INT83450

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 28
Total Number 30
Disease Relevance 22.14
Pain Relevance 9.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL2) extracellular space (CCL2) aging (CCL2)
extracellular region (CCL2) cell adhesion (CCL2) cytoskeleton organization (CCL2)
Anatomy Link Frequency
monocyte 13
endothelial cells 8
microglia 6
macrophages 4
THP-1 4
CCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 144 100.00 Very High Very High Very High
chemokine 138 100.00 Very High Very High Very High
ischemia 23 100.00 Very High Very High Very High
Morphine 58 99.98 Very High Very High Very High
cytokine 248 99.76 Very High Very High Very High
dexamethasone 51 99.70 Very High Very High Very High
lidocaine 8 99.54 Very High Very High Very High
opiate 21 98.16 Very High Very High Very High
Inflammation 457 96.60 Very High Very High Very High
Inflammatory mediators 21 95.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 31 100.00 Very High Very High Very High
Lymphatic System Cancer 104 99.96 Very High Very High Very High
Viral Meningitis 5 99.60 Very High Very High Very High
Cancer 275 99.54 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 186 99.44 Very High Very High Very High
Cirrhosis 154 98.88 Very High Very High Very High
Hypoxia 8 98.76 Very High Very High Very High
Infection 50 98.52 Very High Very High Very High
Sepsis 15 96.84 Very High Very High Very High
INFLAMMATION 529 96.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we examined the effect of lidocaine on lipopolysaccharide-stimulated MCP-1 secretion and MCP-1 induced chemotaxis in a human monocytic cell line, THP-1.
Positive_regulation (stimulated) of Localization (secretion) of MCP-1 in THP-1 associated with lidocaine
1) Confidence 0.70 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 14570645 Disease Relevance 0.39 Pain Relevance 0.67
H-89, an inhibitor of PKA, was able to inhibit the decrease in eotaxin and MCP-1 protein release induced by forskolin.
Positive_regulation (induced) of Localization (release) of MCP-1
2) Confidence 0.63 Published 2003 Journal Eur. Respir. J. Section Abstract Doc Link 12952251 Disease Relevance 0.17 Pain Relevance 0.24
Other investigators have shown that the combination of HIV-1 Tat protein and morphine increased the release of CCL2 from astrocytes [25] and subsequently promoted the chemotaxis of microglia [20].
Positive_regulation (increased) of Localization (release) of CCL2 in microglia associated with acquired immune deficiency syndrome or hiv infection and morphine
3) Confidence 0.61 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1712222 Disease Relevance 0.10 Pain Relevance 1.13
Our findings suggest that opiates may increase the vulnerability of the CNS to viral entry (via recruitment of monocytes/macrophages) and ensuing HIV encephalitis by synergistically increasing MCP-1 and RANTES release by astrocytes.
Positive_regulation (increasing) of Localization (release) of MCP-1 in astrocytes associated with acquired immune deficiency syndrome or hiv infection, opiate and viral meningitis
4) Confidence 0.48 Published 2005 Journal Glia Section Abstract Doc Link 15630704 Disease Relevance 0.54 Pain Relevance 1.02
Forskolin, a direct stimulator of adenylyl cyclase, decreased the interleukin (IL)-1beta-induced eotaxin and MCP-1 release by 73+/-8 and 65+/-6%, respectively. 8Bromo-cAMP, a cAMP analogue, similarly decreased the chemokine production by 58+/-9 and 63+/-8% for eotaxin and MCP-1, respectively.
Positive_regulation (induced) of Localization (release) of MCP-1 associated with chemokine
5) Confidence 0.43 Published 2003 Journal Eur. Respir. J. Section Abstract Doc Link 12952251 Disease Relevance 0.23 Pain Relevance 0.21
The immunosuppressant cyclosporin A (50 microM) partially reduced the ischemia-stimulated IL-8 and MCP-1 secretion by HCEC.
Spec (partially) Positive_regulation (ischemia-stimulated) of Localization (secretion) of MCP-1 in HCEC associated with ischemia
6) Confidence 0.41 Published 2000 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 11450070 Disease Relevance 1.14 Pain Relevance 0.60
In this study, we show that human cere-bromicrovascular endothelial cells (HCEC) subjected to a 4 h in vitro ischemia (hypoxia + glucose deprivation) followed by a 4-24 h recovery express elevated levels of ICAM-1, IL-8, and MCP-1 mRNAs (semi-quantitative RT-PCR) and secrete increased amounts of the immunoreactive chemokines IL-8 and MCP-1 (ELISA).
Positive_regulation (elevated) of Localization (levels) of MCP-1 in HCEC associated with chemokine, hypoxia and ischemia
7) Confidence 0.41 Published 2000 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 11450070 Disease Relevance 0.97 Pain Relevance 0.43
This study investigates chemokine secretion induced by co-culture of hRPE cells and monocytes and illustrates the roles of p38 kinase, ERK, JNK/SAPK and NF-kappaB-inducing kinase signaling pathways for hRPE IL-8 and MCP-1 secretion induced in hRPE by co-culture with monocytes.
Positive_regulation (induced) of Localization (secretion) of MCP-1 in monocytes associated with chemokine
8) Confidence 0.37 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.09 Pain Relevance 0.12
Synergistic increases in intracellular Ca2+, and the release of MCP-1, RANTES, and IL-6 by astrocytes treated with opiates and HIV-1 Tat.
Positive_regulation (increases) of Localization (release) of MCP-1 in astrocytes associated with acquired immune deficiency syndrome or hiv infection, opiate and cytokine
9) Confidence 0.34 Published 2005 Journal Glia Section Title Doc Link 15630704 Disease Relevance 0.87 Pain Relevance 0.72
These included increased transcription of chemokines localized to chromosome 17q11.2 (CCL13, CCL2, CCL8, and CCL11) that favor eosinophil and monocyte chemotaxis and chemokines (CCL18, CCL22, and CXCL13) that alternatively-activated monocyte-derived cells have been shown to produce.
Positive_regulation (increased) of Localization (localized) of CCL2 in monocyte associated with chemokine
10) Confidence 0.32 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2897889 Disease Relevance 1.84 Pain Relevance 0.17
Furthermore, IL-1beta and tumor necrosis factor-alpha alone induced significant release of MCP-1, IL-6 and SCF but in combination with IL-4 or IL-13 it induced greater secretion of MCP-1, IL-6 and SCF.
Positive_regulation (induced) of Localization (secretion) of MCP-1
11) Confidence 0.31 Published 2006 Journal J. Urol. Section Body Doc Link 16407046 Disease Relevance 0.11 Pain Relevance 0
Co-culture of hRPE cells with monocytes increased steady-state IL-8 and MCP-1 mRNA and protein secretion.
Positive_regulation (increased) of Localization (secretion) of MCP-1 mRNA in monocytes
12) Confidence 0.27 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.14 Pain Relevance 0.17
Homocysteine induced the expression and secretion of the pro-atherogenic chemokine, monocyte chemoattractant protein-1 (MCP-1), and the cytokine, interleukin-8 (IL-8), in human aortic endothelial cells [7].
Positive_regulation (induced) of Localization (secretion) of MCP-1 in endothelial cells associated with chemokine and cytokine
13) Confidence 0.26 Published 2008 Journal Archives of Drug Information Section Body Doc Link PMC2817441 Disease Relevance 0.60 Pain Relevance 0.16
AM630 did not influence IL-6 levels; however, there was a trend toward increased MCP-1 secretion (Figure 3C&D).
Positive_regulation (increased) of Localization (secretion) of MCP-1
14) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.62 Pain Relevance 0.28
In vitro, leukocytic microparticles trigger the release of IL-6 and MCP-1 from endothelial cells [22,23].
Positive_regulation (trigger) of Localization (release) of MCP-1 in endothelial cells
15) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174949 Disease Relevance 0.20 Pain Relevance 0.23
In comparison with plasma, levels of MCP-1 (P = 0.008), IL-6 (P = 0.002), IL-8 (P = 0.002) and VEGF (P = 0.002) were elevated in synovial fluid, those of RANTES and ICAM-1 were decreased (P = 0.001 and P = 0.006, respectively), and GM-CSF concentrations were similar (P = 0.125).
Positive_regulation (elevated) of Localization (levels) of MCP-1 in synovial fluid
16) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174949 Disease Relevance 0.18 Pain Relevance 0.09
These experiments demonstrated that IL-6 and MCP-1 secretion were significantly reduced by WIN (p?
Positive_regulation (by) of Localization (secretion) of MCP-1
17) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.58 Pain Relevance 0.21
ATP stimulates release of IL-6, IL-8, monocyte chemoattractant protein-1, growth-regulated oncogene ?
Positive_regulation (stimulates) of Localization (release) of monocyte chemoattractant protein-1 in monocyte
18) Confidence 0.16 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 1.09 Pain Relevance 0.15
Both BOL-303242-X and DEX inhibited LPS-induced IL-6, IL-12p40, and MCP-1 release in a dose-dependent manner, and a statistically significant inhibitory effect on IL-6, IL-12p40, and MCP-1 release was observed at 1 nM (Figure 5).
Positive_regulation (induced) of Localization (release) of MCP-1 associated with dexamethasone
19) Confidence 0.14 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 0.22 Pain Relevance 0.64
In experiments where B. burgdorferi was co-cultured in vitro with primary microglia, we observed robust expression and release of IL-6 and IL-8, CCL2 (MCP-1), CCL3 (MIP-1?)
Positive_regulation (observed) of Localization (release) of CCL2 in microglia
20) Confidence 0.13 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2771360 Disease Relevance 1.08 Pain Relevance 0.16

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