INT83659

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Context Info
Confidence 0.37
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.57
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tnf) signal transduction (Tnf) extracellular space (Tnf)
extracellular region (Tnf) plasma membrane (Tnf) intracellular (Tnf)
Anatomy Link Frequency
nucleus 2
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1 100.00 Very High Very High Very High
Paracetamol 9 99.88 Very High Very High Very High
allodynia 2 98.80 Very High Very High Very High
Thermal hyperalgesia 1 97.80 Very High Very High Very High
adenocard 1 92.00 High High
Hyperalgesia 2 89.80 High High
Sciatic nerve 1 87.84 High High
Pain 2 83.80 Quite High
IPN 1 82.72 Quite High
neuralgia 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Necrosis 3 100.00 Very High Very High Very High
Cancer 1 100.00 Very High Very High Very High
Neuropathic Pain 3 98.80 Very High Very High Very High
Hyperalgesia 3 97.80 Very High Very High Very High
Death 3 88.80 High High
Injury 1 87.00 High High
Nervous System Injury 1 84.76 Quite High
Pain 2 83.80 Quite High
Inflammatory Pain 1 82.72 Quite High
Disease 1 81.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, Cardiospermum halicacabum L. ethanol extract inhibited the TNF-alpha induced DNA binding activity of NF-kappaB, which was associated with decreased p65 protein level in the nucleus in Jurkat cells.
Negative_regulation (inhibited) of TNF-alpha Binding (binding) of in nucleus
1) Confidence 0.37 Published 2009 Journal J Ethnopharmacol Section Body Doc Link 19393729 Disease Relevance 0.06 Pain Relevance 0
Furthermore, immunoreactivity for the proinflammatory cytokine tumor necrosis factor-alpha (TNF) was reduced in mice treated with the highest dose of anti-IL-1RI.
Negative_regulation (reduced) of tumor necrosis factor-alpha Binding (immunoreactivity) of associated with necrosis, cancer and cytokine
2) Confidence 0.37 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10454137 Disease Relevance 1.07 Pain Relevance 0.80
Treatment of mice with the protein before administration of acetaminophen also reduced serum nitrite and TNF-alpha formation.
Negative_regulation (reduced) of TNF-alpha Binding (formation) of associated with paracetamol
3) Confidence 0.27 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 18835260 Disease Relevance 0.44 Pain Relevance 0.63

General Comments

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