INT8347

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1982
Last Reported 2010
Negated 3
Speculated 2
Reported most in Abstract
Documents 181
Total Number 183
Disease Relevance 104.59
Pain Relevance 65.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SST) extracellular region (SST) cell-cell signaling (SST)
Anatomy Link Frequency
pituitary 9
plasma 8
endocrine cells 4
neurons 4
corticotroph 4
SST (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 3026 100.00 Very High Very High Very High
Dopamine 816 100.00 Very High Very High Very High
Neuropeptide 140 100.00 Very High Very High Very High
Serotonin 110 100.00 Very High Very High Very High
antagonist 97 100.00 Very High Very High Very High
Enkephalin 80 100.00 Very High Very High Very High
substance P 69 100.00 Very High Very High Very High
Cholecystokinin 44 100.00 Very High Very High Very High
Dynorphin 11 100.00 Very High Very High Very High
Calcitonin gene-related peptide 11 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 3587 100.00 Very High Very High Very High
Adenoma 214 100.00 Very High Very High Very High
Malignant Tumors Of Salivary Glands 4 100.00 Very High Very High Very High
Carcinoid 898 99.98 Very High Very High Very High
Prolactinoma 758 99.98 Very High Very High Very High
Reprotox - General 1 141 99.98 Very High Very High Very High
Pancreatic Cancer 105 99.96 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 260 99.92 Very High Very High Very High
Metastasis 491 99.88 Very High Very High Very High
Acth-secreting Pituitary Adenoma 112 99.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The regulation of receptor expression as well as receptor internalization can give us insight into the effect of exogenous somatostatin on schistosomiasis-mediated intestinal pathology, as well as its modulation by intrinsically produced somatostatin levels.
Gene_expression (produced) of somatostatin associated with somatostatin and schistosomiasis
1) Confidence 0.78 Published 2001 Journal Trop. Med. Int. Health Section Abstract Doc Link 11737838 Disease Relevance 0.69 Pain Relevance 0.37
The comparatively low estimated radiation doses to normal organs support the initiation of clinical phase I trials with [90Y]DOTA-DPhe1-Tyr3-octreotide in patients with somatostatin receptor-expressing tumours.
Gene_expression (expressing) of somatostatin associated with cancer and somatostatin
2) Confidence 0.78 Published 1999 Journal Eur J Nucl Med Section Abstract Doc Link 10199941 Disease Relevance 0.10 Pain Relevance 0.16
Uptake kinetics of the somatostatin receptor ligand [86Y]DOTA-DPhe1- Tyr3-octreotide ([86Y]SMT487) using positron emission tomography in non-human primates and calculation of radiation doses of the 90Y-labelled analogue.

[90Y]DOTA-DPhe1-Tyr3-octreotide ([90Y]-SMT487) has been suggested as a promising radiotherapeutic agent for somatostatin receptor-expressing tumours.

Gene_expression (expressing) of somatostatin associated with anesthesia, cancer, positron emission tomography and somatostatin
3) Confidence 0.78 Published 1999 Journal Eur J Nucl Med Section Title Doc Link 10199941 Disease Relevance 0.10 Pain Relevance 0.36
Submucous neurons expressed SST2 receptors.
Gene_expression (expressed) of SST2 in neurons
4) Confidence 0.76 Published 2010 Journal Gastroenterology Section Body Doc Link 19786030 Disease Relevance 0 Pain Relevance 0
We report here a case of malignant pancreatic endocrine tumor producing somatostatin presented as relapsing cholangitis who was treated with Whipple pancreatoduodenectomy.
Gene_expression (producing) of somatostatin associated with cholangitis, malignant neoplastic disease, cancer and somatostatin
5) Confidence 0.75 Published 2005 Journal Pancreatology Section Abstract Doc Link 15849491 Disease Relevance 1.66 Pain Relevance 0.26
Somatostatinoma is a rare somatostatin-producing endocrine tumor, probably malignant.
Gene_expression (producing) of somatostatin associated with malignant neoplastic disease, cancer, somatostatin and somatostatinoma
6) Confidence 0.75 Published 2009 Journal Journal of gastrointestinal and liver diseases : JGLD Section Abstract Doc Link 19565056 Disease Relevance 0.92 Pain Relevance 0.14
Somatostatin releasing inhibitory factor, vasopressin, and oxytocin were detected in the hypothalamus from weeks 12 to 14 onwards, and monoamine oxidase, succinic dehydrogenase, parvalbumin, calbindin D28K, and vasoactive intestinal peptide were found in the visual cortex at midgestation.
Gene_expression (detected) of Somatostatin in cortex associated with somatostatin and monoamine
7) Confidence 0.75 Published 1999 Journal Microsc. Res. Tech. Section Abstract Doc Link 10402266 Disease Relevance 0 Pain Relevance 0.83
Alongside the alpha cell in the islets of Langerhans is the D-cell, which produces somatostatin and may well act physiologically as a paracrine inhibitor of glucagon release.
Gene_expression (produces) of somatostatin in alpha cell associated with somatostatin
8) Confidence 0.75 Published 1987 Journal Am. J. Med. Section Abstract Doc Link 2884877 Disease Relevance 1.35 Pain Relevance 0.16
Immunoperoxidase staining for gastrin-producing G cells, somatostatin-producing D cells and serotonin-producing EC cells was carried out on fundic, antral and duodenal biopsies, and was quantified using a Zeiss MOP Videoplan using the peroxidase-antiperoxidase technique of Sternberger.
Gene_expression (producing) of somatostatin in D cells associated with somatostatin and serotonin
9) Confidence 0.75 Published 1996 Journal Can. J. Gastroenterol. Section Abstract Doc Link 9193776 Disease Relevance 0.48 Pain Relevance 0.31
Since NET usually express somatostatin receptors, scanning with radiolabelled somatostatin analogue (octreotide) is often helpful.
Gene_expression (express) of somatostatin associated with neuroendocrine cancer and somatostatin
10) Confidence 0.75 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1971059 Disease Relevance 1.92 Pain Relevance 0.28
Several hypotheses can be put forward: a cumulative effect of SSTa concentration over time, an increase in hormonal efficacy of the treatment as reported after the reduction in adenoma volume by surgical debulking,26,27 although there was no significant correlation between hormonal control and the change in adenoma volume, or a change in the expression of the SST receptor subtypes on the adenoma cells.
Gene_expression (expression) of SST associated with adenoma
11) Confidence 0.75 Published 2007 Journal Clinical Endocrinology Section Body Doc Link PMC1974833 Disease Relevance 0.38 Pain Relevance 0.20
Neuropeptide expression is plastic; during development, neurons that switch from a noradrenergic to a cholinergic phenotype increase expression of vasoactive intestinal polypeptide, somatostatin, and substance P.
Gene_expression (expression) of somatostatin in neurons associated with somatostatin, neuropeptide and substance p
12) Confidence 0.75 Published 1994 Journal Ann. Neurol. Section Abstract Doc Link 8024263 Disease Relevance 0.23 Pain Relevance 0.78
GH producing cells express the somatostatin receptor.
Gene_expression (express) of somatostatin associated with somatostatin
13) Confidence 0.75 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837063 Disease Relevance 2.09 Pain Relevance 0.43
First, Ptf1a appears to be a master regulator, as indicated by a requirement of Ptf1a for the expression of glycinergic marker GlyT2 and a set of peptides, including neuropeptide Y (NPY), nociceptin/orphanin FQ (N/OFQ), somatostatin (SOM), enkephalin (ENK), dynorphin (DYN) and galanin (GAL).
Gene_expression (expression) of somatostatin associated with dynorphin, orphanin, somatostatin, neuropeptide and enkephalin
14) Confidence 0.75 Published 2008 Journal Dev. Biol. Section Abstract Doc Link 18634777 Disease Relevance 0 Pain Relevance 0.94
Imaging techniques revealed a tumor of the pancreas involving the spleen with metastases of the liver, expressing somatostatin receptors.
Gene_expression (expressing) of somatostatin in liver associated with cancer, somatostatin, imagery and metastasis
15) Confidence 0.75 Published 2008 Journal Internist (Berl) Section Abstract Doc Link 18324381 Disease Relevance 0.85 Pain Relevance 0.18
Increased concentrations of somatostatin, produced by pancreatic D cells or by intestinal mucosa, inihibit secretion of a number of GIT hormones, endocrine and exocrine pancreatic secretion.
Gene_expression (produced) of somatostatin in pancreatic D cells associated with somatostatin
16) Confidence 0.75 Published 2007 Journal Rozhl Chir Section Abstract Doc Link 18303777 Disease Relevance 1.12 Pain Relevance 0.17
Besides somatostatinoma syndrome, which is characterized by diabetes mellitus, steatorrhea and cholelithiasis, patients with somatostatin-producing endocrine tumors commonly complain of nonspecific symptoms such as vague abdominal pain, weight loss or changes in bowel habits.
Gene_expression (producing) of somatostatin in bowel associated with abdominal pain, steatorrhea, diabetes mellitus, syndrome, somatostatin, gallstones, weight loss, cancer and somatostatinoma
17) Confidence 0.75 Published 2005 Journal Pancreatology Section Abstract Doc Link 15849491 Disease Relevance 1.62 Pain Relevance 0.27
Twenty-four hours after rTSH administration, the patient was submitted to a second [111In-DTPA-D-phe1]octreotide scan, revealing significant orbital uptake, likely related to rapid accumulation of activated lymphocytes with inflammatory cytokines or fibroblasts expressing somatostatin receptors in the orbital tissue or interstitial edema due to the inflammation process.
Gene_expression (expressing) of somatostatin in fibroblasts associated with inflammation, somatostatin, edema and cytokine
18) Confidence 0.75 Published 2005 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 15687327 Disease Relevance 1.00 Pain Relevance 0.28
Somatostatin-producing pancreatic endocrine carcinoma presented as relapsing cholangitis -- a case report.
Gene_expression (producing) of Somatostatin associated with cholangitis, somatostatin and carcinoma
19) Confidence 0.75 Published 2005 Journal Pancreatology Section Title Doc Link 15849491 Disease Relevance 1.53 Pain Relevance 0.26
Somatostatin-producing duodenal carcinoids in patients with von Recklinghausen's neurofibromatosis.
Gene_expression (producing) of Somatostatin associated with carcinoid, somatostatin and neurofibromatosis
20) Confidence 0.75 Published 1990 Journal Cancer Section Title Doc Link 1968779 Disease Relevance 1.37 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox