INT83602
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Western blot analysis of UV-irradiated young buttock skin revealed that the expression of TRPV1 protein was increased at 24 h (2.3-fold) and 48 h (2.4-fold) after UV irradiation. | |||||||||||||||
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Also, we found increased expression of TRPV1 in nerve fibres of elderly persons using double staining of TRPV1 and nerve fibres. | |||||||||||||||
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Increased expression of TRPV1 channel in intrinsically aged and photoaged human skin in vivo. | |||||||||||||||
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Increased expression of TRPV1 in squamous cell carcinoma of the human tongue. | |||||||||||||||
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Furthermore, statistical analysis revealed that the marked overexpression of TRPV1 found in all grades of SCC showed no correlation with the degree of malignancy of the tumours. | |||||||||||||||
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Finally, the molecular expression of TRPV1 was also identified in an SCC-derived cell line and was shown to be increased in parallel with the accelerated growth of the cells. | |||||||||||||||
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Increased TRPV1 expression in the inflamed oesophagus may mediate the heartburn in oesophagitis, and TRPV1 blockers may provide novel treatment.
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Six such compounds were synthesized and tested for calcium mobilization at recombinant TRPV1 receptors overexpressed in HEK293 cells. | |||||||||||||||
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Studies with animals that are deficient in the vanilloid (capsaicin) receptor TRPV1 have confirmed the pivotal role that TRPV1 has in the development of post-inflammatory hyperalgesia, and enhanced TRPV1 expression has been described in various human disorders. | |||||||||||||||
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Moderate keratinocyte TRPV1 expression was significantly increased in DISN compared with controls (P = 0.01).
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TRPV1 expression was significantly increased in the whole epidermal region in DISN when compared with controls (P = 0.01). | |||||||||||||||
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In conclusion, our data show that increased keratinocyte TRPV1 expression in patients with small nerve fibre neuropathy and, to a lesser extent, in DN may play a role in explaining some of the typical clinical features of increased sensitivity to noxious stimuli.
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TRPV1b overexpression negatively regulates TRPV1 responsiveness to capsaicin, heat and low pH in HEK293 cells. | |||||||||||||||
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A significant increase in vascular TRPV1 expression was observed in arterioles present in the midcoronal pulp in carious painful compared with carious asymptomatic samples (mean area +/- SEM [%] of TRPV1 to vascular labeling; 6.48% +/- 4.5% for carious asymptomatic teeth, n = 9; 31.21% +/- 9.6% for carious painful teeth, n = 9; P = .02). | |||||||||||||||
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Overexpression of TRPV1 greatly increased heat-shock-induced MMP-1 promoter activity in HEK 293 cells. | |||||||||||||||
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The results show that TRPV1 protein expression increases during RA-induced differentiation in vitro, which generates an altered intracellular Ca(2+) homeostasis. | |||||||||||||||
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TRPV1 expression increased significantly at the injury site of damaged nerves 3 days after injury and this was matched by a reduction in the proportion of fluorogold positive cells expressing TRPV1 in the ganglion. | |||||||||||||||
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Phosphorylation-induced potentiation of TRPV1 channel activity, along with an incremented TRPV1 surface expression are major events underlying the nociceptor activation and sensitization that leads to thermal hyperalgesia. | |||||||||||||||
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Thus, high doses of vanilloids (i.e. 20100 µM) do not require expression of TRPV1 for the cytotoxic effect. | |||||||||||||||
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In patients with chronic cough, increased expression of TRPV1 in airway nerves was reported [15]. | |||||||||||||||
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General Comments
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