INT83596

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Context Info
Confidence 0.76
First Reported 1999
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 6
Total Number 9
Disease Relevance 2.22
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ptk2) nucleolus (Ptk2) cytoskeleton (Ptk2)
nucleus (Ptk2) extracellular matrix organization (Ptk2) microtubule organizing center (Ptk2)
Ptk2 (Rattus norvegicus)
Ptk2 - Y397F (1)
Pain Link Frequency Relevance Heat
lidocaine 20 99.60 Very High Very High Very High
analgesia 1 91.96 High High
agonist 1 89.08 High High
anesthesia 2 86.16 High High
peptic ulcer disease 2 70.84 Quite High
dorsal root ganglion 56 31.28 Quite Low
opioid receptor 16 5.00 Very Low Very Low Very Low
Dynorphin 12 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 12 100.00 Very High Very High Very High
Death 6 97.40 Very High Very High Very High
Stress 6 92.40 High High
Sleep Disorders 1 91.52 High High
Sprains And Strains 2 79.40 Quite High
Ulcers 10 75.00 Quite High
Disease 2 70.84 Quite High
Cytomegalovirus Infection 4 42.48 Quite Low
Ganglion Cysts 56 31.28 Quite Low
Pain 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The authors hypothesized that dexmedetomidine increases the expression of active (autophosphorylated) focal adhesion kinase (FAK), a nonreceptor tyrosine kinase playing a pivotal role in cellular plasticity and survival.
Gene_expression (expression) of FAK associated with adhesions
1) Confidence 0.76 Published 2005 Journal Anesthesiology Section Abstract Doc Link 16249671 Disease Relevance 0.27 Pain Relevance 0.14
Here, we compared the effects of lidocaine and bupivacaine on FAK phosphorylation and cleaved caspase 3 expression in rat hippocampal slices.
Gene_expression (expression) of FAK associated with lidocaine
2) Confidence 0.67 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 17179255 Disease Relevance 0.19 Pain Relevance 0.72
Caspase 3 expression and FAK phosphorylation were examined by immunoblotting.
Gene_expression (expression) of FAK
3) Confidence 0.60 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 17179255 Disease Relevance 0.17 Pain Relevance 0.85
The effect of silencing FAK was rescued by expressing siRNA-insensitive WT Flag-FAK (see Materials and methods) but not by the dominant-negative Flag-FAK-Y397F (Tsai et al., 2008).
Neg (negative) Gene_expression (expressing) of Flag-FAK
4) Confidence 0.49 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0 Pain Relevance 0
Flag-Grb7 was incubated with precipitated FAK in the presence of ?
Gene_expression (precipitated) of FAK
5) Confidence 0.49 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0 Pain Relevance 0
As shown in Fig. 5 A, EGF induced an increase in the phosphorylation of cytoplasmic Grb7, which was blocked by FAK inhibitor PF 573228 (Slack-Davis et al., 2007) and FAK inhibitor 14 (Golubovskaya et al., 2008) as well as by silencing FAK.
Gene_expression (silencing) of FAK
6) Confidence 0.49 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0 Pain Relevance 0
The effect of silencing FAK was rescued by expressing siRNA-insensitive WT Flag-FAK (see Materials and methods) but not by the dominant-negative Flag-FAK-Y397F (Tsai et al., 2008).
Neg (negative) Gene_expression (expressing) of Flag-FAK-Y397F (Y397F)
7) Confidence 0.43 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0 Pain Relevance 0
Furthermore, VacA treatment significantly reduced tyrosine phosphorylation of focal adhesion kinase (FAK) (by 45 +/- 6%; p < 0.002) and its expression in focal adhesions (73 +/- 8%; p < 0.0001).
Gene_expression (expression) of focal adhesion kinase associated with adhesions
8) Confidence 0.41 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10448099 Disease Relevance 0.80 Pain Relevance 0.07
Furthermore, VacA treatment significantly reduced tyrosine phosphorylation of focal adhesion kinase (FAK) (by 45 +/- 6%; p < 0.002) and its expression in focal adhesions (73 +/- 8%; p < 0.0001).
Gene_expression (expression) of FAK associated with adhesions
9) Confidence 0.41 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10448099 Disease Relevance 0.80 Pain Relevance 0.07

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