INT83647

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Context Info
Confidence 0.28
First Reported 1999
Last Reported 2001
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.97
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs2) nuclear envelope (Ptgs2) oxidoreductase activity (Ptgs2)
endoplasmic reticulum (Ptgs2) nucleus (Ptgs2) enzyme binding (Ptgs2)
Anatomy Link Frequency
bowel 2
Ptgs2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 4 100.00 Very High Very High Very High
cytokine 2 100.00 Very High Very High Very High
central pain 1 96.60 Very High Very High Very High
excitatory amino acid 1 94.68 High High
Thermal hyperalgesia 2 91.28 High High
allodynia 2 90.40 High High
acular 1 90.32 High High
Lasting pain 1 89.12 High High
Spinal cord 5 85.92 High High
antagonist 1 77.68 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 100.00 Very High Very High Very High
Necrosis 1 100.00 Very High Very High Very High
Cancer 1 100.00 Very High Very High Very High
Pain 2 96.28 Very High Very High Very High
Syndrome 2 96.08 Very High Very High Very High
Injury 6 95.44 Very High Very High Very High
Ileus 1 94.48 High High
Hyperalgesia 2 91.28 High High
Neuropathic Pain 2 90.40 High High
Spinal Cord Injury 4 85.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesized that selective inhibition of cyclooxygenase-2 (COX-2), an inducible inflammatory mediator, would decrease tissue damage and subsequently reduce locomotor deficits and development of chronic central pain syndromes after injury.
Negative_regulation (decrease) of Negative_regulation (inhibition) of cyclooxygenase-2 associated with pain, central pain, inflammation, syndrome and injury
1) Confidence 0.28 Published 2001 Journal J. Neurotrauma Section Abstract Doc Link 11336442 Disease Relevance 1.41 Pain Relevance 0.70
We examined whether inhibition of the proinflammatory cytokines, tumor necrosis factor alpha (TNFalpha) and interleukin-1 (IL-1), or selective blockade of cyclooxygenase-2 (COX-2), the COX isoform induced during inflammation, would accelerate postoperative small bowel transit in our model.
Spec (whether) Negative_regulation (inhibition) of Spec (whether) Negative_regulation (blockade) of cyclooxygenase-2 in bowel associated with necrosis, inflammation, cancer and cytokine
2) Confidence 0.16 Published 1999 Journal J. Surg. Res. Section Abstract Doc Link 10452868 Disease Relevance 0.56 Pain Relevance 0.35

General Comments

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