INT83528

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Context Info
Confidence 0.75
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.51
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn11a) plasma membrane (Scn11a) transmembrane transport (Scn11a)
Anatomy Link Frequency
sciatic nerve 1
Scn11a (Mus musculus)
Pain Link Frequency Relevance Heat
Sciatic nerve 2 99.98 Very High Very High Very High
sodium channel 9 99.44 Very High Very High Very High
Neuropeptide 2 98.70 Very High Very High Very High
nav1.3 2 92.48 High High
Spinal cord 3 91.32 High High
nociceptor 3 90.16 High High
Pain 67 88.20 High High
tetrodotoxin 5 81.28 Quite High
fibrosis 22 66.20 Quite High
allodynia 15 61.68 Quite High
Disease Link Frequency Relevance Heat
Influenza Virus Infection 61 95.52 Very High Very High Very High
Pox Virus Infection 23 94.24 High High
Pain 72 88.20 High High
Sprains And Strains 162 87.48 High High
Nervous System Injury 20 86.92 High High
Targeted Disruption 5 70.00 Quite High
Fibrosis 19 66.20 Quite High
Neuropathic Pain 62 61.68 Quite High
Disease 9 50.00 Quite Low
Ganglion Cysts 21 39.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings demonstrate a unique distribution of NaT/Scn11a and suggest some of its roles in the above-mentioned processes.
Localization (distribution) of NaT
1) Confidence 0.75 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10623609 Disease Relevance 0 Pain Relevance 0.26
These findings demonstrate a unique distribution of NaT/Scn11a and suggest some of its roles in the above-mentioned processes.
Localization (distribution) of Scn11a
2) Confidence 0.75 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10623609 Disease Relevance 0 Pain Relevance 0.26
Seven of the eight are known to be significantly regulated in L5DRGs in rats following sciatic nerve transection (Gal, Pacap, Cchl2a, Sprr1a, C-Jun, Trpv1 and Scn11a) while one is not regulated (Mmpcp1; [2]).
Localization (transection) of Scn11a in sciatic nerve associated with sciatic nerve
3) Confidence 0.73 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 0.35 Pain Relevance 0.26
Coding sequence, genomic organization, and conserved chromosomal localization of the mouse gene Scn11a encoding the sodium channel NaN.
Localization (localization) of Scn11a associated with neuropeptide and sodium channel
4) Confidence 0.71 Published 1999 Journal Genomics Section Title Doc Link 10444332 Disease Relevance 0.18 Pain Relevance 0.49
In any case, the putative resulting increase in Na+ and T-type Ca2+ currents would improve conduction and not further deteriorate it.
Localization (increase) of Na
5) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.19 Pain Relevance 0.13
The virus constructs were characterized by PCR for absence of wild-type virus and for presence of the HA and NA gene inserts (data not shown).
Localization (presence) of NA
6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922371 Disease Relevance 0.80 Pain Relevance 0

General Comments

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