INT83451

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Context Info
Confidence 0.60
First Reported 1999
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 26
Total Number 34
Disease Relevance 22.81
Pain Relevance 6.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CD40LG) extracellular region (CD40LG) plasma membrane (CD40LG)
Anatomy Link Frequency
platelet 10
mature B cells 3
plasma cells 2
bone marrow 2
bowel 2
CD40LG (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 53 100.00 Very High Very High Very High
intrathecal 28 100.00 Very High Very High Very High
rheumatoid arthritis 162 99.90 Very High Very High Very High
Multiple sclerosis 134 99.78 Very High Very High Very High
tolerance 9 99.62 Very High Very High Very High
Arthritis 332 98.88 Very High Very High Very High
cytokine 233 98.52 Very High Very High Very High
Adalimumab 40 97.72 Very High Very High Very High
Inflammation 242 97.52 Very High Very High Very High
Inflammatory marker 12 92.04 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 162 99.90 Very High Very High Very High
Demyelinating Disease 145 99.78 Very High Very High Very High
Chronic Fatigue Syndrome 152 99.52 Very High Very High Very High
Disease 273 99.22 Very High Very High Very High
Viremia 21 99.16 Very High Very High Very High
Juvenile Chronic Polyarthritis 292 98.88 Very High Very High Very High
Infection 364 98.84 Very High Very High Very High
Epstein-barr Virus 58 98.56 Very High Very High Very High
Systemic Lupus Erythematosus 57 98.36 Very High Very High Very High
Autoimmune Disease 66 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After stimulation in vitro, peripheral blood T-cells from patients with RA had increased and longer expression of CD154 compared to T-cells from controls [16].
Positive_regulation (increased) of Gene_expression (expression) of CD154 in blood associated with rheumatoid arthritis
1) Confidence 0.60 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 1.68 Pain Relevance 0.74
Our main findings follow. (1) Patients with unstable angina had significantly raised serum levels of sCD40L when compared with patients with stable angina and controls. (2) Platelets could release large amounts of sCD40L when stimulated ex vivo with the thrombin receptor-agonist peptide SFLLRN in both patients and controls. (3) Platelets in patients with unstable angina were characterized ex vivo by decreased intracellular levels and decreased SFLLRN-stimulated release of sCD40L, which may possibly represent a higher percentage of degranulated platelets in these patients. (4) T cells in patients with unstable angina had enhanced surface expression of CD40L and increased release of sCD40L on anti-CD3/anti-CD28 stimulation in vitro when compared with patients with stable angina and controls. (5) Recombinant CD40L and serum from patients with unstable angina who had high sCD40L levels induced enhanced release of monocyte chemoattractant peptide-1 from mononuclear cells, a CC-chemokine involved in the pathogenesis of atherosclerosis.
Positive_regulation (enhanced) of Gene_expression (expression) of CD40L in monocyte
2) Confidence 0.49 Published 1999 Journal Circulation Section Body Doc Link 10441098 Disease Relevance 0.19 Pain Relevance 0
The diagnosis of WM was established after cytomorphologic and immunohistochemical analysis of the patient's bone marrow revealed the presence of a lymphoid/lymphoplasmacytoid-like bone marrow infiltrate along with an elevated serum IgM level.
Spec (like) Positive_regulation (elevated) of Gene_expression (level) of IgM in bone marrow associated with macroglobulinemia
3) Confidence 0.47 Published 2006 Journal Am. J. Hematol. Section Abstract Doc Link 16888782 Disease Relevance 1.14 Pain Relevance 0.28
There were two to three times mean-fold increases in anti-J5dLPS IgG (range: 1.9-5.1) and IgM (range: 1.2-9.2) levels in subjects receiving the 10 and 25 microg doses.
Positive_regulation (increases) of Gene_expression (levels) of IgM
4) Confidence 0.44 Published 2003 Journal Vaccine Section Abstract Doc Link 14575770 Disease Relevance 0.24 Pain Relevance 0.18
In our study, it is possible that UFP exposure caused both an increase in platelet expression of CD40L and a more rapid clearance of CD40L from the plasma.
Positive_regulation (increase) of Gene_expression (expression) of CD40L in platelet
5) Confidence 0.39 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0.23 Pain Relevance 0
An increase in platelet expression of CD40L was detected 3.5 hr after UFP exposure, yet soluble CD40L levels decreased, reaching a nadir 21 hr after exposure.
Positive_regulation (increase) of Gene_expression (expression) of CD40L in platelet
6) Confidence 0.39 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0.55 Pain Relevance 0
Of note, sCD154 levels were most increased in children with RF+ polyarticular and systemic JIA as well as ERA than in the other types of disease.
Positive_regulation (increased) of Gene_expression (levels) of sCD154 associated with disease and arthritis
7) Confidence 0.37 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 1.00 Pain Relevance 0.58
Of special interest to us were the increased serum levels of sCD154 in children with different JIA subtypes.
Positive_regulation (increased) of Gene_expression (levels) of sCD154 associated with arthritis
8) Confidence 0.35 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 1.49 Pain Relevance 0.72
Increased levels of sCD154 have been demonstrated in patients with SLE, [18], RA, [19], inflammatory bowel diseases (IBD) [20], systemic sclerosis [21,22] and Sjogren's syndrome [23].
Positive_regulation (Increased) of Gene_expression (levels) of sCD154 in bowel associated with inflammatory bowel disease, inflammation, syndrome, rheumatoid arthritis, systemic sclerosis and systemic lupus erythematosus
9) Confidence 0.35 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 1.52 Pain Relevance 0.59
It remains unknown now why, in our MS subjects, exclusively IgM APLA was found; however, we hypothesize that since the subjects in this study were all newly diagnosed they had not yet class-switched to IgG.
Positive_regulation (exclusively) of Gene_expression (found) of IgM associated with multiple sclerosis
10) Confidence 0.33 Published 2007 Journal BMC Neurol Section Body Doc Link PMC2219992 Disease Relevance 0.77 Pain Relevance 0.31
For platelet expression of CD40L, we observed a mean 13% increase [44 vs. 40 MEPE (molecules of equivalent phycoerythrin) units] 3.5 hr after UFP exposure.
Positive_regulation (increase) of Gene_expression (expression) of CD40L in platelet
11) Confidence 0.28 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0.48 Pain Relevance 0.16
Mean CD40L expression increased significantly 3.5 hr after exposure to UFP compared with air (Figure 1A), with a significant UFP–time interaction, indicating the UFP effect on CD40L expression differed over time.
Positive_regulation (increased) of Gene_expression (expression) of CD40L
12) Confidence 0.28 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0.06 Pain Relevance 0
Thus, the observed increases in vWF, platelet expression of CD40L, and platelet-leukocyte conjugates are consistent with platelet activation in response to UFP exposure.
Positive_regulation (increases) of Gene_expression (expression) of CD40L in leukocyte
13) Confidence 0.28 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0.58 Pain Relevance 0
The loss of tolerance model due to CD40–CD40L activation signals
Positive_regulation (activation) of Gene_expression (signals) of CD40L associated with tolerance
14) Confidence 0.28 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661661 Disease Relevance 0.84 Pain Relevance 0.44
CD40L expression 3.5 hr after UFP was increased from baseline levels in 9 of the 13 subjects with complete data [see Supplemental Material, Figure 1 (doi:10.1289/ehp.1002237)].
Positive_regulation (increased) of Gene_expression (expression) of CD40L
15) Confidence 0.26 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0.05 Pain Relevance 0
Compared with air, particle exposure increased platelet expression of CD40 ligand (CD40L) and the number of platelet-leukocyte conjugates 3.5 hr after exposure.
Positive_regulation (increased) of Gene_expression (expression) of CD40L in platelet
16) Confidence 0.26 Published 2010 Journal Environ Health Perspect Section Abstract Doc Link PMC3002188 Disease Relevance 0.42 Pain Relevance 0.05
Platelet expression of CD40L and the number of platelet-leukocyte conjugates increased 3.5 hr after exposure.
Positive_regulation (increased) of Gene_expression (expression) of CD40L in Platelet
17) Confidence 0.26 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0.32 Pain Relevance 0
IgG, IgM and IgA levels are elevated universally in the human host upon EBV infection due to the general activation of B-cells [2].
Positive_regulation (elevated) of Gene_expression (IgG) of IgM in B-cells associated with epstein-barr virus and infection
18) Confidence 0.20 Published 2005 Journal Virol J Section Body Doc Link PMC1243244 Disease Relevance 1.08 Pain Relevance 0
Tests for IgM RF and anti-CCP autoantibodies were performed at baseline and after 6 and 12 months of adalimumab treatment.
Positive_regulation (Tests) of Gene_expression (autoantibodies) of IgM associated with adalimumab
19) Confidence 0.16 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.44 Pain Relevance 0.25
In conclusion the results of our study reveal an accumulation of mature B cells and plasma blasts in the CSF of patients with a CIS and RRMS, which is associated with an increased intrathecal CSF cell count and MMP-9, CxCL-13, IgG and IgM synthesis.
Positive_regulation (increased) of Gene_expression (synthesis) of IgM in mature B cells associated with metalloproteinase, disease and intrathecal
20) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2438478 Disease Relevance 0.67 Pain Relevance 0.60

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