INT83607

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Context Info
Confidence 0.59
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 16
Disease Relevance 14.24
Pain Relevance 8.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CSAD) small molecule metabolic process (CSAD) lyase activity (CSAD)
cellular nitrogen compound metabolic process (CSAD)
Anatomy Link Frequency
neuronal 1
parietal cortex 1
spike 1
CSAD (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 193 100.00 Very High Very High Very High
Transcranial magnetic stimulation 3 99.76 Very High Very High Very High
Migraine 173 99.36 Very High Very High Very High
Locus ceruleus 3 97.28 Very High Very High Very High
Raphe 1 96.16 Very High Very High Very High
Serotonin 13 95.84 Very High Very High Very High
medulla 7 95.32 Very High Very High Very High
beta blocker 2 95.24 Very High Very High Very High
lidocaine 24 95.00 High High
antidepressant 2 94.64 High High
Disease Link Frequency Relevance Heat
Depression 192 100.00 Very High Very High Very High
Epilepsy 55 100.00 Very High Very High Very High
Cat Scratch Fever 19 100.00 Very High Very High Very High
Headache 115 99.36 Very High Very High Very High
Injury 9 97.48 Very High Very High Very High
Increased Venous Pressure Under Development 8 96.12 Very High Very High Very High
Migraine Disorders 105 95.24 Very High Very High Very High
Disease 8 95.24 Very High Very High Very High
Nociception 6 91.88 High High
Infarction 3 90.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CSD was induced by KCl injection and by modulating T-type Ca(2+) currents in incubated human neocortical tissues in an interphase mode.
Positive_regulation (induced) of CSD associated with depression
1) Confidence 0.59 Published 2001 Journal Brain Res. Section Abstract Doc Link 11430863 Disease Relevance 1.38 Pain Relevance 0.56
However, recent data show that migraine prophylactic agents may act by increasing the CSD threshold [55].
Positive_regulation (increasing) of CSD associated with depression and migraine
2) Confidence 0.48 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1609120 Disease Relevance 0.76 Pain Relevance 1.01
In this study we used mechanical stimulation to induce oligemia and hyperemia, in surgically prepared cats and rats, using laser Doppler probes to measure the cerebral blood flow and single cell cortical recording to measure the spike/neuronal burst, both generated as a consequence of CSD.
Positive_regulation (consequence) of CSD in neuronal associated with depression and increased venous pressure under development
3) Confidence 0.44 Published 2008 Journal Brain Res. Section Abstract Doc Link 18656463 Disease Relevance 0.98 Pain Relevance 0.57
In this study, CSD was elicited in alpha-chloralose anesthetized cats by cortical needle stab injury and monitored by means of laser Doppler flowmetry.
Positive_regulation (elicited) of CSD associated with depression and injury
4) Confidence 0.41 Published 1999 Journal Cephalalgia Section Abstract Doc Link 10448547 Disease Relevance 1.19 Pain Relevance 0.79
The results demonstrate that modulation of the Ca(2+) dynamics conditioned human neocortical slices and increased their susceptibility to generate CSD.
Positive_regulation (generate) of CSD associated with depression
5) Confidence 0.39 Published 2001 Journal Brain Res. Section Abstract Doc Link 11430863 Disease Relevance 1.13 Pain Relevance 0.58
Local injection of KCl triggered single CSD that propagated at 3.1+/-0.1 mm/min.
Positive_regulation (triggered) of CSD associated with depression
6) Confidence 0.39 Published 2001 Journal Brain Res. Section Abstract Doc Link 11430863 Disease Relevance 1.38 Pain Relevance 0.60
In this study we used mechanical stimulation to induce oligemia and hyperemia, in surgically prepared cats and rats, using laser Doppler probes to measure the cerebral blood flow and single cell cortical recording to measure the spike/neuronal burst, both generated as a consequence of CSD.
Positive_regulation (consequence) of CSD in spike associated with depression and increased venous pressure under development
7) Confidence 0.15 Published 2008 Journal Brain Res. Section Abstract Doc Link 18656463 Disease Relevance 0.98 Pain Relevance 0.57
CSD was induced by applying 3 mg of potassium chloride on parietal cortex.
Positive_regulation (induced) of CSD in parietal cortex
8) Confidence 0.14 Published 2006 Journal Headache Section Body Doc Link 16412149 Disease Relevance 0.36 Pain Relevance 0
While the specific factors that permit dissemination of CSD are not known, clinical experience confirms that the host response to B. henselae contributes to the manifestation of disease.
Positive_regulation (dissemination) of CSD associated with cat scratch fever and disease
9) Confidence 0.10 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC1810538 Disease Relevance 1.43 Pain Relevance 0
CSD was induced by cathodal electrical stimulation in the region under study by microdialysis.
Positive_regulation (induced) of CSD associated with depression
10) Confidence 0.05 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15041479 Disease Relevance 0.93 Pain Relevance 0.50
CSD as a generator of visual aura has also been supported with transcranial magnetic stimulation (Aurora 1998).
Positive_regulation (supported) of CSD associated with epilepsy, depression and transcranial magnetic stimulation
11) Confidence 0.05 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2386351 Disease Relevance 1.35 Pain Relevance 0.90
The biophysical mechanism of the extensive redistribution of ions causing CSD is incompletely understood.
Positive_regulation (causing) of CSD associated with depression
12) Confidence 0.05 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2137934 Disease Relevance 0.50 Pain Relevance 0.21
In each group, CSD was elicited in the right hemisphere in approximately half the animals and in the left hemisphere in the other rats.
Positive_regulation (elicited) of CSD associated with depression
13) Confidence 0.02 Published 2010 Journal PLoS Biology Section Body Doc Link PMC3006351 Disease Relevance 0.47 Pain Relevance 0.33
Two hours later CSD was elicited in the opposite side to the Day 1 training and memory was assessed by the reversal test.
Positive_regulation (elicited) of CSD associated with depression
14) Confidence 0.02 Published 2010 Journal PLoS Biology Section Body Doc Link PMC3006351 Disease Relevance 0.32 Pain Relevance 0.90
Another group was also forced to swim, but CSD was induced in the trained hemispheres (opposite side as on Day 1) to prevent memory from activating during the swim (Lat-Sw-CSD).
Positive_regulation (induced) of CSD associated with depression
15) Confidence 0.02 Published 2010 Journal PLoS Biology Section Body Doc Link PMC3006351 Disease Relevance 0.51 Pain Relevance 0.26
Two hours after the swim, CSD was elicited in the trained hemisphere of all animals and they were tested for IHT by reversal training.
Positive_regulation (elicited) of CSD associated with depression
16) Confidence 0.02 Published 2010 Journal PLoS Biology Section Body Doc Link PMC3006351 Disease Relevance 0.58 Pain Relevance 0.29

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