INT83529

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Context Info
Confidence 0.29
First Reported 1999
Last Reported 2010
Negated 0
Speculated 8
Reported most in Abstract
Documents 8
Total Number 16
Disease Relevance 7.22
Pain Relevance 6.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Anatomy Link Frequency
sensory neurons 2
endothelial cells 2
adrenal glands 2
PGE2 2
Cpox (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hyperalgesia 3 99.90 Very High Very High Very High
Calcitonin gene-related peptide 9 99.80 Very High Very High Very High
Inflammation 52 99.76 Very High Very High Very High
electroacupuncture 9 98.94 Very High Very High Very High
qutenza 11 98.90 Very High Very High Very High
COX-2 inhibitor 4 98.58 Very High Very High Very High
acular 6 98.56 Very High Very High Very High
Pain 10 98.20 Very High Very High Very High
antagonist 7 98.12 Very High Very High Very High
Spinal cord 9 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 4 99.90 Very High Very High Very High
INFLAMMATION 55 99.76 Very High Very High Very High
Pressure And Volume Under Development 9 99.56 Very High Very High Very High
Pain 10 98.20 Very High Very High Very High
Collagenous Colitis 2 98.08 Very High Very High Very High
Disease 5 97.12 Very High Very High Very High
Stress 14 97.00 Very High Very High Very High
Post Operative Pain 6 96.52 Very High Very High Very High
Fibrosis 2 96.36 Very High Very High Very High
Pleurisy 3 95.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At 3 h after carrageenan-injection, we investigated whether the effects of a 2 Hz EA on a carrageenan-induced edema and hyperalgesia are associated with peripheral cyclooxygenase (COX) mRNA induction and prostaglandin E2 (PGE2) synthesis.
Spec (whether) Positive_regulation (associated) of Spec (whether) Positive_regulation (induction) of COX in PGE2 associated with pressure and volume under development, hyperalgesia and electroacupuncture
1) Confidence 0.29 Published 2005 Journal Int. J. Mol. Med. Section Abstract Doc Link 15942684 Disease Relevance 0.76 Pain Relevance 0.78
Increased COX-1 activity could precede the up-regulation of COX-1 protein, and spinally administered specific COX-1 inhibitors may be useful to treat postoperative pain.
Positive_regulation (precede) of Positive_regulation (up-regulation) of COX associated with perioperative pain
2) Confidence 0.24 Published 2003 Journal Pain Section Abstract Doc Link 12855310 Disease Relevance 0.35 Pain Relevance 0.85
Increased COX-1 activity could precede the up-regulation of COX-1 protein, and spinally administered specific COX-1 inhibitors may be useful to treat postoperative pain.
Positive_regulation (precede) of Positive_regulation (Increased) of COX associated with perioperative pain
3) Confidence 0.24 Published 2003 Journal Pain Section Abstract Doc Link 12855310 Disease Relevance 0.41 Pain Relevance 0.91
In contrast, COX-2 inhibitors, nimesulide and NS-398, had no effect on the exudate volume, but they increased the number of COX-2- and mPGES-1-expressing cells and extension of their dendritic processes with significant increase in the COX-2 level, which were antagonised by ketorolac.
Positive_regulation (increased) of Positive_regulation (increase) of COX associated with acular and cox-2 inhibitor
4) Confidence 0.19 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17258197 Disease Relevance 0.37 Pain Relevance 0.38
These observations strongly suggest that capsaicin-sensitive sensory neurons might release CGRP, thereby increasing the gastric tissue levels of PGI2 and PGE2 by activating COX-1 through activation of the constitutive form of NOS in rats subjected to WIR.
Spec (might) Positive_regulation (increasing) of Positive_regulation (activating) of COX in sensory neurons associated with stress, qutenza and calcitonin gene-related peptide
5) Confidence 0.18 Published 2003 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12893632 Disease Relevance 0.96 Pain Relevance 0.77
This study was designed to investigate the effects of peripherally released NO on cyclooxygenase (COX) expression/activation and production of PGs in carrageenan-induced inflammation.
Spec (investigate) Positive_regulation (expression) of Spec (investigate) Positive_regulation (/) of COX associated with inflammation
6) Confidence 0.12 Published 2004 Journal Anesthesiology Section Abstract Doc Link 15448533 Disease Relevance 0.36 Pain Relevance 0.23
This study was designed to investigate the effects of peripherally released NO on cyclooxygenase (COX) expression/activation and production of PGs in carrageenan-induced inflammation.
Spec (investigate) Positive_regulation (/) of Spec (investigate) Positive_regulation (expression) of COX associated with inflammation
7) Confidence 0.12 Published 2004 Journal Anesthesiology Section Abstract Doc Link 15448533 Disease Relevance 0.36 Pain Relevance 0.23
This study was designed to investigate the effects of peripherally released NO on cyclooxygenase (COX) expression/activation and production of PGs in carrageenan-induced inflammation.
Positive_regulation (activation) of Spec (investigate) Positive_regulation (expression) of COX associated with inflammation
8) Confidence 0.12 Published 2004 Journal Anesthesiology Section Abstract Doc Link 15448533 Disease Relevance 0.36 Pain Relevance 0.23
This study was designed to investigate the effects of peripherally released NO on cyclooxygenase (COX) expression/activation and production of PGs in carrageenan-induced inflammation.
Spec (investigate) Positive_regulation (/) of Positive_regulation (activation) of COX associated with inflammation
9) Confidence 0.12 Published 2004 Journal Anesthesiology Section Abstract Doc Link 15448533 Disease Relevance 0.36 Pain Relevance 0.23
This study was designed to investigate the effects of peripherally released NO on cyclooxygenase (COX) expression/activation and production of PGs in carrageenan-induced inflammation.
Spec (investigate) Positive_regulation (expression) of Positive_regulation (activation) of COX associated with inflammation
10) Confidence 0.12 Published 2004 Journal Anesthesiology Section Abstract Doc Link 15448533 Disease Relevance 0.36 Pain Relevance 0.23
This study was designed to investigate the effects of peripherally released NO on cyclooxygenase (COX) expression/activation and production of PGs in carrageenan-induced inflammation.
Positive_regulation (activation) of Spec (investigate) Positive_regulation (/) of COX associated with inflammation
11) Confidence 0.12 Published 2004 Journal Anesthesiology Section Abstract Doc Link 15448533 Disease Relevance 0.36 Pain Relevance 0.23
Furthermore, a 1-h incubation with IL-1beta markedly increased the inducible COX-2 mRNA level, which was inhibited by an IL-1r antagonist and dexamethasone, whereas IL-1beta showed no effect on the level of constitutive COX-1 mRNA.
Positive_regulation (increased) of Positive_regulation (inducible) of COX associated with antagonist and dexamethasone
12) Confidence 0.08 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10537081 Disease Relevance 0.38 Pain Relevance 0.83
Inflammatory challenges trigger the cerebral upregulation of Cox 2, particularly in venule endothelial cells, and the subsequent production of PGE2.
Positive_regulation (trigger) of Positive_regulation (upregulation) of Cox in endothelial cells associated with inflammation
13) Confidence 0.08 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2292143 Disease Relevance 0.43 Pain Relevance 0.13
For this reason, it can be concluded that the activation of COX-2 and increase in PGE2 synthesis have a basic significance in the response of the adrenal glands to LPS.
Positive_regulation (activation) of Positive_regulation (activation) of COX in adrenal glands
14) Confidence 0.08 Published 2010 Journal Protoplasma Section Body Doc Link PMC2947012 Disease Relevance 0 Pain Relevance 0.13
Through cyclooxygenase (COX)-1 and COX-2 activation, ISEMF augment intestinal ion secretion in response to certain secretagogues.
Positive_regulation (augment) of Positive_regulation (activation) of COX
15) Confidence 0.01 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 10444394 Disease Relevance 0.69 Pain Relevance 0.26
Through cyclooxygenase (COX)-1 and COX-2 activation, ISEMF augment intestinal ion secretion in response to certain secretagogues.
Positive_regulation (augment) of Positive_regulation (activation) of COX
16) Confidence 0.01 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 10444394 Disease Relevance 0.69 Pain Relevance 0.26

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