INT83616

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Context Info
Confidence 0.09
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 5.80
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6, IL8) extracellular region (IL6, IL8) signal transduction (IL8)
aging (IL6) intracellular (IL8)
IL6 (Homo sapiens)
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 54 100.00 Very High Very High Very High
Inflammation 38 100.00 Very High Very High Very High
Inflammatory response 6 92.24 High High
Analgesic 3 75.00 Quite High
cINOD 2 75.00 Quite High
Inflammatory mediators 1 64.04 Quite High
chemokine 55 50.00 Quite Low
cOX1 2 25.00 Low Low
COX2 2 25.00 Low Low
cerebral cortex 1 21.60 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 44 100.00 Very High Very High Very High
Delirium 13 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 35 98.96 Very High Very High Very High
Adhesions 5 98.96 Very High Very High Very High
Food Hypersensitivity 12 97.22 Very High Very High Very High
Sepsis 34 95.52 Very High Very High Very High
Syndrome 7 90.88 High High
Hypersensitivity 21 89.72 High High
Metabolic Disorder 8 87.08 High High
Anaphylaxis 4 77.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: To investigate anti-inflammatory effects of lornoxicam in vitro on COX-1/COX-2, on NO formation from iNOS and on the formation of the pro-inflammatory cytokines TNF-alpha, IL-1beta, IL-6, and IL-8.
IL-6 Binding (formation) of IL-8 associated with inflammation and cytokine
1) Confidence 0.09 Published 1999 Journal Inflamm. Res. Section Abstract Doc Link 10450786 Disease Relevance 0.20 Pain Relevance 0.30
OBJECTIVE: To investigate anti-inflammatory effects of lornoxicam in vitro on COX-1/COX-2, on NO formation from iNOS and on the formation of the pro-inflammatory cytokines TNF-alpha, IL-1beta, IL-6, and IL-8.
IL-6 Binding (formation) of IL-8 associated with inflammation and cytokine
2) Confidence 0.09 Published 1999 Journal Inflamm. Res. Section Abstract Doc Link 10450786 Disease Relevance 0.20 Pain Relevance 0.30
The authors performed a prospective study using a cohort of 59 patients with SLE and compared those with and without ACS as well as associations between ACS and each CSF test [IL-6, IL-8, IFN-?
IL-6 Binding (associations) of IL-8 associated with delirium and systemic lupus erythematosus
3) Confidence 0.05 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 1.76 Pain Relevance 0.05
B activation, which was associated with decreased levels of IL-8 but not of IL-6 or soluble intercellular adhesion molecule-1.
IL-6 Binding (associated) of IL-8 associated with adhesions
4) Confidence 0.05 Published 2004 Journal Crit Care Section Body Doc Link PMC522835 Disease Relevance 0.96 Pain Relevance 0.25
The induction of IP by tacrolimus leads to more food allergies.11,48 Exposure of intestinal CaCO2 cells to methylglyoxal or glyoxal, two potent glycating metabolites, in vitro is followed by increased IL-6 and IL-8 formation, which amplify the effects of TNF-?
IL-6 Binding (formation) of IL-8 associated with food hypersensitivity
5) Confidence 0.00 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898551 Disease Relevance 1.34 Pain Relevance 0.11
The induction of IP by tacrolimus leads to more food allergies.11,48 Exposure of intestinal CaCO2 cells to methylglyoxal or glyoxal, two potent glycating metabolites, in vitro is followed by increased IL-6 and IL-8 formation, which amplify the effects of TNF-?
IL-6 Binding (formation) of IL-8 associated with food hypersensitivity
6) Confidence 0.00 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898551 Disease Relevance 1.34 Pain Relevance 0.11

General Comments

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