INT83553

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 6
Disease Relevance 4.12
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Agtr1a) aging (Agtr1a) Golgi apparatus (Agtr1a)
plasma membrane (Agtr1a) cytoplasm (Agtr1a) signal transducer activity (Agtr1a)
Anatomy Link Frequency
sciatic nerve 2
vasculature 2
peripheral nerve 2
DRG 2
Agtr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 60 98.48 Very High Very High Very High
dorsal root ganglion 284 98.34 Very High Very High Very High
antagonist 12 97.02 Very High Very High Very High
agonist 12 85.28 High High
Peripheral nerve injury 12 84.44 Quite High
Neuropathic pain 20 83.84 Quite High
Hyperalgesia 4 83.24 Quite High
adenocard 88 82.52 Quite High
hyperexcitability 24 75.64 Quite High
withdrawal 32 62.64 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 9 99.46 Very High Very High Very High
Neuropathic Pain 76 99.36 Very High Very High Very High
Nerve Compression Syndromes 180 98.54 Very High Very High Very High
Ganglion Cysts 288 98.34 Very High Very High Very High
Nociception 28 90.36 High High
Myocardial Infarction 47 89.40 High High
Nervous System Injury 16 84.44 Quite High
Hyperalgesia 4 83.24 Quite High
Peripheral Neuropathy 12 56.80 Quite High
Injury 28 51.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of angiotensin II are mediated through its stimulation of AT1 and AT2 receptors.
Positive_regulation (mediated) of Positive_regulation (stimulation) of AT1
1) Confidence 0.59 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291334 Disease Relevance 0.38 Pain Relevance 0.05
On the contrary, intrarenal angiotensin IV infusion produced vasoconstriction of the renal vasculature, mediated by activation of AT1 receptors.
Positive_regulation (mediated) of Positive_regulation (activation) of AT1 in vasculature associated with increased venous pressure under development
2) Confidence 0.49 Published 1999 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 10445671 Disease Relevance 0.10 Pain Relevance 0
In conclusion, we demonstrated that DRG neurons exhibit increased metabolic rates, increased extracellular ATP levels and increased A1R activation on the side of neuropathy induced by sciatic nerve entrapment.
Positive_regulation (increased) of Positive_regulation (activation) of A1R in sciatic nerve associated with dorsal root ganglion, neuropathic pain, nerve compression syndromes and sciatic nerve
3) Confidence 0.04 Published 2008 Journal Mol Pain Section Body Doc Link PMC2630978 Disease Relevance 1.10 Pain Relevance 0.49
In DRG ipsilateral to SNE, adding a selective A1R antagonist, 8-cyclopentyl-1,3-dipropylxanthine (30 nM), further increased basal ATP levels and relieved the blockade of KCl-evoked ATP release suggesting that increased A1R activation attenuates evoked ATP release in neurons ipsilateral to SNE.
Positive_regulation (increased) of Positive_regulation (activation) of A1R in DRG associated with antagonist and nerve compression syndromes
4) Confidence 0.04 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2630978 Disease Relevance 0.99 Pain Relevance 0.31
These data suggest that peripheral nerve entrapment increases DRG metabolism and ATP release, which in turn is modulated by increased A1R activation.



Positive_regulation (increased) of Positive_regulation (activation) of A1R in peripheral nerve associated with nerve compression syndromes
5) Confidence 0.04 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2630978 Disease Relevance 0.57 Pain Relevance 0.14
These data support our hypothesis that blockade of evoked ATP release is caused by increased A1R activation.
Positive_regulation (increased) of Positive_regulation (activation) of A1R
6) Confidence 0.04 Published 2008 Journal Mol Pain Section Body Doc Link PMC2630978 Disease Relevance 0.98 Pain Relevance 0.39

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox