INT8357

Context Info Confidence 0.75 First Reported 1984 Last Reported 2011 Negated 3 Speculated 3 Reported most in Body Documents 153 Total Number 156 Disease Relevance 77.26 Pain Relevance 68.66

extracellular space (KNG1) extracellular region (KNG1) plasma membrane (KNG1)

Anatomy Link Frequency plasma 11 urine 7 blood 4 nociceptors 4 ovary 3 KNG1 (Homo sapiens)

Pain Link Frequency Relevance Heat bradykinin 1206 100.00 Inflammation 689 100.00 Pain 496 100.00 agonist 250 100.00 b2 receptor 233 100.00 antagonist 199 100.00 substance P 154 100.00 Enkephalin 137 100.00 Nerve growth factor 57 100.00 Serotonin 46 100.00

Disease Link Frequency Relevance Heat INFLAMMATION 779 100.00 Pain 521 100.00 Weight Loss 213 100.00 Hyperalgesia 134 100.00 Hypersensitivity 56 99.96 Pruritus 14 99.96 Hereditary Angioedema 622 99.92 Cancer 540 99.92 Targeted Disruption 74 99.88 Brain Tumor 60 99.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Previous studies performed on serum and plasma samples have shown that the expression of kininogen-1 was significantly reduced in patients with gastrointestinal cancer [21], breast cancer [22] and two different types of cervical cancer [23].

Gene_expression (expression) of kininogen-1 in plasma associated with cervical cancer, breast cancer and gastrointestinal neoplasms

1) Confidence 0.75 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 0.94 Pain Relevance 0

Like CD59, kininogen-1 is also detectable in the urine of healthy individuals.

Gene_expression (detectable) of kininogen-1 in urine

2) Confidence 0.75 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 0.86 Pain Relevance 0

However, the aberrant kininogen-1 expression is apparently not cancer-specific since decreased levels of the protein had previously been reported in the urine of patients with chronic pancreatitis [14], interstitial cystitis [25] and IgA nephropathy [26], although the cause for the altered levels of kininogen-1 in these diseases may have been different.

Gene_expression (expression) of kininogen-1 in urine associated with cancer, renal disease, disease, interstitial cystitis and chronic pancreatitis

3) Confidence 0.75 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 1.28 Pain Relevance 0.19

Further confirmation of the altered levels of CD59, kininogen-1 and fragments of ITIH4 and albumin in the urine of patients with ovarian carcinoma relative to those of the control subjects was performed using antibodies and a lectin that bind to the respective proteins that were blotted onto membranes.

Gene_expression (levels) of kininogen-1 in urine associated with ovarian cancer

4) Confidence 0.75 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 0.46 Pain Relevance 0

BACKGROUND: Endogenous production of bradykinin (BK) has been postulated to cause hemodynamic changes and cardiac pain during myocardial ischemia, presumably because of the stimulation of cardiac afferent fibers.

Gene_expression (production) of bradykinin associated with pain, coronary artery disease, ischemia and bradykinin

5) Confidence 0.75 Published 1996 Journal J. Investig. Med. Section Abstract Doc Link 8689412 Disease Relevance 0.20 Pain Relevance 0.23

If angioedema occurs without urticaria or other symptoms of anaphylaxis, it is usually mediated by increased bradykinin synthesis (HANE, EANE) or reduced metabolism (ACE inhibitors).

Gene_expression (synthesis) of bradykinin associated with urticaria, pressure and volume under development, hereditary angioedema, anaphylaxis and bradykinin

6) Confidence 0.75 Published 2007 Journal Hautarzt Section Abstract Doc Link 18004529 Disease Relevance 1.34 Pain Relevance 0.27

CONCLUSIONS: Our data indicate that in patients with unstable angina pectoris, intracoronary thrombus formation is associated with a hypercoagulative state, including activation of the contact phase and of the kallikrein system and increased bradykinin generation.

Gene_expression (generation) of bradykinin

7) Confidence 0.75 Published 1995 Journal Circulation Section Body Doc Link 7743613 Disease Relevance 0 Pain Relevance 0

[The assessment of expression of kininogen and bradykinin receptors genes in different vulvar pathologies by QPCR (TaqMan)].

Gene_expression (expression) of bradykinin associated with bradykinin

8) Confidence 0.75 Published 2001 Journal Ginekol. Pol. Section Title Doc Link 11757483 Disease Relevance 0.19 Pain Relevance 0.28

The data are consistent with the hypothesis, that these mitotic active keratinocytes express bradykinin binding sites, that fulfil the pharmacological criteria for true receptors.

Gene_expression (express) of bradykinin in keratinocytes associated with bradykinin

9) Confidence 0.71 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7498312 Disease Relevance 0.17 Pain Relevance 0.79

The combinations of serotonin and bradykinin produce experimental muscle pain and muscular hyperalgesia to mechanical stimuli.

Gene_expression (produce) of bradykinin in muscle associated with pain, hyperalgesia, bradykinin, serotonin and myalgia

10) Confidence 0.67 Published 1999 Journal Pain Section Abstract Doc Link 10422653 Disease Relevance 0.64 Pain Relevance 1.31

The tachyphylaxis produced by bradykinin and capsaicin seems to reflect the depletion of messenger peptides from the C-fibres.

Gene_expression (produced) of bradykinin associated with c fibre, qutenza and bradykinin

11) Confidence 0.66 Published 1992 Journal Br. J. Dermatol. Section Abstract Doc Link 1371395 Disease Relevance 0.23 Pain Relevance 1.64

Intra-articular morphine resulted in a significant decrease in synovial white blood cell count, prostaglandin E(2) and bradykinin levels and improvement in clinical lameness, kinematic and behavioural parameters, compared to placebo treatment.

Gene_expression (levels) of bradykinin in articular

12) Confidence 0.66 Published 2010 Journal Equine Vet. J. Section Body Doc Link 20636777 Disease Relevance 0 Pain Relevance 0

Bradykinin and its active metabolites are produced at the sites of their actions by kallikreins.

Gene_expression (produced) of Bradykinin associated with bradykinin

13) Confidence 0.66 Published 1990 Journal Med Res Rev Section Abstract Doc Link 2158607 Disease Relevance 0.17 Pain Relevance 0.26

In view of these previous reports, it was not surprising to find similar reduced levels of kininogen-1 in the urine of patients with ovarian carcinoma in this study.

Gene_expression (levels) of kininogen-1 in urine associated with ovarian cancer

14) Confidence 0.65 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 1.29 Pain Relevance 0.16

Furthermore, the B2R ligand bradykinin (BK) is able to induce NO generation in resident EC, as well as O2?

Gene_expression (able) of bradykinin associated with bradykinin

15) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887352 Disease Relevance 0.28 Pain Relevance 0.17

Elevated formation of bradykinin (BK) and Lys-BK or kallidin (KD) and their carboxypeptidase metabolites desArg(9)BK and desArg(10)KD is evident at sites of inflammation.

Gene_expression (formation) of bradykinin associated with inflammation and bradykinin

16) Confidence 0.65 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10419551 Disease Relevance 0.25 Pain Relevance 0.57

PURPOSE: To compare levels of bradykinin (BK), leukotriene B4 (LTB4), prostaglandin E2 (PGE2), and substance P (SP) between successful and unsuccessful cases of arthrocentesis of temporomandibular joint disorders (TMDs).

Gene_expression (levels) of bradykinin in temporomandibular joint associated with snapping jaw, bradykinin and substance p

17) Confidence 0.65 Published 2007 Journal J. Oral Maxillofac. Surg. Section Abstract Doc Link 17236928 Disease Relevance 0.17 Pain Relevance 0.34

Bradykinin B1 receptors also produce inflammation and pain.

Gene_expression (produce) of Bradykinin associated with pain, inflammation and bradykinin

18) Confidence 0.65 Published 2000 Journal Curr Opin Chem Biol Section Abstract Doc Link 10959767 Disease Relevance 0.49 Pain Relevance 0.78

Furthermore, the B2R ligand bradykinin (BK) is able to induce NO generation in resident EC, as well as O2?

Gene_expression (ligand) of bradykinin associated with bradykinin

19) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887352 Disease Relevance 0.23 Pain Relevance 0.17

Typical substrates are the enkephalines, NPY, CCK, bradykinin, angiotensin, bombesin, ANP, the insulin chain, substance P [11], and the ”Alzheimer-peptide” ?

Gene_expression (chain) of bradykinin associated with bradykinin and substance p

20) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940827 Disease Relevance 0.80 Pain Relevance 0.10

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