INT8351

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Context Info
Confidence 0.57
First Reported 1984
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 10.60
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (LOC360919) extracellular space (LOC360919)
Anatomy Link Frequency
liver 3
bone marrow 1
LOC360919 (Rattus norvegicus)
LOC360919 - Y7R (1)
Pain Link Frequency Relevance Heat
alcohol 2 99.68 Very High Very High Very High
palliative 3 98.56 Very High Very High Very High
Pain 3 96.84 Very High Very High Very High
abdominal pain 5 94.08 High High
Dismenorea 1 91.48 High High
depression 1 84.24 Quite High
cva 1 81.44 Quite High
vincristine 1 57.60 Quite High
anesthesia 2 34.88 Quite Low
fibrosis 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 16 99.92 Very High Very High Very High
Alcohol Addiction 2 99.92 Very High Very High Very High
Congenital Anomalies 1 99.90 Very High Very High Very High
Hepatitis B Virus Infection 1 99.80 Very High Very High Very High
Liver Cancer 10 99.60 Very High Very High Very High
Cv Unclassified Under Development 1 99.24 Very High Very High Very High
Cirrhosis 6 98.88 Very High Very High Very High
Hepatitis 5 98.08 Very High Very High Very High
Hepatocellular Cancer 31 97.76 Very High Very High Very High
Hypesthesia 1 97.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum alpha-fetoprotein levels were found to be elevated in all patients.
Positive_regulation (elevated) of Serum alpha-fetoprotein
1) Confidence 0.57 Published 2004 Journal Acta Chir. Belg. Section Abstract Doc Link 15285545 Disease Relevance 0.98 Pain Relevance 0.09
Ten patients with unresectable primary liver cancer, eight of whom had elevated serum alpha-fetoprotein levels, were treated with intrahepatic fluorodeoxyuridine (FUDR) and mitomycin C administered through an implantable pump.
Positive_regulation (elevated) of serum alpha-fetoprotein in liver associated with liver cancer
2) Confidence 0.56 Published 1992 Journal Cancer Section Abstract Doc Link 1370918 Disease Relevance 0.29 Pain Relevance 0.06
Further evaluation revealed an increased level of serum alpha-fetoprotein (24278 ng/ml), cryptogenic liver cirrhosis and primary hepatocellular carcinoma with protruding T3 vertebra metastasis that resulted in Pancoast's syndrome.
Positive_regulation (increased) of serum alpha-fetoprotein in liver associated with cirrhosis, syndrome, hepatocellular cancer and metastasis
3) Confidence 0.56 Published 2001 Journal Jpn. J. Clin. Oncol. Section Abstract Doc Link 11336324 Disease Relevance 1.17 Pain Relevance 0.18
Serum alpha-fetoprotein was not elevated and Hepatitis B antigen was negative.
Neg (not) Positive_regulation (elevated) of Serum alpha-fetoprotein associated with hepatitis b virus infection
4) Confidence 0.55 Published 2001 Journal Malays J Pathol Section Abstract Doc Link 12166592 Disease Relevance 1.11 Pain Relevance 0.09
Serum alpha-fetoprotein, measured in 6 patients, was significantly elevated in 4 (range: 807-1399 ng/ml), and only moderately elevated in 2 (25 and 171 ng/ml).
Positive_regulation (elevated) of Serum alpha-fetoprotein
5) Confidence 0.55 Published 1991 Journal Am. J. Hematol. Section Abstract Doc Link 1650134 Disease Relevance 2.16 Pain Relevance 0.14
In conclusion, the combination of intrahepatic FUDR and mitomycin C was an effective palliative regimen for unresectable primary liver cancer, even in the presence of elevated serum alpha-fetoprotein levels.
Positive_regulation (elevated) of serum alpha-fetoprotein in liver associated with liver cancer and palliative
6) Confidence 0.40 Published 1992 Journal Cancer Section Abstract Doc Link 1370918 Disease Relevance 0.34 Pain Relevance 0.10
Serum alpha-fetoprotein, measured in 6 patients, was significantly elevated in 4 (range: 807-1399 ng/ml), and only moderately elevated in 2 (25 and 171 ng/ml).
Positive_regulation (elevated) of Serum alpha-fetoprotein
7) Confidence 0.37 Published 1991 Journal Am. J. Hematol. Section Abstract Doc Link 1650134 Disease Relevance 2.21 Pain Relevance 0.14
Elevated serum alpha-fetoprotein in 26 patients improved in 22 (85%).
Positive_regulation (Elevated) of serum alpha-fetoprotein
8) Confidence 0.37 Published 1984 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 6202239 Disease Relevance 1.00 Pain Relevance 0.19
Increased serum alpha-fetoprotein level (3.0 multiple of median) was observed.
Positive_regulation (Increased) of serum alpha-fetoprotein
9) Confidence 0.04 Published 2003 Journal J Nippon Med Sch Section Abstract Doc Link 14578949 Disease Relevance 0.59 Pain Relevance 0.13
Neither bone marrow abnormalities nor elevation of serum alpha-fetoprotein was found.
Neg (Neither) Positive_regulation (elevation) of serum alpha-fetoprotein in bone marrow associated with congenital anomalies
10) Confidence 0.04 Published 2001 Journal Folia Med (Plovdiv) Section Abstract Doc Link 11930835 Disease Relevance 0.74 Pain Relevance 0.12
Based on our PASTA predictions and docking searches (see above), however, the self-adhesive region was identified as the overlapping Tyr-7 to Arg-12 sequence, which likely forms an antiparallel ?
Positive_regulation (overlapping) of Arg (Y7R)
11) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2805716 Disease Relevance 0 Pain Relevance 0

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