INT83623

Context Info Confidence 0.76 First Reported 1999 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 7 Total Number 11 Disease Relevance 7.35 Pain Relevance 4.70

extracellular space (Cd59) plasma membrane (Cd59)

Anatomy Link Frequency Schwann cells 3 nerve 1 Cd59 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Neuritis 36 99.90 Kinase C 20 99.62 Demyelination 17 98.44 cytokine 26 98.04 Inflammation 52 96.84 Spinal cord 285 50.00 isoflurane 5 44.04 Central nervous system 145 25.96 ketamine 5 11.44 imagery 15 5.00

Disease Link Frequency Relevance Heat Experimental Autoimmune Neuritis 36 99.90 Cancer 16 99.84 Necrosis 11 99.04 Demyelinating Disease 17 98.44 Syndrome 6 97.92 Lifespan 5 97.84 INFLAMMATION 52 96.84 Injury 285 47.68 Spinal Cord Injury 350 34.68 Central Nervous System Disease 140 25.96

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Mutation

Event

Anatomy

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Speculation

Pain term

Disease term

The expression of CD59 in experimental allergic neuritis.

Gene_expression (expression) of CD59 associated with experimental autoimmune neuritis and neuritis

1) Confidence 0.76 Published 1999 Journal J. Neurol. Sci. Section Title Doc Link 10450801 Disease Relevance 1.08 Pain Relevance 0.71

However, interferon gamma (IFN-gamma) or tumor necrosis factor alfa (TNF-alpha) did not upregulate the expression of CD59 on rat Schwann cells in culture.

Gene_expression (expression) of CD59 in Schwann cells associated with necrosis and cancer

2) Confidence 0.66 Published 1999 Journal J. Neurol. Sci. Section Abstract Doc Link 10450801 Disease Relevance 1.06 Pain Relevance 0.69

The increased CD59 expression in EAN could therefore be due to the release of cytokines or other immunoregulatory molecules from the inflammatory cells.

Gene_expression (expression) of CD59 associated with inflammation, neuritis and cytokine

3) Confidence 0.66 Published 1999 Journal J. Neurol. Sci. Section Abstract Doc Link 10450801 Disease Relevance 1.09 Pain Relevance 0.72

In EAN the expression of CD59 was increased on Schwann cells during demyelination and axonal degeneration, evaluated by immunostaining of nerve sections and teased fibres.

Gene_expression (expression) of CD59 in nerve associated with demyelination and neuritis

4) Confidence 0.66 Published 1999 Journal J. Neurol. Sci. Section Abstract Doc Link 10450801 Disease Relevance 1.05 Pain Relevance 0.70

CD59, a potent complement regulatory protein that inhibits the formation of the terminal cytolytic membrane attack complex (MAC), is expressed on human and rat Schwann cells.

Gene_expression (expressed) of CD59 in Schwann cells

5) Confidence 0.66 Published 1999 Journal J. Neurol. Sci. Section Abstract Doc Link 10450801 Disease Relevance 1.01 Pain Relevance 0.65

The increased expression of CD59 in EAN is likely to be important in the protection of Schwann cells from MAC.

Gene_expression (expression) of CD59 in Schwann cells associated with neuritis

6) Confidence 0.66 Published 1999 Journal J. Neurol. Sci. Section Abstract Doc Link 10450801 Disease Relevance 1.04 Pain Relevance 0.67

Expression of C1q, C3, C4, C5, C6, C7, C9, CD59, Crry, and GADPH mRNAs in cultured PMNs was assayed by rt-PCR.

Gene_expression (Expression) of CD59

7) Confidence 0.43 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0 Pain Relevance 0

As discussed above for C3, mRNA expression of these complement inhibitors by PMNs was also decreased by PMA activation, suggesting that PKC activity enhancement in response to PMA stimulation inhibits PMN expression of CD59 and Crry, and therefore, may contribute to the short lifespan of several days for PMNs.

Gene_expression (expression) of CD59 associated with kinase c and lifespan

8) Confidence 0.43 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.26 Pain Relevance 0.13

However, previous studies have shown that PMA and PKC activity enhanced CD59 expression in cancer cells and therefore, increased the survival of these cells [30,31].

Gene_expression (expression) of CD59 associated with kinase c and cancer

9) Confidence 0.43 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.29 Pain Relevance 0.13

The contrasting PMA-induced CD59 expression in PMNs and cancer cells suggests different responses by these cell types to PMA stimulation.

Gene_expression (expression) of CD59 associated with cancer

10) Confidence 0.43 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.29 Pain Relevance 0.12

Besides the early complement mRNAs, cultured PMNs also expressed mRNAs encoding for CD59 and Crry, which are inhibitors of complement-mediated lysis.

Gene_expression (expressed) of CD59

11) Confidence 0.38 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.19 Pain Relevance 0.18

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