INT83641

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Context Info
Confidence 0.19
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.00
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CD63) plasma membrane (CD63)
Anatomy Link Frequency
Lymphocyte 1
basophils 1
CD63 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 1 92.00 High High
antagonist 2 91.16 High High
agonist 2 86.20 High High
withdrawal 2 85.28 High High
tolerance 2 78.96 Quite High
rheumatoid arthritis 5 66.20 Quite High
abatacept 1 65.20 Quite High
corticosteroid 2 62.40 Quite High
Arthritis 3 50.56 Quite High
Central nervous system 2 48.72 Quite Low
Disease Link Frequency Relevance Heat
Progressive Multifocal Leukoencephalopathy 1 97.36 Very High Very High Very High
Systemic Lupus Erythematosus 56 94.88 High High
Hypersensitivity 2 86.92 High High
Nephritis 6 79.88 Quite High
Cytomegalovirus Infection 1 74.20 Quite High
Rheumatoid Arthritis 5 66.20 Quite High
Hemolytic Anemia 1 53.44 Quite High
Thrombocytopenia 1 52.00 Quite High
Arthritis 3 50.56 Quite High
Motor Neuron Diseases 62 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results established that the cationic center and the hydrophobic group found in JN430 and MLA are important for the interaction with the AChRs.
MLA Binding (interaction) of
1) Confidence 0.19 Published 2010 Journal Biochemistry Section Abstract Doc Link 20377277 Disease Relevance 0 Pain Relevance 0.21
-CD63 (in-house), a marker of late-endosomes and lysosomes, and either rabbit or mouse ?
CD63 Binding (rabbit) of
2) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0.07 Pain Relevance 0.04
METHODS: For this assay, which we have named the BASIC assay, basophils are incubated in vitro with MR, after which they are fixed and then triple labeled with fluorescein-conjugated anti-CD63, tandem dye R-phycoerythrin-cyanin 5.1 conjugated anti-CD45, and R-phycoerythrin conjugated anti-IgE.
CD63 Binding (labeled) of in basophils
3) Confidence 0.10 Published 1999 Journal J. Allergy Clin. Immunol. Section Body Doc Link 10452764 Disease Relevance 0.09 Pain Relevance 0
Efalizumab, an LFA-1 inhibitor (Lymphocyte function associated Antigen-1), was withdrawn from the market in 2010 because of concerns with progressive multifocal leukoencephalopathy, and its cutaneous SLE trial was suspended.
Antigen-1 Binding (associated) of in Lymphocyte associated with progressive multifocal leukoencephalopathy and systemic lupus erythematosus
4) Confidence 0.02 Published 2010 Journal BMC Med Section Body Doc Link PMC3009611 Disease Relevance 0.84 Pain Relevance 0.19

General Comments

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