INT8358

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 25
Total Number 25
Disease Relevance 11.79
Pain Relevance 21.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CALCA) aging (CALCA) extracellular region (CALCA)
nucleus (CALCA) intracellular (CALCA) cell-cell signaling (CALCA)
Anatomy Link Frequency
muscle 4
nerve 4
sensory neurons 2
spinal cord 2
trigeminal nerve 2
CALCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 254 100.00 Very High Very High Very High
substance P 14 100.00 Very High Very High Very High
tetrodotoxin 12 100.00 Very High Very High Very High
Clonidine 11 100.00 Very High Very High Very High
fifth nerve 10 100.00 Very High Very High Very High
Triptan 88 99.98 Very High Very High Very High
Botox 37 99.98 Very High Very High Very High
Somatostatin 12 99.84 Very High Very High Very High
withdrawal 30 99.72 Very High Very High Very High
Pain 226 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 249 99.64 Very High Very High Very High
Headache 310 99.60 Very High Very High Very High
Gallstones 20 99.60 Very High Very High Very High
Disease 9 99.20 Very High Very High Very High
Pressure And Volume Under Development 8 99.20 Very High Very High Very High
Increased Venous Pressure Under Development 28 98.12 Very High Very High Very High
INFLAMMATION 11 97.92 Very High Very High Very High
Ganglion Cysts 36 97.68 Very High Very High Very High
Aids-related Complex 1 96.20 Very High Very High Very High
Neurogenic Inflammation 11 94.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Extrinsic denervation decreased basal CGRP release and abolished CGRP release and peristaltic responses normally elicited by muscle stretch but not CGRP release or peristaltic responses elicited by mucosal stimulation.
Negative_regulation (abolished) of Localization (release) of CGRP in muscle associated with calcitonin gene-related peptide
1) Confidence 0.59 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7912896 Disease Relevance 0.05 Pain Relevance 0.58
Sumatriptan and indomethacin inhibit the NO response by inhibiting trigeminal activation and calcitonin gene-related peptide (CGRP) release.
Negative_regulation (inhibiting) of Localization (release) of CGRP associated with sumatriptan and calcitonin gene-related peptide
2) Confidence 0.59 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12354573 Disease Relevance 0.36 Pain Relevance 0.64
Recently, the serotonin Type 1 agonists have been shown to cause a prolonged increase in intracellular Ca(2+) in trigeminal ganglia neurons and an increased phosphatase activity that can repress stimulated CGRP secretion and transcription.
Negative_regulation (repress) of Localization (secretion) of CGRP in neurons associated with agonist, serotonin and calcitonin gene-related peptide
3) Confidence 0.57 Published 2002 Journal Pharmacol. Ther. Section Abstract Doc Link 12191595 Disease Relevance 0.81 Pain Relevance 1.18
Further studies are required to determine the optimal dose of IV acetaminophen to control rocuronium-induced withdrawal movement and suppress CGRP and PG E2 release.



Negative_regulation (suppress) of Localization (release) of CGRP associated with paracetamol, withdrawal and calcitonin gene-related peptide
4) Confidence 0.57 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2908220 Disease Relevance 0.29 Pain Relevance 1.34
Extrinsic denervation decreased basal CGRP release and abolished CGRP release and peristaltic responses normally elicited by muscle stretch but not CGRP release or peristaltic responses elicited by mucosal stimulation.
Negative_regulation (decreased) of Localization (release) of CGRP in muscle associated with calcitonin gene-related peptide
5) Confidence 0.51 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7912896 Disease Relevance 0.05 Pain Relevance 0.59
Release of CGRP from diseased strips was abolished by TTX and inhibited by SS to degrees similar to normal tissue.
Negative_regulation (abolished) of Localization (Release) of CGRP associated with tetrodotoxin, somatostatin and calcitonin gene-related peptide
6) Confidence 0.51 Published 1995 Journal J. Surg. Res. Section Abstract Doc Link 7791341 Disease Relevance 0.46 Pain Relevance 0.85
During a migraine attack, there is a release of CGRP in conjunction with the head pain, and triptan administration abolishes both the CGRP release and the pain at the same time.
Negative_regulation (abolishes) of Localization (release) of CGRP in head associated with pain, migraine, triptan, headache and calcitonin gene-related peptide
7) Confidence 0.43 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11245850 Disease Relevance 0.49 Pain Relevance 0.99
It is suggested that the HO. can deplete endogenous CGRP localized prejunctionally and also damage CGRP-induced relaxation of canine lingual artery preparations that is caused by activation of ATP-sensitive K+ channels at postjunctional sites.
Negative_regulation (deplete) of Localization (localized) of CGRP in lingual artery associated with calcitonin gene-related peptide
8) Confidence 0.43 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8996233 Disease Relevance 0 Pain Relevance 0.39
Impaired release of gallbladder calcitonin gene-related peptide in human gallstone disease.
Negative_regulation (Impaired) of Localization (release) of calcitonin associated with disease, gallstones and calcitonin gene-related peptide
9) Confidence 0.43 Published 1995 Journal J. Surg. Res. Section Title Doc Link 7791341 Disease Relevance 0.53 Pain Relevance 0.59
Sumatriptan and indomethacin inhibit the NO response by inhibiting trigeminal activation and calcitonin gene-related peptide (CGRP) release.
Negative_regulation (inhibiting) of Localization (release) of calcitonin gene-related peptide associated with sumatriptan and calcitonin gene-related peptide
10) Confidence 0.43 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12354573 Disease Relevance 0.36 Pain Relevance 0.64
L-NAME treatment could also inhibit clonidine-induced CGRP synthesis and secretion concomitantly with the decreased NO content in culture medium.
Negative_regulation (inhibit) of Localization (secretion) of CGRP associated with calcitonin gene-related peptide and clonidine
11) Confidence 0.42 Published 2009 Journal Peptides Section Abstract Doc Link 19520131 Disease Relevance 0 Pain Relevance 1.18
Furthermore, it has also been reported that capsaicin-treated pigs significantly increase mean arterial blood pressure compared with controls and that the decrease in CGRP synthesis and release contributes to the elevated blood pressure.
Negative_regulation (decrease) of Localization (release) of CGRP in blood associated with pressure and volume under development, qutenza and calcitonin gene-related peptide
12) Confidence 0.42 Published 2009 Journal Int. J. Cardiol. Section Abstract Doc Link 18280595 Disease Relevance 0.69 Pain Relevance 0.83
Finally, the ethanol-induced increase in CGRP release from guinea-pig isolated and perfused hearts and from slices of porcine coronary arteries was abolished by capsaicin-desensitization and by capsazepine.
Negative_regulation (abolished) of Localization (release) of CGRP in hearts
13) Confidence 0.41 Published 2006 Journal Cardiovasc. Res. Section Body Doc Link 16579978 Disease Relevance 0.07 Pain Relevance 0
In addition, triptans may bind to presynaptic 5-HT1B/1D receptors on trigeminal afferents to inhibit nerve activity and hence reduce CGRP release. 5-HT1B/1D receptors were found on trigeminal sensory fibers [19], trigeminal ganglion cells [20] and in the trigemino-cerebrovascular system in man [21].
Negative_regulation (reduce) of Localization (release) of CGRP in nerve associated with ganglion cysts, trigeminal ganglion, triptan and calcitonin gene-related peptide
14) Confidence 0.40 Published 2008 Journal J Headache Pain Section Body Doc Link PMC2245994 Disease Relevance 0.95 Pain Relevance 1.41
Release of CGRP from diseased strips was abolished by TTX and inhibited by SS to degrees similar to normal tissue.
Negative_regulation (inhibited) of Localization (Release) of CGRP associated with tetrodotoxin, somatostatin and calcitonin gene-related peptide
15) Confidence 0.37 Published 1995 Journal J. Surg. Res. Section Abstract Doc Link 7791341 Disease Relevance 0.46 Pain Relevance 0.85
Impaired release of gallbladder calcitonin gene-related peptide in human gallstone disease.
Negative_regulation (Impaired) of Localization (release) of gene-related peptide associated with disease, gallstones and calcitonin gene-related peptide
16) Confidence 0.37 Published 1995 Journal J. Surg. Res. Section Title Doc Link 7791341 Disease Relevance 0.54 Pain Relevance 0.60
The results obtained show that the distribution pattern of GAP-43 in the areas examined varies with age and that the immunohistochemical detectability of the protein persists in discrete subregions of the trigeminal and cuneate nuclei of the adult, where its localization closely matches that of SP and CGRP.
Negative_regulation (matches) of Localization (localization) of CGRP associated with calcitonin gene-related peptide and substance p
17) Confidence 0.36 Published 1995 Journal Ital J Anat Embryol Section Abstract Doc Link 11322293 Disease Relevance 0 Pain Relevance 0.38
By stimulating 5-HT1B/1D receptors, triptans inhibit the release of CGRP from the perivascular nerve terminals and the trigeminal ganglion cells.
Negative_regulation (inhibit) of Localization (release) of CGRP in nerve associated with ganglion cysts, trigeminal ganglion, triptan and calcitonin gene-related peptide
18) Confidence 0.35 Published 2008 Journal J Headache Pain Section Body Doc Link PMC2245994 Disease Relevance 0.93 Pain Relevance 1.20
In animal models it inhibits trigeminal nerve firing and calcitonin gene-related peptide release which play a pivotal role in migraine pathophysiology.
Negative_regulation (inhibits) of Localization (release) of calcitonin in trigeminal nerve associated with fifth nerve, migraine and calcitonin gene-related peptide
19) Confidence 0.31 Published 2003 Journal Cephalalgia Section Abstract Doc Link 12716347 Disease Relevance 0.73 Pain Relevance 0.69
In addition, the effects of capsaicin were examined as it is known to release (and to deplete) SP and calcitonin gene-related peptide from C-fibres.
Negative_regulation (deplete) of Localization (release) of calcitonin associated with c fibre, qutenza, calcitonin gene-related peptide and substance p
20) Confidence 0.29 Published 1992 Journal Br. J. Dermatol. Section Abstract Doc Link 1371395 Disease Relevance 0.22 Pain Relevance 0.95

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox