INT8357
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Previous studies performed on serum and plasma samples have shown that the expression of kininogen-1 was significantly reduced in patients with gastrointestinal cancer [21], breast cancer [22] and two different types of cervical cancer [23]. | |||||||||||||||
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Like CD59, kininogen-1 is also detectable in the urine of healthy individuals. | |||||||||||||||
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However, the aberrant kininogen-1 expression is apparently not cancer-specific since decreased levels of the protein had previously been reported in the urine of patients with chronic pancreatitis [14], interstitial cystitis [25] and IgA nephropathy [26], although the cause for the altered levels of kininogen-1 in these diseases may have been different. | |||||||||||||||
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Further confirmation of the altered levels of CD59, kininogen-1 and fragments of ITIH4 and albumin in the urine of patients with ovarian carcinoma relative to those of the control subjects was performed using antibodies and a lectin that bind to the respective proteins that were blotted onto membranes. | |||||||||||||||
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BACKGROUND: Endogenous production of bradykinin (BK) has been postulated to cause hemodynamic changes and cardiac pain during myocardial ischemia, presumably because of the stimulation of cardiac afferent fibers. | |||||||||||||||
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If angioedema occurs without urticaria or other symptoms of anaphylaxis, it is usually mediated by increased bradykinin synthesis (HANE, EANE) or reduced metabolism (ACE inhibitors). | |||||||||||||||
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CONCLUSIONS: Our data indicate that in patients with unstable angina pectoris, intracoronary thrombus formation is associated with a hypercoagulative state, including activation of the contact phase and of the kallikrein system and increased bradykinin generation. | |||||||||||||||
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[The assessment of expression of kininogen and bradykinin receptors genes in different vulvar pathologies by QPCR (TaqMan)]. | |||||||||||||||
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The data are consistent with the hypothesis, that these mitotic active keratinocytes express bradykinin binding sites, that fulfil the pharmacological criteria for true receptors. | |||||||||||||||
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The combinations of serotonin and bradykinin produce experimental muscle pain and muscular hyperalgesia to mechanical stimuli. | |||||||||||||||
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The tachyphylaxis produced by bradykinin and capsaicin seems to reflect the depletion of messenger peptides from the C-fibres. | |||||||||||||||
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Intra-articular morphine resulted in a significant decrease in synovial white blood cell count, prostaglandin E(2) and bradykinin levels and improvement in clinical lameness, kinematic and behavioural parameters, compared to placebo treatment. | |||||||||||||||
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Bradykinin and its active metabolites are produced at the sites of their actions by kallikreins. | |||||||||||||||
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In view of these previous reports, it was not surprising to find similar reduced levels of kininogen-1 in the urine of patients with ovarian carcinoma in this study. | |||||||||||||||
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Furthermore, the B2R ligand bradykinin (BK) is able to induce NO generation in resident EC, as well as O2? | |||||||||||||||
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Elevated formation of bradykinin (BK) and Lys-BK or kallidin (KD) and their carboxypeptidase metabolites desArg(9)BK and desArg(10)KD is evident at sites of inflammation. | |||||||||||||||
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PURPOSE: To compare levels of bradykinin (BK), leukotriene B4 (LTB4), prostaglandin E2 (PGE2), and substance P (SP) between successful and unsuccessful cases of arthrocentesis of temporomandibular joint disorders (TMDs). | |||||||||||||||
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Bradykinin B1 receptors also produce inflammation and pain. | |||||||||||||||
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Furthermore, the B2R ligand bradykinin (BK) is able to induce NO generation in resident EC, as well as O2? | |||||||||||||||
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Typical substrates are the enkephalines, NPY, CCK, bradykinin, angiotensin, bombesin, ANP, the insulin chain, substance P [11], and the Alzheimer-peptide ? | |||||||||||||||
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