INT83640

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Context Info
Confidence 0.46
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0.12
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CD63) plasma membrane (CD63)
Anatomy Link Frequency
basophils 6
CD63 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 34 61.20 Quite High
cINOD 1 50.00 Quite Low
aspirin 6 10.00 Low Low
agonist 14 7.44 Low Low
Inflammation 12 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 32 62.72 Quite High
INFLAMMATION 13 50.00 Quite Low
Anaphylaxis 4 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Disease Susceptibility 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Chronic Disease 2 5.00 Very Low Very Low Very Low
Leukemia 2 5.00 Very Low Very Low Very Low
Adverse Drug Reaction 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: At present, basophil activation using CD63 and CD203c does not seem to be optimally sensitive for the diagnosis of ASA sensitivity.


Positive_regulation (activation) of Gene_expression (using) of CD63 in basophil
1) Confidence 0.46 Published 2009 Journal Int. Arch. Allergy Immunol. Section Body Doc Link 19494523 Disease Relevance 0 Pain Relevance 0
Quercetin showed also a marked ability to decrease in a dose-dependent fashion the expression of CD63 in basophils activated with the calcium ionophore A23187 (Figure 2, panels A,B).
Positive_regulation (activated) of Gene_expression (expression) of CD63 in basophils
2) Confidence 0.42 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2949734 Disease Relevance 0 Pain Relevance 0.03
M and appeared more pronounced for CD63 expression than for CD203c one (Figure 1 panel F).


Positive_regulation (pronounced) of Gene_expression (expression) of CD63
3) Confidence 0.42 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2949734 Disease Relevance 0 Pain Relevance 0
Increased expression of CD63 was observed most frequently and it was stronger than the alteration of the 2 other markers.
Positive_regulation (Increased) of Gene_expression (expression) of CD63
4) Confidence 0.18 Published 1999 Journal J. Allergy Clin. Immunol. Section Body Doc Link 10452764 Disease Relevance 0.06 Pain Relevance 0
After reaction of the basophils of the MR-allergic patients with MRs, increased surface expression of CD63 and CD45 and decreased expression of IgE were detected.
Positive_regulation (increased) of Gene_expression (expression) of CD63 in basophils
5) Confidence 0.18 Published 1999 Journal J. Allergy Clin. Immunol. Section Body Doc Link 10452764 Disease Relevance 0.06 Pain Relevance 0

General Comments

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