INT83446

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Context Info
Confidence 0.00
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.17
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CD40LG, CCL2) extracellular region (CD40LG, CCL2) aging (CCL2)
cytoplasm (CCL2) signal transduction (CCL2) cell adhesion (CCL2)
Anatomy Link Frequency
Platelets 2
CD40LG (Homo sapiens)
CCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 1 50.00 Quite Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Atherosclerosis 1 56.84 Quite High
Rupture 1 56.36 Quite High
Acute Coronary Syndrome 2 55.24 Quite High
Cv General 3 Under Development 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our main findings follow. (1) Patients with unstable angina had significantly raised serum levels of sCD40L when compared with patients with stable angina and controls. (2) Platelets could release large amounts of sCD40L when stimulated ex vivo with the thrombin receptor-agonist peptide SFLLRN in both patients and controls. (3) Platelets in patients with unstable angina were characterized ex vivo by decreased intracellular levels and decreased SFLLRN-stimulated release of sCD40L, which may possibly represent a higher percentage of degranulated platelets in these patients. (4) T cells in patients with unstable angina had enhanced surface expression of CD40L and increased release of sCD40L on anti-CD3/anti-CD28 stimulation in vitro when compared with patients with stable angina and controls. (5) Recombinant CD40L and serum from patients with unstable angina who had high sCD40L levels induced enhanced release of monocyte chemoattractant peptide-1 from mononuclear cells, a CC-chemokine involved in the pathogenesis of atherosclerosis.
CD40L Positive_regulation (induced) of Localization (release) of chemoattractant peptide-1 in Platelets
1) Confidence 0.00 Published 1999 Journal Circulation Section Body Doc Link 10441098 Disease Relevance 0.17 Pain Relevance 0

General Comments

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