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Context Info
Confidence 0.47
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.84
Pain Relevance 4.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr5b) signal transducer activity (Htr5b)
Anatomy Link Frequency
neuron 1
frontal cortex 1
Htr5b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Analgesic 17 99.96 Very High Very High Very High
Spinal cord 6 99.80 Very High Very High Very High
Locus ceruleus 13 99.54 Very High Very High Very High
Periaqueductal grey 40 99.14 Very High Very High Very High
Pain threshold 1 99.04 Very High Very High Very High
Serotonin 10 98.12 Very High Very High Very High
Hippocampus 16 98.08 Very High Very High Very High
fluoxetine 14 97.20 Very High Very High Very High
Antinociceptive 15 97.16 Very High Very High Very High
Eae 13 96.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 42 99.24 Very High Very High Very High
Pain 44 99.04 Very High Very High Very High
Anxiety Disorder 3 85.52 High High
Nociception 16 76.92 Quite High
Hyperalgesia 22 55.80 Quite High
Neuropathic Pain 38 5.00 Very Low Very Low Very Low
INFLAMMATION 19 5.00 Very Low Very Low Very Low
Fever 10 5.00 Very Low Very Low Very Low
Inflammatory Pain 8 5.00 Very Low Very Low Very Low
Depression 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vivo microdialysis revealed that a single treatment with YM992 (3, 10, 30 mg/kg i.p.) dose-dependently increased extracellular 5-HT levels in the rat frontal cortex.
Positive_regulation (increased) of extracellular 5-HT in frontal cortex associated with urological neuroanatomy
1) Confidence 0.47 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10781669 Disease Relevance 0.17 Pain Relevance 0.28
Picrotoxin administered to the HP produced a tendency to increase locomotor activity in rats, and significantly attenuated the anti-conflict action of serotonin depletion without changing the pain threshold and spontaneous drinking of the animals. p-CPA induced potent, dose-dependent and selective 5-HT and 5-hydroxyindoleacetic acid decrease in the HP after administering the dose used in the behavioral experiment.
Positive_regulation (induced) of 5-HT in CPA associated with pain threshold, eae, hippocampus and serotonin
2) Confidence 0.34 Published 1999 Journal J Neural Transm Section Abstract Doc Link 10443544 Disease Relevance 0.32 Pain Relevance 1.00
The recruitment of "alternative" pathways, such as PAG-locus coeruleus (LC)-spinal cord might be responsible for AA-5-HT effect since we found evidence that (i) intra-PAG AA-5-HT increased LC neuron firing activities, and (ii) intrathecal phentolamine or ketanserin prevented the analgesic effect of AA-5-HT.
Spec (might) Positive_regulation (responsible) of AA-5-HT in neuron associated with analgesic, locus ceruleus, periaqueductal grey, intrathecal and spinal cord
3) Confidence 0.25 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18616956 Disease Relevance 0.66 Pain Relevance 1.53
Indeed, it is now well established that the latter results from an increased stimulation of 5-HT1A inhibitory autoreceptors, which itself is consecutive to the strong elevation of extracellular 5-HT levels that follows 5-HT reuptake blockade in the somatodendritic area [17]–[18], [20].
Positive_regulation (elevation) of extracellular 5-HT
4) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821932 Disease Relevance 0 Pain Relevance 0.17
Being analgesic, AA-5-HT should have induced an increase in the OFF cell activity.
Positive_regulation (induced) of AA-5-HT associated with analgesic
5) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959024 Disease Relevance 0.68 Pain Relevance 1.59

General Comments

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