INT8361

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Context Info
Confidence 0.46
First Reported 1984
Last Reported 2008
Negated 2
Speculated 0
Reported most in Abstract
Documents 9
Total Number 12
Disease Relevance 0.54
Pain Relevance 3.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nts)
Anatomy Link Frequency
vagal nerve 4
ileum 2
brainstem 2
small intestine 2
nerve 1
Nts (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 340 100.00 Very High Very High Very High
addiction 28 100.00 Very High Very High Very High
agonist 17 100.00 Very High Very High Very High
Glutamate receptor 12 100.00 Very High Very High Very High
substance P 11 100.00 Very High Very High Very High
Neuropeptide 5 100.00 Very High Very High Very High
medulla 72 99.84 Very High Very High Very High
excitatory amino acid 44 99.20 Very High Very High Very High
antagonist 48 98.46 Very High Very High Very High
GABA receptor 4 97.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apnoea 36 95.24 Very High Very High Very High
Dyspnea 20 94.20 High High
Increased Venous Pressure Under Development 1 46.64 Quite Low
Cv Unclassified Under Development 4 11.12 Low Low
Hypoxia 8 5.00 Very Low Very Low Very Low
Hypercapnia 8 5.00 Very Low Very Low Very Low
Overdose 4 5.00 Very Low Very Low Very Low
Stroke 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in this study we found that application of P2 receptor antagonist PPADS in a high concentration on the dorsal surface of the brainstem had no effect on the amplitude of rhythmic glutamate release in the NTS.
Neg (no) Regulation (effect) of Localization (release) of NTS in brainstem associated with medulla, glutamate and antagonist
1) Confidence 0.46 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538935 Disease Relevance 0 Pain Relevance 0.36
Cooperative effects of bombesin, substance P and methacholine on the release of intestinal neurotensin in rats.
Regulation (effects) of Localization (release) of neurotensin associated with substance p
2) Confidence 0.37 Published 1992 Journal Regul. Pept. Section Title Doc Link 1371613 Disease Relevance 0 Pain Relevance 0.45
Rhythmic glutamate release in the NTS: dependence upon vagal nerve afferent input
Regulation (dependence) of Localization (release) of NTS in vagal nerve associated with addiction and glutamate
3) Confidence 0.34 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538935 Disease Relevance 0 Pain Relevance 0.60
Rhythmic ATP release in the NTS is not affected by the blockade of EAA receptors or activation of GABA receptors
Neg (not) Regulation (affected) of Localization (release) of NTS associated with gaba receptor and excitatory amino acid
4) Confidence 0.34 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538935 Disease Relevance 0.13 Pain Relevance 0.49
Rhythmic ATP release in the NTS is dependent upon vagal nerve afferent input
Regulation (dependent) of Localization (release) of NTS in vagal nerve
5) Confidence 0.34 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538935 Disease Relevance 0.42 Pain Relevance 0.15
The hypothesis of synergistic effects between luminal stimulants and the intramural neural network in the control of intestinal neurotensin (NT) release was investigated with an isolated vascularly perfused rat jejuno-ileum.
Regulation (control) of Localization (release) of neurotensin in ileum
6) Confidence 0.33 Published 1991 Journal Endocrinology Section Abstract Doc Link 1709858 Disease Relevance 0 Pain Relevance 0
Nervous control of the release of neurotensin-like immunoreactivity from the small intestine of the rat.
Regulation (control) of Localization (release) of neurotensin in small intestine associated with neuropeptide
7) Confidence 0.27 Published 1984 Journal Acta Physiol. Scand. Section Title Doc Link 6095596 Disease Relevance 0 Pain Relevance 0.44
A recently developed primary cell-culture system allows direct study of the cellular mechanisms regulating neurotensin secretion from intestinal mucosal cells.
Regulation (regulating) of Localization (secretion) of neurotensin
8) Confidence 0.27 Published 1986 Journal Am. J. Physiol. Section Abstract Doc Link 2869696 Disease Relevance 0 Pain Relevance 0
We now report the use of these methods to evaluate the modulation of neurotensin release by adrenergic, cholinergic, and peptidergic transmitters.
Regulation (modulation) of Localization (release) of neurotensin
9) Confidence 0.27 Published 1986 Journal Am. J. Physiol. Section Abstract Doc Link 2869696 Disease Relevance 0 Pain Relevance 0.08
The effects of glutamate receptor agonists on neurotensin release using in vivo microdialysis.
Regulation (effects) of Localization (release) of neurotensin associated with glutamate receptor and agonist
10) Confidence 0.23 Published 2001 Journal Eur. J. Pharmacol. Section Title Doc Link 11137867 Disease Relevance 0 Pain Relevance 0.43
Extracellular recording in guinea-pig or mouse vas deferens or rat tail artery was used to study the effects of some pharmacological agents on the nerve terminal spike (NTS) and the secretion of a sympathetic co-transmitter (presumably ATP), as reflected in the excitatory junction current (EJC).
Regulation (effects) of in nerve Localization (secretion) of NTS in vas deferens
11) Confidence 0.23 Published 1989 Journal Acta Physiol. Scand. Section Abstract Doc Link 2564719 Disease Relevance 0 Pain Relevance 0.21
Regulation of neurotensin release from canine enteric primary cell cultures.
Regulation (Regulation) of Localization (release) of neurotensin associated with neuropeptide
12) Confidence 0.12 Published 1986 Journal Am. J. Physiol. Section Title Doc Link 2869696 Disease Relevance 0 Pain Relevance 0.18

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