MIF inhibition was shown to correlate with reduced viral load, inflammation and damage in the brain of WNV infected mice [116], depicting the complexity of phenomena involving the innate immunity regulation.
Negative_regulation (inhibition) of MIF in brain associated with inflammation
16) Confidence 0.09 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2878977 Disease Relevance 0.55 Pain Relevance 0.16
Enzymatic analysis indicates that these compounds are noncompetitive inhibitors of the p-hydroxyphenylpyruvate (HPP) tautomerase activity of MIF and an allosteric binding site of AV411 and AV1013 is detected by NMR.
Negative_regulation (inhibitors) of MIF
17) Confidence 0.08 Published 2010 Journal Proc. Natl. Acad. Sci. U.S.A. Section Abstract Doc Link 20534506 Disease Relevance 0.40 Pain Relevance 0.22
Inhibition of tautomerization activity of MIF (macrophage migration inhibitory factor), which is shown to be released from ovarian cancer, and which is necessary for proper ovulation; IV.
Negative_regulation (Inhibition) of MIF in macrophage associated with ovarian cancer
18) Confidence 0.08 Published 2004 Journal Neoplasma Section Abstract Doc Link 15254653 Disease Relevance 0.90 Pain Relevance 0.80

General Comments

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