INT83489

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Context Info
Confidence 0.36
First Reported 1999
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.48
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr5b) signal transducer activity (Htr5b)
Anatomy Link Frequency
dorsal 1
nucleus 1
hippocampus 1
Htr5b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 6 100.00 Very High Very High Very High
monoamine 3 100.00 Very High Very High Very High
Hippocampus 17 99.90 Very High Very High Very High
Dopamine 2 99.56 Very High Very High Very High
Versed 10 99.36 Very High Very High Very High
opiate 1 95.68 Very High Very High Very High
Neuropeptide 1 94.40 High High
agonist 6 92.60 High High
Eae 8 88.96 High High
antagonist 2 82.24 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 6 93.64 High High
Schizophrenia 1 90.52 High High
Pain 2 73.24 Quite High
Psychosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At 96 h after the administration of picrotoxin into the basolateral nucleus, we have observed an increase in the expression of genes associated with 18 different monoamine (ie adrenergic alpha 1, alpha 2 and beta 2, serotonergic 5HT5b and 5HT6, dopamine D4 and muscarinic m1, m2 and m3) and peptide (CCK A and B, angiotensin 1A, mu and kappa opiate, FSH, TSH, LH, GNRH, and neuropeptide Y) G-protein coupled receptors (GPCRs).
5HT5b Binding (associated) of in nucleus associated with dopamine, neuropeptide, opiate and monoamine
1) Confidence 0.36 Published 2004 Journal Mol. Psychiatry Section Abstract Doc Link 15170462 Disease Relevance 0.09 Pain Relevance 0.35
The role of the hippocampus and 5-HT/GABA interaction in the central effects of benzodiazepine receptor ligands.
5-HT Binding (interaction) of in hippocampus associated with gaba, versed and hippocampus
2) Confidence 0.26 Published 1999 Journal J Neural Transm Section Title Doc Link 10443544 Disease Relevance 0.13 Pain Relevance 0.83
Moreover, the obtained results indicate that the dorsal HP is one of the central sites important for GABA/5-HT interaction that modulates rat emotional behavior.
5-HT Binding (interaction) of in dorsal associated with gaba and hippocampus
3) Confidence 0.26 Published 1999 Journal J Neural Transm Section Abstract Doc Link 10443544 Disease Relevance 0.25 Pain Relevance 0.70

General Comments

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