INT83642

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Context Info
Confidence 0.77
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 29
Disease Relevance 10.06
Pain Relevance 2.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CD63) plasma membrane (CD63)
Anatomy Link Frequency
basophils 7
platelet 3
Leukocyte 2
sputum 1
CD63 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 5 99.04 Very High Very High Very High
Angina 16 98.92 Very High Very High Very High
cytokine 74 95.76 Very High Very High Very High
Restless leg syndrome 6 95.76 Very High Very High Very High
Inflammation 177 95.36 Very High Very High Very High
backache 6 93.12 High High
Multiple sclerosis 6 93.00 High High
Kinase C 141 89.84 High High
psoriasis 35 88.56 High High
Arthritis 105 82.80 Quite High
Disease Link Frequency Relevance Heat
Adhesions 84 100.00 Very High Very High Very High
Cv General 3 Under Development 18 98.92 Very High Very High Very High
INFLAMMATION 223 98.84 Very High Very High Very High
Nicotine Addiction 222 97.92 Very High Very High Very High
Hypersensitivity 122 97.38 Very High Very High Very High
Infection 12 96.40 Very High Very High Very High
Peripheral Arterial Disease 9 96.16 Very High Very High Very High
Increased Venous Pressure Under Development 13 95.76 Very High Very High Very High
Disease Progression 5 94.16 High High
Vomiting 2 94.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For the diagnosis of allergy, cellular basophil activation tests (BAT), e.g. histamine or sulfidoleukotriene release tests, have long been introduced, but the expression of basophil activation markers such as CD63 and CD203c detected by flow cytometry has attracted more recent attention.
Gene_expression (expression) of CD63 in basophil associated with hypersensitivity
1) Confidence 0.77 Published 2008 Journal Int. Arch. Allergy Immunol. Section Abstract Doc Link 18268385 Disease Relevance 0.21 Pain Relevance 0.05
Quercetin showed also a marked ability to decrease in a dose-dependent fashion the expression of CD63 in basophils activated with the calcium ionophore A23187 (Figure 2, panels A,B).
Gene_expression (expression) of CD63 in basophils
2) Confidence 0.65 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2949734 Disease Relevance 0 Pain Relevance 0.03
In response to calcium ionophore A23187 the expression of both the activation markers CD63 and CD203c was markedly up-regulated, but quercetin exerted a significant inhibitory action, even at nanomolar doses, only on CD63, so dissecting the response of the two activation markers to the ionophore.
Gene_expression (expression) of CD63
3) Confidence 0.65 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2949734 Disease Relevance 0 Pain Relevance 0.23
CONCLUSION: At present, basophil activation using CD63 and CD203c does not seem to be optimally sensitive for the diagnosis of ASA sensitivity.


Gene_expression (using) of CD63 in basophil
4) Confidence 0.61 Published 2009 Journal Int. Arch. Allergy Immunol. Section Body Doc Link 19494523 Disease Relevance 0 Pain Relevance 0
M and appeared more pronounced for CD63 expression than for CD203c one (Figure 1 panel F).


Gene_expression (expression) of CD63
5) Confidence 0.56 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2949734 Disease Relevance 0 Pain Relevance 0
In basophils stimulated with anti-human IgE, quercetin was able to inhibit in a dose-dependent fashion both the tetraspan (Figure 1, panels A,B) and the ectoenzyme up-regulation (Figure 1 panel C); quercetin IC50 able to inhibit CD63 expression was about 0.132 ?
Gene_expression (expression) of CD63 in basophils
6) Confidence 0.50 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2949734 Disease Relevance 0 Pain Relevance 0
Quercetin inhibited the expression of CD63 and CD203c and the histamine release in basophils activated with anti-IgE or with the ionophore: the IC50 in the anti-IgE model was higher than in the ionophore model and the effects were more pronounced for CD63 than for CD203c.
Gene_expression (expression) of CD63 in basophils
7) Confidence 0.50 Published 2010 Journal Clin Mol Allergy Section Abstract Doc Link PMC2949734 Disease Relevance 0.13 Pain Relevance 0.03
Figure 1 shows the dose response of the flavonoid quercetin on the expression of human basophil activation markers CD63 and CD203c following stimulation with 4 ?
Gene_expression (expression) of CD63 in basophil
8) Confidence 0.50 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2949734 Disease Relevance 0 Pain Relevance 0
Figure 2(A-B) illustrates the temporal pattern of cell surface CD66b and CD63 degranulation marker expression on PMNs.
Gene_expression (expression) of CD63
9) Confidence 0.46 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.11 Pain Relevance 0
Neither resuscitation strategy was found to influence PMN expression of CD63-positive azurophilic granules, since the surface density did not differ between patients and healthy controls at any time-point.


Gene_expression (expression) of CD63
10) Confidence 0.46 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.17 Pain Relevance 0
Percentage of activated cells was calculated by the software considering the CD63 expressing cells (CD63-FITCpositive cells) counted to the right of a threshold that was established including the main peak of fluorescence of a sample of resting cells.
Gene_expression (expressing) of CD63
11) Confidence 0.44 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2949734 Disease Relevance 0 Pain Relevance 0
Percentage of activated cells was calculated by the software considering the CD63 expressing cells (CD63-FITCpositive cells) counted to the right of a threshold that was established including the main peak of fluorescence of a sample of resting cells.
Gene_expression (expressing) of CD63
12) Confidence 0.44 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2949734 Disease Relevance 0 Pain Relevance 0
Patients exhibited higher PMPs, increased platelet %CD62P, %CD63 and soluble P selectin (all P < 0.01) and hs-CRP (P = 0.0167) than healthy controls.
Gene_expression (exhibited) of CD63 in platelet
13) Confidence 0.38 Published 2005 Journal Platelets Section Abstract Doc Link 16194867 Disease Relevance 0.96 Pain Relevance 0.20
Smoking had also no significant effect on the levels of inflammatory mediators in sputum (additional file 1, table 3) and the expression of CD11b, CD63 and HLA-DR on CD14 high and CD14 low cells and the number of iNOS positive macrophages (data not shown).


Gene_expression (expression) of CD63 in sputum associated with inflammatory mediators and nicotine addiction
14) Confidence 0.32 Published 2005 Journal Respir Res Section Body Doc Link PMC554761 Disease Relevance 1.40 Pain Relevance 0.08
There was no significant difference in the expression of CD11b, CD63 and HLA-DR on CD14 high and CD14 low cells between smoking and no smoking (data not shown).


Gene_expression (expression) of CD63 associated with nicotine addiction
15) Confidence 0.32 Published 2005 Journal Respir Res Section Body Doc Link PMC554761 Disease Relevance 1.27 Pain Relevance 0
CD63 is found abundantly in lysosomes, and its trafficking and cellular distribution is tightly regulated [62].
Gene_expression (found) of CD63
16) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0.08 Pain Relevance 0
The small vacuoles found in cells expressing WT CHMP2B co-localised with large areas of CD63 staining – displaying the normal physiological fusion of late endosomes with lysosomes (Figure 6 F–H).
Gene_expression (expressing) of CD63
17) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0.18 Pain Relevance 0
Increased expression of CD63 was observed most frequently and it was stronger than the alteration of the 2 other markers.
Gene_expression (expression) of CD63
18) Confidence 0.20 Published 1999 Journal J. Allergy Clin. Immunol. Section Body Doc Link 10452764 Disease Relevance 0.06 Pain Relevance 0
After reaction of the basophils of the MR-allergic patients with MRs, increased surface expression of CD63 and CD45 and decreased expression of IgE were detected.
Gene_expression (expression) of CD63 in basophils
19) Confidence 0.20 Published 1999 Journal J. Allergy Clin. Immunol. Section Body Doc Link 10452764 Disease Relevance 0.06 Pain Relevance 0
In contrast, cells expressing mutant CHMP2B often showed CD63 immunostaining on the membranes of large vacuoles (Figure 6 I–K).
Gene_expression (immunostaining) of CD63
20) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0.20 Pain Relevance 0

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