INT83646

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Context Info
Confidence 0.37
First Reported 1999
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 4.41
Pain Relevance 3.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1rn) extracellular region (Il1rn) nucleus (Il1rn)
lipid metabolic process (Il1rn) cytoplasm (Il1rn)
Anatomy Link Frequency
pituitary 2
blood 1
brain 1
Il1rn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 30 100.00 Very High Very High Very High
Intracerebroventricular 4 99.98 Very High Very High Very High
Dopamine 34 99.48 Very High Very High Very High
antidepressant 40 98.56 Very High Very High Very High
Inflammation 142 97.40 Very High Very High Very High
dexamethasone 5 91.28 High High
COX-2 inhibitor 5 90.96 High High
cytokine 59 89.84 High High
Substantia nigra 42 87.20 High High
depression 46 86.80 High High
Disease Link Frequency Relevance Heat
Death 8 99.92 Very High Very High Very High
Disease 85 99.76 Very High Very High Very High
Necrosis 10 99.00 Very High Very High Very High
Cancer 8 98.64 Very High Very High Very High
INFLAMMATION 159 97.40 Very High Very High Very High
Acute Coronary Syndrome 64 95.04 Very High Very High Very High
Stress 8 91.92 High High
Coronary Artery Disease 24 91.04 High High
Depression 50 86.80 High High
Osteoarthritis 20 83.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The IL-1Ra VNTR showed neither an association with paroxetine nor with mirtazapine treatment response.
IL-1Ra Neg (neither) Binding (association) of
1) Confidence 0.37 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Abstract Doc Link PMC2515903 Disease Relevance 0.16 Pain Relevance 0.31
Additionally, we did not find an association of the IL-1Ra (86bp)n intron 2 polymorphism with antidepressant response to paroxetine and mirtazapine.
IL-1Ra Neg (not) Binding (association) of associated with antidepressant
2) Confidence 0.37 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2515903 Disease Relevance 0.26 Pain Relevance 0.37
Intracerebroventricular injection of interleukin-1 receptor antagonist (IL-1ra) also inhibited the pituitary-adrenal response to laparotomy.
interleukin-1 receptor antagonist Binding (injection) of in pituitary associated with antagonist and intracerebroventricular
3) Confidence 0.32 Published 2000 Journal Neuroimmunomodulation Section Abstract Doc Link 10810250 Disease Relevance 0.23 Pain Relevance 0.34
Intracerebroventricular injection of interleukin-1 receptor antagonist (IL-1ra) also inhibited the pituitary-adrenal response to laparotomy.
IL-1ra Binding (injection) of in pituitary associated with antagonist and intracerebroventricular
4) Confidence 0.32 Published 2000 Journal Neuroimmunomodulation Section Abstract Doc Link 10810250 Disease Relevance 0.23 Pain Relevance 0.34
One week later, animals were randomized to receive TNF-binding protein (TNF-bp), IL-1 receptor antagonist (IL-1ra), or saline (NS) prior to standardized laparotomy.
IL-1ra Binding (receive) of associated with antagonist
5) Confidence 0.24 Published 1999 Journal J. Surg. Res. Section Abstract Doc Link 10452868 Disease Relevance 0.49 Pain Relevance 0.33
One week later, animals were randomized to receive TNF-binding protein (TNF-bp), IL-1 receptor antagonist (IL-1ra), or saline (NS) prior to standardized laparotomy.
IL-1 receptor antagonist Binding (receive) of associated with antagonist
6) Confidence 0.21 Published 1999 Journal J. Surg. Res. Section Abstract Doc Link 10452868 Disease Relevance 0.49 Pain Relevance 0.33
It should be emphasized however that associations of the IL-1RN-VNTR with disease may be related to either this protein or the interleukin gene cluster, in particular the IL1-beta gene, whose promoter variants are in disequilibrium with the VNTR [21,25].
IL-1RN-VNTR Binding (associations) of associated with disease
7) Confidence 0.18 Published 2004 Journal BMC Med Genet Section Body Doc Link PMC425582 Disease Relevance 0.78 Pain Relevance 0.29
Fig. 1a indicates that the white cell counts were not influenced by either the IL1RN or their IL6 genotypes.
IL1RN Binding (influenced) of
8) Confidence 0.12 Published 2004 Journal BMC Med Genet Section Body Doc Link PMC425582 Disease Relevance 0.46 Pain Relevance 0.18
and interleukin 1 (IL1) release from human blood buffy coat cells than the inhibition seen with each of the single agents alone.20 Similarly, in the rat model of lipopolysaccharide (LPS)-induced TNF?
IL1 Binding (interleukin 1) of in blood
9) Confidence 0.04 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564788 Disease Relevance 1.07 Pain Relevance 0.53
CONCLUSION: Our data establish a highly significant disease association with markers in the IL1RN gene.
IL1RN gene Binding (association) of
10) Confidence 0.03 Published 2003 Journal Arthritis Rheum. Section Body Doc Link 12847695 Disease Relevance 0 Pain Relevance 0
Association with specific haplotypes raises the possibility that the primary disease locus is in linkage disequilibrium with a specific combination(s) of markers in the IL1RN gene.


IL1RN gene Binding (Association) of
11) Confidence 0.03 Published 2003 Journal Arthritis Rheum. Section Body Doc Link 12847695 Disease Relevance 0 Pain Relevance 0
IL-1ra administered in the periphery has previously been shown to cross the blood brain barrier [36,37].
IL-1ra Binding (cross) of in brain
12) Confidence 0.02 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2292163 Disease Relevance 0.24 Pain Relevance 0.47

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