INT83531

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Context Info
Confidence 0.65
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 54
Total Number 56
Disease Relevance 26.00
Pain Relevance 7.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (KITLG) signal transduction (KITLG) extracellular space (KITLG)
extracellular region (KITLG) cell adhesion (KITLG) plasma membrane (KITLG)
Anatomy Link Frequency
stem cell 14
macrophage 3
liver 3
mast cell 3
arm 2
KITLG (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 329 100.00 Very High Very High Very High
cytokine 145 100.00 Very High Very High Very High
Paracetamol 15 99.88 Very High Very High Very High
endometriosis 168 99.78 Very High Very High Very High
interstitial cystitis 16 99.30 Very High Very High Very High
Inflammation 360 98.62 Very High Very High Very High
Osteoarthritis 52 98.56 Very High Very High Very High
ischemia 6 96.56 Very High Very High Very High
antagonist 14 96.32 Very High Very High Very High
Arthritis 52 95.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 329 100.00 Very High Very High Very High
Leukemia 16 99.92 Very High Very High Very High
Myeloid Leukemia 107 99.84 Very High Very High Very High
Stomach Cancer 252 99.80 Very High Very High Very High
Endometriosis 224 99.78 Very High Very High Very High
Breast Cancer 42 99.60 Very High Very High Very High
Pancreatic Cancer 21 99.60 Very High Very High Very High
Cancer 294 99.52 Very High Very High Very High
Pancreatitis 12 99.52 Very High Very High Very High
Interstitial Cystitis 16 99.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Soluble SCF mRNA expression was 5 times higher than the expression of mSCF mRNA.
Gene_expression (expression) of SCF
1) Confidence 0.65 Published 2006 Journal J. Urol. Section Body Doc Link 16407046 Disease Relevance 0.14 Pain Relevance 0
The concept of G-SCF priming in AML was based on preclinical studies suggesting that G-SCF and GM-SCF administered prior to chemotherapy induce proliferation of AML cells which sensitizes them to cell cycle–specific agents, as cytarabine [38].
Gene_expression (priming) of SCF associated with myeloid leukemia
2) Confidence 0.65 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2902223 Disease Relevance 0.55 Pain Relevance 0
CONCLUSIONS: To our knowledge these findings demonstrate for the first time that HDSMCs express and release MCP-1 and IL-6, and show relatively high expression of soluble SCF.
Gene_expression (expression) of SCF
3) Confidence 0.61 Published 2006 Journal J. Urol. Section Body Doc Link 16407046 Disease Relevance 0 Pain Relevance 0
Soluble SCF mRNA expression was 5 times higher than the expression of mSCF mRNA.
Gene_expression (expression) of SCF mRNA
4) Confidence 0.61 Published 2006 Journal J. Urol. Section Body Doc Link 16407046 Disease Relevance 0.14 Pain Relevance 0
Expression of CD117, c-kit and the stem cell factor (SCF) receptor
Gene_expression (Expression) of SCF in stem cell
5) Confidence 0.52 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.07 Pain Relevance 0
We investigated whether HDSMCs are capable of expressing and releasing MCP-1, IL-6 and SCF in response to IL-4, IL-13, IL-1beta and tumor necrosis factor-alpha.
Gene_expression (expressing) of SCF associated with necrosis and cancer
6) Confidence 0.47 Published 2006 Journal J. Urol. Section Abstract Doc Link 16407046 Disease Relevance 0.60 Pain Relevance 0.09
Expression of CD117, c-kit and the stem cell factor (SCF) receptor
Gene_expression (Expression) of stem cell factor in stem cell
7) Confidence 0.45 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.07 Pain Relevance 0
In the initial studies, we identified that the liver produces relatively high constitutive levels of SCF.
Gene_expression (produces) of SCF in liver
8) Confidence 0.41 Published 2003 Journal Lab. Invest. Section Abstract Doc Link 12594235 Disease Relevance 0.43 Pain Relevance 0.41
Upon administration of acetaminophen, the levels of SCF fell dramatically, correlating to damage within the liver.
Gene_expression (levels) of SCF in liver associated with paracetamol
9) Confidence 0.41 Published 2003 Journal Lab. Invest. Section Abstract Doc Link 12594235 Disease Relevance 0.42 Pain Relevance 0.41
This study reports an expression of the protooncogene c-kit and its ligand stem cell factor (SCF) in gastric carcinoma cell lines [18].
Gene_expression (expression) of stem cell factor in stem cell associated with stomach cancer
10) Confidence 0.40 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.12 Pain Relevance 0
Singular CD117 expression or in combination with that of SCF is noted in several hematopoetic tumors including mast cell leukemia, acute myelogenous leukemia, and other myeloproliferative disorders [10].
Gene_expression (expression) of SCF in mast cell associated with myeloproliferative disorder, cancer, acute myeloid leukemia and mast cell leukemia
11) Confidence 0.40 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.90 Pain Relevance 0
This study reports an expression of the protooncogene c-kit and its ligand stem cell factor (SCF) in gastric carcinoma cell lines [18].
Gene_expression (expression) of SCF in stem cell associated with stomach cancer
12) Confidence 0.40 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.12 Pain Relevance 0
When the liver was allowed to regenerate, the levels of SCF again correlated with the liver regeneration.
Gene_expression (levels) of SCF in liver
13) Confidence 0.35 Published 2003 Journal Lab. Invest. Section Abstract Doc Link 12594235 Disease Relevance 0.41 Pain Relevance 0.42
One study reports a co expression of c-kit and stem cell factor genes in breast carcinoma and a possible autocrine activation of these cancer cells [20].
Gene_expression (expression) of stem cell factor in stem cell associated with cancer and breast cancer
14) Confidence 0.35 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.54 Pain Relevance 0.04
, VEGF, and stem cell factor (SCF), are expressed at abnormally high levels in patients with pterygium.4,5 In addition, we previously reported that bone marrow-derived stem and progenitor cells are involved in the pathogenesis of pterygium.6
Gene_expression (expressed) of SCF in stem cell associated with conjunctiva disease
15) Confidence 0.35 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628011 Disease Relevance 0.88 Pain Relevance 0.13
, VEGF, and stem cell factor (SCF), are expressed at abnormally high levels in patients with pterygium.4,5 In addition, we previously reported that bone marrow-derived stem and progenitor cells are involved in the pathogenesis of pterygium.6
Gene_expression (expressed) of stem cell factor in stem cell associated with conjunctiva disease
16) Confidence 0.35 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628011 Disease Relevance 0.89 Pain Relevance 0.13
The KDQOL-SF™ is available in English and was translated into Mandarin Chinese and Malay (Singapore version) by the KDQOL-SF™ group and RAND [15,16].
Gene_expression (available) of KDQOL-SF
17) Confidence 0.34 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC3014913 Disease Relevance 0.50 Pain Relevance 0
The KDQOL-SF™ is available in English and was translated into Mandarin Chinese and Malay (Singapore version) by the KDQOL-SF™ group and RAND [15,16].
Gene_expression (group) of KDQOL-SF
18) Confidence 0.30 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC3014913 Disease Relevance 0.53 Pain Relevance 0
In this system, constitutive expression of SCF by epidermal keratinocytes results in retention of melanocytes in the interfollicular basal layer and pigmentation of the epidermis itself.
Gene_expression (expression) of SCF in pigmentation
19) Confidence 0.25 Published 2009 Journal Pigment Cell Melanoma Res Section Abstract Doc Link 19682281 Disease Relevance 0.18 Pain Relevance 0.08
The K14-SCF transgenic murine model of variant pigmentation is based on epidermal expression of stem cell factor (SCF) on the C57BL/6J background.
Gene_expression (expression) of SCF in stem cell associated with targeted disruption
20) Confidence 0.25 Published 2009 Journal Pigment Cell Melanoma Res Section Abstract Doc Link 19682281 Disease Relevance 0.18 Pain Relevance 0.07

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