INT83525

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Context Info
Confidence 0.57
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Pnmt) cytoplasm (Pnmt)
Anatomy Link Frequency
adrenal medulla 2
Pnmt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 2 99.68 Very High Very High Very High
medulla 2 94.96 High High
Catecholamine 5 94.24 High High
anesthesia 1 10.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adrenal phenylethanolamine N-methyl-transferase (PNMT) mRNA levels were increased 4 h after both the PH and laparotomy and declined within 24 h.
Negative_regulation (declined) of Transcription (levels) of PNMT
1) Confidence 0.57 Published 1999 Journal Endocr Regul Section Body Doc Link 10700082 Disease Relevance 0 Pain Relevance 0
Glucocorticoids decrease phenylethanolamine N-methyltransferase mRNA expression in the immature foetal sheep adrenal.
Negative_regulation (decrease) of Transcription (expression) of phenylethanolamine N-methyltransferase associated with enkephalin
2) Confidence 0.41 Published 1999 Journal J. Neuroendocrinol. Section Title Doc Link 10444314 Disease Relevance 0 Pain Relevance 0.18
Using Northern blot analysis, adrenal phenylethanolamine N-methyltransferase (PNMT) mRNA expression was found to be reduced (P<0.005) fivefold in the cortisol infused foetuses when compared with the controls, as was the relative area of the adrenal medulla which stained positively with anti-PNMT (28.1+/-2.5% vs 44.8+/-4.8%, P<0.007).
Negative_regulation (reduced) of Transcription (expression) of phenylethanolamine N-methyltransferase in adrenal medulla associated with medulla
3) Confidence 0.41 Published 1999 Journal J. Neuroendocrinol. Section Abstract Doc Link 10444314 Disease Relevance 0 Pain Relevance 0.09

General Comments

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