INT83597

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Context Info
Confidence 0.82
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 24
Disease Relevance 3.24
Pain Relevance 5.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ptk2) nucleolus (Ptk2) cytoskeleton (Ptk2)
nucleus (Ptk2) extracellular matrix organization (Ptk2) microtubule organizing center (Ptk2)
Anatomy Link Frequency
neuronal 3
nucleus 1
band 1
hippocampus 1
Ptk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
lidocaine 62 99.92 Very High Very High Very High
Hippocampus 3 99.52 Very High Very High Very High
Kinase C 9 96.12 Very High Very High Very High
tetrodotoxin 3 94.84 High High
anesthesia 5 93.92 High High
analgesia 8 91.08 High High
agonist 8 88.20 High High
antagonist 3 87.36 High High
opioid receptor 20 80.20 Quite High
qutenza 5 75.00 Quite High
Disease Link Frequency Relevance Heat
Adhesions 36 100.00 Very High Very High Very High
Death 10 97.40 Very High Very High Very High
Stress 7 93.16 High High
Sleep Disorders 8 90.64 High High
Sprains And Strains 2 80.16 Quite High
Ulcers 10 75.24 Quite High
Disease 2 71.60 Quite High
Ganglion Cysts 70 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lidocaine induced a concentration-related increase in FAK phosphorylation while the bupivacaine effect was biphasic.
Phosphorylation (phosphorylation) of FAK associated with lidocaine
1) Confidence 0.82 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 17179255 Disease Relevance 0.16 Pain Relevance 0.86
Here, we compared the effects of lidocaine and bupivacaine on FAK phosphorylation and cleaved caspase 3 expression in rat hippocampal slices.
Phosphorylation (phosphorylation) of FAK associated with lidocaine
2) Confidence 0.82 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 17179255 Disease Relevance 0.19 Pain Relevance 0.66
We have previously shown that lidocaine increases the phosphorylation of focal adhesion kinase (FAK, a nonreceptor tyrosine kinase playing a role in neuronal plasticity and cell death).
Phosphorylation (phosphorylation) of FAK in neuronal associated with lidocaine, death and adhesions
3) Confidence 0.82 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 17179255 Disease Relevance 0.20 Pain Relevance 0.59
The role of FAK phosphorylation in this effect remains to be clarified.
Phosphorylation (phosphorylation) of FAK
4) Confidence 0.82 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 17179255 Disease Relevance 0.11 Pain Relevance 0.68
Caspase 3 expression and FAK phosphorylation were examined by immunoblotting.
Phosphorylation (phosphorylation) of FAK
5) Confidence 0.82 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 17179255 Disease Relevance 0.17 Pain Relevance 0.85
We examined the effect of lidocaine on phosphorylation of the tyrosine kinase focal adhesion kinase (PP125FAK) in rat hippocampal slices by immunoblotting with both antiphosphotyrosine and specific anti-PP125FAK antibodies in the presence of tetrodotoxin (1 microM).
Phosphorylation (phosphorylation) of PP125FAK associated with tetrodotoxin, lidocaine and adhesions
6) Confidence 0.81 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15063155 Disease Relevance 0.17 Pain Relevance 0.41
Lidocaine induced a concentration-related increase in tyrosine phosphorylation of the 125-kDa band corresponding to PP125FAK phosphorylation (EC50 value=0.39+/-0.09 microM, maximal effect=169+/-28% of control, P<0.001).
Phosphorylation (phosphorylation) of PP125FAK in band associated with lidocaine
7) Confidence 0.81 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15063155 Disease Relevance 0.16 Pain Relevance 0.56
METHODS: The effects of dexmedetomidine on phospho-tyrosine FAK phosphorylation were studied first with or without various pharmacologic agents in normoxic conditions, and second in a model of pharmacologic preconditioning of slices subjected to 30 min of OGD followed by 1 h of reperfusion.
Phosphorylation (phosphorylation) of FAK
8) Confidence 0.80 Published 2005 Journal Anesthesiology Section Body Doc Link 16249671 Disease Relevance 0 Pain Relevance 0
FAK phosphorylation and caspase-3 activation were examined by immunoblotting.
Phosphorylation (phosphorylation) of FAK
9) Confidence 0.80 Published 2005 Journal Anesthesiology Section Body Doc Link 16249671 Disease Relevance 0 Pain Relevance 0
RESULTS: Dexmedetomidine produced a dose-related increase in FAK phosphorylation (187 +/- 4%, mean +/- SD, from basal level, EC50 = 0.2 microm; 95% confidence interval, 0.09-0.5 microm).
Phosphorylation (phosphorylation) of FAK
10) Confidence 0.80 Published 2005 Journal Anesthesiology Section Body Doc Link 16249671 Disease Relevance 0 Pain Relevance 0
The authors hypothesized that dexmedetomidine increases the expression of active (autophosphorylated) focal adhesion kinase (FAK), a nonreceptor tyrosine kinase playing a pivotal role in cellular plasticity and survival.
Phosphorylation (autophosphorylated) of FAK associated with adhesions
11) Confidence 0.79 Published 2005 Journal Anesthesiology Section Abstract Doc Link 16249671 Disease Relevance 0.27 Pain Relevance 0.14
We conclude that lidocaine increases phosphorylation of the tyrosine kinase PP125FAK in the rat hippocampus by a tetrotoxin (TTX)-insensitive mechanism which involves activation of PKC.
Phosphorylation (phosphorylation) of kinase PP125FAK in hippocampus associated with kinase c, hippocampus and lidocaine
12) Confidence 0.70 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15063155 Disease Relevance 0.14 Pain Relevance 0.63
In OGD conditions, a preconditioning application of dexmedetomidine (0.2 microm, 20-min application, 3 h before anoxia) significantly reduced neuronal death and cleaved caspase-3 expression and significantly attenuated the decrease in phosphorylated FAK content.
Phosphorylation (phosphorylated) of FAK in neuronal
13) Confidence 0.62 Published 2005 Journal Anesthesiology Section Body Doc Link 16249671 Disease Relevance 0 Pain Relevance 0
OGD induced a significant increase in immunoreactivity of the cleaved caspase-3 17-kd fragment (417 +/- 22; P < 0.001), a decrease in FAK phosphorylation (78 +/- 12% of control; P < 0.05), and production of significant neuronal death.
Phosphorylation (phosphorylation) of FAK in neuronal
14) Confidence 0.62 Published 2005 Journal Anesthesiology Section Body Doc Link 16249671 Disease Relevance 0 Pain Relevance 0
Increase in phosphorylation of FAK via stimulation of alpha2 adrenoceptors and decrease in cleaved caspase-3 expression correlate with dexmedetomidine-induced cell survival.


Phosphorylation (phosphorylation) of FAK
15) Confidence 0.62 Published 2005 Journal Anesthesiology Section Body Doc Link 16249671 Disease Relevance 0 Pain Relevance 0
METHODS: The effects of dexmedetomidine on phospho-tyrosine FAK phosphorylation were studied first with or without various pharmacologic agents in normoxic conditions, and second in a model of pharmacologic preconditioning of slices subjected to 30 min of OGD followed by 1 h of reperfusion.
Phosphorylation (phosphorylation) of FAK
16) Confidence 0.62 Published 2005 Journal Anesthesiology Section Body Doc Link 16249671 Disease Relevance 0 Pain Relevance 0
Finally, EGF enhanced the protein level of KOR in cells expressing WT Grb7 but not in cells expressing a phosphorylation mutant of Grb7 (DM Flag-Grb7; Fig. 5 B), concluding that EGF-stimulated KOR translation is mediated by FAK phosphorylation of cytoplasmic Grb7.
Phosphorylation (phosphorylation) of FAK
17) Confidence 0.60 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0 Pain Relevance 0
FAK could phosphorylate Grb7 and thereby release KOR mRNA for translation (Tsai et al., 2007).
Phosphorylation (phosphorylate) of FAK
18) Confidence 0.59 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0 Pain Relevance 0
Importantly, blocking FAK function failed to inhibit EGF-stimulated Grb7 and KOR mRNA export (Fig. 5 A, right), suggesting the specificity of FAK in phosphorylating cytoplasmic Grb7.
Phosphorylation (phosphorylating) of FAK
19) Confidence 0.46 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0 Pain Relevance 0
Dual action of epidermal growth factor: extracellular signal-stimulated nuclear–cytoplasmic export and coordinated translation of selected messenger RNA

EGF triggers dephosphorylation of the mRNA-binding protein Grb7 in the nucleus, leading to its export, and it also stimulates FAK, which rephosphorylates Grb7 in the cytoplasm to release its mRNA cargo for translation.


Phosphorylation (dephosphorylation) of FAK in nucleus
20) Confidence 0.46 Published 2010 Journal The Journal of Cell Biology Section Title Doc Link PMC2819679 Disease Relevance 0.06 Pain Relevance 0.04

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