INT83601

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Context Info
Confidence 0.47
First Reported 1999
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 30
Total Number 34
Disease Relevance 7.79
Pain Relevance 12.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CNR2) signal transducer activity (CNR2)
Anatomy Link Frequency
blood vessels 1
nerves 1
stellate cells 1
RBL-2H3 1
CNS 1
CNR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cannabinoid 260 100.00 Very High Very High Very High
agonist 154 100.00 Very High Very High Very High
Cannabinoid receptor 148 100.00 Very High Very High Very High
antagonist 178 99.96 Very High Very High Very High
Chronic pancreatitis 93 99.80 Very High Very High Very High
Pain 172 99.76 Very High Very High Very High
Central nervous system 34 99.50 Very High Very High Very High
Endocannabinoid 207 98.20 Very High Very High Very High
rheumatoid arthritis 104 98.08 Very High Very High Very High
Potency 10 97.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pancreatitis 96 99.80 Very High Very High Very High
Pain 219 99.76 Very High Very High Very High
Rheumatoid Arthritis 104 98.08 Very High Very High Very High
Frailty 138 97.80 Very High Very High Very High
INFLAMMATION 182 96.84 Very High Very High Very High
Immune System Diseases 7 96.56 Very High Very High Very High
Neuropathic Pain 56 95.12 Very High Very High Very High
Fibrosis 34 94.68 High High
Bordatella Infection 4 91.60 High High
Vomiting 138 90.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
None of the compounds efficiently inhibited [(14)C]anandamide hydrolysis or bound to CB2 receptors.
CB2 Binding (bound) of
1) Confidence 0.47 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10448105 Disease Relevance 0 Pain Relevance 0.11
We investigated the effect of changing the length and degree of unsaturation of the fatty acyl chain of N-(3-methoxy-4-hydroxy)-benzyl-cis-9-octadecenoamide (olvanil), a ligand of vanilloid receptors, on its capability to: (i) inhibit anandamide-facilitated transport into cells and enzymatic hydrolysis, (ii) bind to CB1 and CB2 cannabinoid receptors, and (iii) activate the VR1 vanilloid receptor.
CB2 Binding (bind) of associated with cannabinoid receptor
2) Confidence 0.47 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10448105 Disease Relevance 0 Pain Relevance 0.09
Although it does not bind with high affinity to CB1 or CB2 receptors, it exhibits some cannabimimetic actions which could be explained at least in part by entourage effects.
CB2 Neg (not) Binding (bind) of
3) Confidence 0.47 Published 1999 Journal Curr. Med. Chem. Section Abstract Doc Link 10469890 Disease Relevance 0.08 Pain Relevance 0.33
We observed that LASSBio-881 (3c) was able to bind to CB1 receptors (71% at 100microM) and also to inhibit T-cell proliferation (66% at 10microM) probably by binding to CB2 receptors, in a non-proapoptotic manner, different from anandamide (1).
CB2 Binding (binding) of in T-cell
4) Confidence 0.47 Published 2007 Journal Bioorg. Med. Chem. Section Abstract Doc Link 17275312 Disease Relevance 0.09 Pain Relevance 0.17
The present work helps characterize experimentally the ligand-binding interactions of the human CB2 (hCB2) receptor.
CB2 Binding (interactions) of
5) Confidence 0.42 Published 2008 Journal Chem. Biol. Section Abstract Doc Link 19022181 Disease Relevance 0.27 Pain Relevance 0.22
The present work helps characterize experimentally the ligand-binding interactions of the human CB2 (hCB2) receptor.
hCB2 Binding (interactions) of
6) Confidence 0.37 Published 2008 Journal Chem. Biol. Section Abstract Doc Link 19022181 Disease Relevance 0.27 Pain Relevance 0.22
This study illustrates how our overall experimental approach, "ligand-assisted protein structure" (LAPS), affords direct determination of the requirements for ligand binding to the hCB2 receptor and discrimination among the binding motifs for ligands that activate therapeutically relevant GPCRs.
hCB2 receptor Spec (determination) Binding (binding) of
7) Confidence 0.37 Published 2008 Journal Chem. Biol. Section Abstract Doc Link 19022181 Disease Relevance 0.25 Pain Relevance 0.20
These different orientations of ligand inside the binding pocket of CB1 and CB2 receptors may explain its different binding affinity in the two receptors.
CB2 Binding (binding) of
8) Confidence 0.36 Published 2008 Journal Bioorg. Med. Chem. Section Abstract Doc Link 18595717 Disease Relevance 0 Pain Relevance 0.08
The affinities of these bivalent ligands at CB1 and CB2 receptors were determined using radiolabeled binding assays.
CB2 Binding (receptors) of
9) Confidence 0.36 Published 2010 Journal J. Med. Chem. Section Abstract Doc Link 20845959 Disease Relevance 0 Pain Relevance 0.26
A new class of cannabinoid ligands was rationally designed from known aminoalkylindole agonists and showed good binding and functional activities at human CB1 and CB2 receptors.
CB2 Binding (binding) of associated with cannabinoid and agonist
10) Confidence 0.36 Published 2007 Journal J. Med. Chem. Section Abstract Doc Link 17630726 Disease Relevance 0.09 Pain Relevance 0.53
Comparative molecular dynamics simulations of the potent synthetic classical cannabinoid ligand AMG3 in solution and at binding site of the CB1 and CB2 receptors.
CB2 Binding (binding) of associated with cannabinoid
11) Confidence 0.35 Published 2008 Journal Bioorg. Med. Chem. Section Title Doc Link 18595717 Disease Relevance 0 Pain Relevance 0.31
In fact, PEA does not bind to CB1 and CB2 receptors transfected into host cells, but might be a ligand for a putative CBn receptor present in the RBL-2H3 cell line.
CB2 Neg (not) Spec (might) Binding (bind) of in RBL-2H3
12) Confidence 0.35 Published 1999 Journal Curr. Med. Chem. Section Abstract Doc Link 10469890 Disease Relevance 0.10 Pain Relevance 0.36
With the aim of investigating the structure-activity relationships (SAR) for the binding of non-classical agonists to CB1 and CB2 cannabinoid receptors, we designed and synthesized a series of indole derivatives.
CB2 Binding (binding) of associated with cannabinoid receptor and agonist
13) Confidence 0.35 Published 2010 Journal Chem Biol Drug Des Section Abstract Doc Link 19895505 Disease Relevance 0 Pain Relevance 0.33
Most of the agonists exhibit nonselective affinity for CB1/CB2 receptors, and delta9-THC and anandamide probably act as partial agonists.
CB2 Binding (affinity) of associated with agonist
14) Confidence 0.35 Published 1999 Journal Crit Rev Neurobiol Section Abstract Doc Link 10803637 Disease Relevance 0 Pain Relevance 0.61
The rank order of potency for G protein activation and effector regulation by the three agonists is similar to their apparent affinity for CB2 receptors; CP > NE > or = 2-AG.
CB2 Binding (affinity) of associated with agonist and potency
15) Confidence 0.35 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15901805 Disease Relevance 0.09 Pain Relevance 0.58
Surprisingly, in transfected CHO cells, NE exhibits a relatively high nanomolar affinity for CB2 receptors (K(i) = 480 nM), comparable to that observed for the endocannabinoid 2-arachidonoyl glycerol (2-AG) (K(i) = 1016 nM).
CB2 Binding (affinity) of in CHO associated with endocannabinoid
16) Confidence 0.33 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15901805 Disease Relevance 0 Pain Relevance 0.38
We recently found that N-alkyl amides from purple coneflower (Echinacea spp.) constitute a new class of cannabinomimetics, which specifically engage and activate the cannabinoid type-2 (CB2) receptors.
CB2 Binding (engage) of associated with cannabinoid
17) Confidence 0.33 Published 2006 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 17118807 Disease Relevance 0.14 Pain Relevance 0.46
Two CB receptors have been identified in humans (CB1 and CB2) which are recognized exclusively by cannabinoids.
CB2 Binding (recognized) of associated with cannabinoid
18) Confidence 0.32 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503671 Disease Relevance 0.77 Pain Relevance 0.73
However, there is little direct structural information pertaining to either GPCR or CB2-receptor ligand recognition and activation.
CB2 Binding (recognition) of
19) Confidence 0.31 Published 2008 Journal Chem. Biol. Section Abstract Doc Link 19022181 Disease Relevance 0.29 Pain Relevance 0.23
PA1-745, lot. no. 424-121); anti-CB2 receptor (diluted 1?
CB2 Binding (receptor) of
20) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731878 Disease Relevance 0.11 Pain Relevance 0

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