INT83602

Context Info Confidence 0.70 First Reported 1999 Last Reported 2010 Negated 1 Speculated 2 Reported most in Abstract Documents 114 Total Number 116 Disease Relevance 51.19 Pain Relevance 56.35

cytosol (TRPV1) transport (TRPV1) plasma membrane (TRPV1) lipid metabolic process (TRPV1)

Anatomy Link Frequency nerve 31 embryonic kidney 14 sensory neurons 13 visceral 8 skin 8 TRPV1 (Homo sapiens) TRPV1 - L549M (2)

Pain Link Frequency Relevance Heat qutenza 898 100.00 Pain 463 100.00 Inflammation 347 100.00 agonist 187 100.00 nociceptor 80 100.00 TRP channel 66 100.00 Neuropeptide 50 100.00 Calcitonin gene-related peptide 40 100.00 Hyperalgesia 36 100.00 vanilloid receptor subtype 1 32 100.00

Disease Link Frequency Relevance Heat INFLAMMATION 352 100.00 Hyperalgesia 110 100.00 Death 38 100.00 Injury 62 99.98 Bone Cancer 10 99.98 Headache 2 99.98 Cough 271 99.96 Disease 150 99.92 Inflammatory Pain 24 99.92 Pain 490 99.90

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Western blot analysis of UV-irradiated young buttock skin revealed that the expression of TRPV1 protein was increased at 24 h (2.3-fold) and 48 h (2.4-fold) after UV irradiation.

Positive_regulation (increased) of Gene_expression (expression) of TRPV1 protein in skin

1) Confidence 0.70 Published 2009 Journal Exp. Dermatol. Section Abstract Doc Link 19161409 Disease Relevance 0.18 Pain Relevance 0.08

Also, we found increased expression of TRPV1 in nerve fibres of elderly persons using double staining of TRPV1 and nerve fibres.

Positive_regulation (increased) of Gene_expression (expression) of TRPV1 in nerve

2) Confidence 0.70 Published 2009 Journal Exp. Dermatol. Section Abstract Doc Link 19161409 Disease Relevance 0.13 Pain Relevance 0.05

Increased expression of TRPV1 channel in intrinsically aged and photoaged human skin in vivo.

Positive_regulation (Increased) of Gene_expression (expression) of TRPV1 in skin

3) Confidence 0.70 Published 2009 Journal Exp. Dermatol. Section Title Doc Link 19161409 Disease Relevance 0.17 Pain Relevance 0.09

Increased expression of TRPV1 in squamous cell carcinoma of the human tongue.

Positive_regulation (Increased) of Gene_expression (expression) of TRPV1 in tongue associated with skin cancer

4) Confidence 0.70 Published 2009 Journal Oral Dis Section Title Doc Link 19320840 Disease Relevance 0.19 Pain Relevance 0.09

Furthermore, statistical analysis revealed that the marked overexpression of TRPV1 found in all grades of SCC showed no correlation with the degree of malignancy of the tumours.

Positive_regulation (overexpression) of Gene_expression (overexpression) of TRPV1

5) Confidence 0.70 Published 2009 Journal Oral Dis Section Body Doc Link 19320840 Disease Relevance 0.24 Pain Relevance 0

Finally, the molecular expression of TRPV1 was also identified in an SCC-derived cell line and was shown to be increased in parallel with the accelerated growth of the cells.

Positive_regulation (increased) of Gene_expression (expression) of TRPV1

6) Confidence 0.70 Published 2009 Journal Oral Dis Section Body Doc Link 19320840 Disease Relevance 0.22 Pain Relevance 0

Increased TRPV1 expression in the inflamed oesophagus may mediate the heartburn in oesophagitis, and TRPV1 blockers may provide novel treatment.

Positive_regulation (Increased) of Gene_expression (expression) of TRPV1 in oesophagus

7) Confidence 0.70 Published 2004 Journal Eur J Gastroenterol Hepatol Section Body Doc Link 15316415 Disease Relevance 0.05 Pain Relevance 0

Six such compounds were synthesized and tested for calcium mobilization at recombinant TRPV1 receptors overexpressed in HEK293 cells.

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of TRPV1

8) Confidence 0.70 Published 2007 Journal Bioorg. Med. Chem. Section Abstract Doc Link 17616464 Disease Relevance 0 Pain Relevance 0.09

Studies with animals that are deficient in the vanilloid (capsaicin) receptor TRPV1 have confirmed the pivotal role that TRPV1 has in the development of post-inflammatory hyperalgesia, and enhanced TRPV1 expression has been described in various human disorders.

Positive_regulation (enhanced) of Gene_expression (expression) of TRPV1 associated with hyperalgesia, inflammation and qutenza

9) Confidence 0.70 Published 2005 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 16043235 Disease Relevance 0.20 Pain Relevance 0.39

Moderate keratinocyte TRPV1 expression was significantly increased in DISN compared with controls (P = 0.01).

Positive_regulation (increased) of Gene_expression (expression) of TRPV1 in keratinocyte

10) Confidence 0.70 Published 2007 Journal Histopathology Section Abstract Doc Link PMC2121152 Disease Relevance 0.60 Pain Relevance 0.35

TRPV1 expression was significantly increased in the whole epidermal region in DISN when compared with controls (P = 0.01).

Positive_regulation (increased) of Gene_expression (expression) of TRPV1 associated with disease

11) Confidence 0.70 Published 2007 Journal Histopathology Section Body Doc Link PMC2121152 Disease Relevance 0.84 Pain Relevance 0.04

In conclusion, our data show that increased keratinocyte TRPV1 expression in patients with small nerve fibre neuropathy and, to a lesser extent, in DN may play a role in explaining some of the typical clinical features of increased sensitivity to noxious stimuli.

Positive_regulation (increased) of Gene_expression (expression) of TRPV1 in nerve associated with diabetic neuropathy and neuropathic pain

12) Confidence 0.70 Published 2007 Journal Histopathology Section Body Doc Link PMC2121152 Disease Relevance 0.56 Pain Relevance 0.23

TRPV1b overexpression negatively regulates TRPV1 responsiveness to capsaicin, heat and low pH in HEK293 cells.

Positive_regulation (overexpression) of Gene_expression (overexpression) of TRPV1b associated with qutenza

13) Confidence 0.70 Published 2006 Journal J. Neurochem. Section Title Doc Link 17018028 Disease Relevance 0 Pain Relevance 0.91

A significant increase in vascular TRPV1 expression was observed in arterioles present in the midcoronal pulp in carious painful compared with carious asymptomatic samples (mean area +/- SEM [%] of TRPV1 to vascular labeling; 6.48% +/- 4.5% for carious asymptomatic teeth, n = 9; 31.21% +/- 9.6% for carious painful teeth, n = 9; P = .02).

Positive_regulation (increase) of Gene_expression (expression) of TRPV1 in teeth

14) Confidence 0.70 Published 2005 Journal J Orofac Pain Section Body Doc Link 16106719 Disease Relevance 0.06 Pain Relevance 0

Overexpression of TRPV1 greatly increased heat-shock-induced MMP-1 promoter activity in HEK 293 cells.

Positive_regulation (Overexpression) of Gene_expression (Overexpression) of TRPV1 associated with shock and metalloproteinase

15) Confidence 0.70 Published 2007 Journal J. Invest. Dermatol. Section Abstract Doc Link 17508023 Disease Relevance 0.67 Pain Relevance 0.51

The results show that TRPV1 protein expression increases during RA-induced differentiation in vitro, which generates an altered intracellular Ca(2+) homeostasis.

Positive_regulation (increases) of Gene_expression (expression) of TRPV1 associated with rheumatoid arthritis

16) Confidence 0.70 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19651168 Disease Relevance 0.66 Pain Relevance 0.17

TRPV1 expression increased significantly at the injury site of damaged nerves 3 days after injury and this was matched by a reduction in the proportion of fluorogold positive cells expressing TRPV1 in the ganglion.

Positive_regulation (increased) of Gene_expression (expression) of TRPV1 in nerves associated with ganglion cysts and injury

17) Confidence 0.70 Published 2007 Journal Eur J Pain Section Abstract Doc Link 16542859 Disease Relevance 1.03 Pain Relevance 0.15

Phosphorylation-induced potentiation of TRPV1 channel activity, along with an incremented TRPV1 surface expression are major events underlying the nociceptor activation and sensitization that leads to thermal hyperalgesia.

Positive_regulation (incremented) of Gene_expression (expression) of TRPV1 in nociceptor associated with thermal hyperalgesia and nociceptor

18) Confidence 0.70 Published 2005 Journal Pflugers Arch. Section Abstract Doc Link 15909179 Disease Relevance 1.13 Pain Relevance 1.07

Thus, high doses of vanilloids (i.e. 20–100 µM) do not require expression of TRPV1 for the cytotoxic effect.

Neg (not) Positive_regulation (require) of Gene_expression (expression) of TRPV1

19) Confidence 0.69 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566593 Disease Relevance 0.22 Pain Relevance 0.24

In patients with chronic cough, increased expression of TRPV1 in airway nerves was reported [15].

Positive_regulation (increased) of Gene_expression (expression) of TRPV1 in nerves associated with cough

20) Confidence 0.69 Published 2007 Journal Cough Section Body Doc Link PMC2174508 Disease Relevance 0.89 Pain Relevance 0.15

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