INT83622

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Context Info
Confidence 0.49
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 3.77
Pain Relevance 2.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd59) plasma membrane (Cd59)
Anatomy Link Frequency
nerve 2
Schwann cells 2
Cd59 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuritis 18 99.90 Very High Very High Very High
Kinase C 8 99.80 Very High Very High Very High
Demyelination 8 99.00 Very High Very High Very High
cytokine 11 98.04 Very High Very High Very High
Inflammation 22 95.84 Very High Very High Very High
Spinal cord 114 50.00 Quite Low
Central nervous system 58 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 18 99.90 Very High Very High Very High
Cancer 7 99.84 Very High Very High Very High
Demyelinating Disease 8 99.00 Very High Very High Very High
Lifespan 2 96.40 Very High Very High Very High
INFLAMMATION 22 95.84 Very High Very High Very High
Necrosis 5 95.84 Very High Very High Very High
Syndrome 3 90.48 High High
Injury 114 47.68 Quite Low
Spinal Cord Injury 140 6.40 Low Low
Central Nervous System Disease 56 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased expression of CD59 in EAN is likely to be important in the protection of Schwann cells from MAC.
Positive_regulation (increased) of Gene_expression (expression) of CD59 in Schwann cells associated with neuritis
1) Confidence 0.49 Published 1999 Journal J. Neurol. Sci. Section Abstract Doc Link 10450801 Disease Relevance 1.04 Pain Relevance 0.68
The increased CD59 expression in EAN could therefore be due to the release of cytokines or other immunoregulatory molecules from the inflammatory cells.
Positive_regulation (increased) of Gene_expression (expression) of CD59 associated with inflammation, neuritis and cytokine
2) Confidence 0.49 Published 1999 Journal J. Neurol. Sci. Section Abstract Doc Link 10450801 Disease Relevance 1.10 Pain Relevance 0.72
In EAN the expression of CD59 was increased on Schwann cells during demyelination and axonal degeneration, evaluated by immunostaining of nerve sections and teased fibres.
Positive_regulation (increased) of Gene_expression (expression) of CD59 in nerve associated with demyelination and neuritis
3) Confidence 0.49 Published 1999 Journal J. Neurol. Sci. Section Abstract Doc Link 10450801 Disease Relevance 1.06 Pain Relevance 0.70
The contrasting PMA-induced CD59 expression in PMNs and cancer cells suggests different responses by these cell types to PMA stimulation.
Positive_regulation (-) of Gene_expression (expression) of CD59 associated with cancer
4) Confidence 0.39 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.29 Pain Relevance 0.12
However, previous studies have shown that PMA and PKC activity enhanced CD59 expression in cancer cells and therefore, increased the survival of these cells [30,31].
Positive_regulation (enhanced) of Gene_expression (expression) of CD59 associated with kinase c and cancer
5) Confidence 0.28 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.29 Pain Relevance 0.13

General Comments

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