INT83461

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Context Info
Confidence 0.47
First Reported 1999
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 9.70
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (RET) signal transduction (RET) plasma membrane (RET)
Anatomy Link Frequency
glial cell 1
germ line 1
thyroid gland 1
RET (Homo sapiens)
Pain Link Frequency Relevance Heat
Glial derived neurotrophic factor 2 99.08 Very High Very High Very High
lidocaine 5 97.76 Very High Very High Very High
headache 3 97.20 Very High Very High Very High
imagery 9 96.16 Very High Very High Very High
peptic ulcer disease 2 81.60 Quite High
Dopamine 3 79.28 Quite High
backache 1 68.76 Quite High
Catecholamine 8 31.24 Quite Low
palliative 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 294 100.00 Very High Very High Very High
Multiple Endocrine Neoplasia Type 2a 138 100.00 Very High Very High Very High
Multiple Endocrine Neoplasia Type 2b 43 100.00 Very High Very High Very High
Multiple Endocrine Neoplasia 11 100.00 Very High Very High Very High
Pheochromocytoma 55 99.60 Very High Very High Very High
Carcinoma 23 99.56 Very High Very High Very High
Hypercalcemia 30 99.28 Very High Very High Very High
Metastasis 24 98.84 Very High Very High Very High
Pancreatic Cancer 8 98.36 Very High Very High Very High
Headache 3 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rarely, MEN2A is recognized during the search for PHT associated conditions.
MEN2A Binding (recognized) of associated with multiple endocrine neoplasia type 2a and hypercalcemia
1) Confidence 0.47 Published 2008 Journal Arq Bras Endocrinol Metabol Section Abstract Doc Link 19169490 Disease Relevance 2.35 Pain Relevance 0.08
A subsequent study in eight patients found that neither haemodynamic nor hormonal changes associated with PTC in the placebo group were altered by administration of lidocaine 200 mg i.m. before PTC.
PTC Neg (neither) Binding (associated) of associated with lidocaine
2) Confidence 0.35 Published 1999 Journal Br J Anaesth Section Abstract Doc Link 10536544 Disease Relevance 0 Pain Relevance 0.46
Nearly 100% of MEN2A are associated with germ line mutation of the RET proto-oncogene (RET), and DNA-based RET genotype analysis is now considered essential for earlier diagnosis.
MEN2A Binding (associated) of in germ line associated with multiple endocrine neoplasia type 2a
3) Confidence 0.35 Published 2008 Journal Arq Bras Endocrinol Metabol Section Abstract Doc Link 19169490 Disease Relevance 1.98 Pain Relevance 0.06
The relationship between overexpression of glial cell-derived neurotrophic factor and its RET receptor with progression and prognosis of human pancreatic cancer.
RET Binding (receptor) of in glial cell associated with pancreatic cancer
4) Confidence 0.35 Published 2008 Journal J. Int. Med. Res. Section Title Doc Link 18652760 Disease Relevance 0.83 Pain Relevance 0.07
[A case of multiple endocrine neoplasia type 2A (MEN2A) with a mutation in the RET gene].
MEN2A Binding (case) of associated with multiple endocrine neoplasia type 2a and multiple endocrine neoplasia
5) Confidence 0.32 Published 1999 Journal Hinyokika Kiyo Section Title Doc Link 10442282 Disease Relevance 0.78 Pain Relevance 0.15
The RET protein is a subunit of a multimolecular complex that binds growth factors of the glial derived neurotrophic factor (GDNF) family.
RET Binding (binds) of associated with glial derived neurotrophic factor
6) Confidence 0.28 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1654141 Disease Relevance 0.97 Pain Relevance 0.05
In contrast, most of MEN2B cases are associated with mutations in the intracellular tyrosine kinase receptor domains of RET: more than 95% of MEN2B patients bear the M918T mutation at exon 16, while about 5% of MEN2B patients harbor the A883F substitution at exon 15 [20,21].
MEN2B Binding (associated) of associated with multiple endocrine neoplasia type 2b
7) Confidence 0.28 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1654141 Disease Relevance 1.37 Pain Relevance 0
Thyroidectomy is the preferred initial management of PTC, FC, MTC, HCC, and isolated metastases to the thyroid gland (Udelsman and Chen 1999; Chen et al 1999; Cheema et al 2006; Greenblatt et al 2007).
PTC Binding (management) of in thyroid gland associated with thyroid neoplasm, carcinoma and metastasis
8) Confidence 0.27 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 1.42 Pain Relevance 0

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