INT83674

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Context Info
Confidence 0.59
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 7.28
Pain Relevance 9.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SCN10A) transmembrane transport (SCN10A)
Anatomy Link Frequency
dorsal root ganglia 4
neurons 2
skin 2
SNS 2
outflow 1
SCN10A (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 20 100.00 Very High Very High Very High
Clonidine 6 99.92 Very High Very High Very High
sodium channel 72 99.90 Very High Very High Very High
dorsal root ganglion 14 99.60 Very High Very High Very High
Mexiletine 2 99.30 Very High Very High Very High
lidocaine 1 99.00 Very High Very High Very High
Hippocampus 16 97.78 Very High Very High Very High
Pain 44 97.72 Very High Very High Very High
agonist 6 97.60 Very High Very High Very High
guanethidine 3 95.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 14 99.60 Very High Very High Very High
Injury 18 99.40 Very High Very High Very High
Anxiety Disorder 8 98.80 Very High Very High Very High
Pain 30 97.72 Very High Very High Very High
Mycobacterium Infection 18 93.96 High High
Nociception 5 92.60 High High
Depression 112 91.04 High High
Hypersensitivity 4 90.56 High High
INFLAMMATION 13 90.00 High High
Stress 12 89.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In humans, the effects of SNS inhibition on subjective and physiologic sexual arousal were also examined using clonidine to suppress SNS activity.
Spec (examined) Negative_regulation (suppress) of SNS in SNS associated with clonidine
1) Confidence 0.59 Published 2000 Journal Am. J. Cardiol. Section Abstract Doc Link 10899275 Disease Relevance 0 Pain Relevance 0.32
Dramatic changes in sodium channel expression, including downregulation of the SNS/PN3 and NaN sodium channel genes and upregulation of previously silent type III sodium channel gene, occur in DRG neurons following axonal transection.
Negative_regulation (downregulation) of SNS in neurons associated with sodium channel
2) Confidence 0.57 Published 1999 Journal Muscle Nerve Section Abstract Doc Link 10454712 Disease Relevance 0.36 Pain Relevance 0.88
There is a dramatic change in sodium channel expression in DRG neurons, with down-regulation of the SNS/PN3 and NaN sodium channel genes and up-regulation of previously silent Type III sodium channel gene, following injury to the axons of these cells.
Negative_regulation (regulation) of SNS in DRG associated with dorsal root ganglion, injury and sodium channel
3) Confidence 0.57 Published 1999 Journal Pain Section Abstract Doc Link 10491982 Disease Relevance 1.10 Pain Relevance 1.12
In brachial plexus injury patients, there was an acute decrease of SNS/PN3- and NaN/SNS2-like immunoreactivity in sensory cell bodies of cervical dorsal root ganglia (DRG) whose central axons had been avulsed from spinal cord, with gradual return of the immunoreactivity to control levels over months.
Negative_regulation (decrease) of SNS/PN3 in dorsal root ganglia associated with injury and spinal cord
4) Confidence 0.51 Published 2000 Journal Pain Section Abstract Doc Link 10692601 Disease Relevance 0.47 Pain Relevance 0.53
Dramatic changes in sodium channel expression, including downregulation of the SNS/PN3 and NaN sodium channel genes and upregulation of previously silent type III sodium channel gene, occur in DRG neurons following axonal transection.
Negative_regulation (downregulation) of PN3 in neurons associated with sodium channel
5) Confidence 0.42 Published 1999 Journal Muscle Nerve Section Abstract Doc Link 10454712 Disease Relevance 0.36 Pain Relevance 0.88
There is a dramatic change in sodium channel expression in DRG neurons, with down-regulation of the SNS/PN3 and NaN sodium channel genes and up-regulation of previously silent Type III sodium channel gene, following injury to the axons of these cells.
Negative_regulation (regulation) of PN3 in DRG associated with dorsal root ganglion, injury and sodium channel
6) Confidence 0.42 Published 1999 Journal Pain Section Abstract Doc Link 10491982 Disease Relevance 1.11 Pain Relevance 1.12
We previously demonstrated that sodium channel SNS/PN3 alpha-subunits were decreased in human sensory cell bodies after spinal root avulsion injury, and accumulated at injured nerve terminals in pain states.
Negative_regulation (decreased) of PN3 in nerve associated with pain, injury and sodium channel
7) Confidence 0.42 Published 2001 Journal Neuroreport Section Abstract Doc Link 11234750 Disease Relevance 0.26 Pain Relevance 0.27
Selective SNS/PN3- and NaN/SNS2-blocking agents may provide new therapy for back pain and sciatica.


Negative_regulation (blocking) of SNS
8) Confidence 0.41 Published 2002 Journal Spine Section Body Doc Link 11805657 Disease Relevance 0 Pain Relevance 0
We conclude that decreased NGF- and SNS/PN3-immunoreactivity, and loss of intra-epidermal innervation, may be found without sensory loss on quantitative testing in clinically-unaffected skin in leprosy; this appears to be a sub-clinical change, and may explain the lack of cutaneous pain with inflammation.
Negative_regulation (decreased) of SNS in skin associated with pain, inflammation, nerve growth factor and mycobacterium infection
9) Confidence 0.41 Published 2000 Journal Pain Section Abstract Doc Link 10692623 Disease Relevance 1.02 Pain Relevance 0.94
Lidocaine and mexiletine exhibited tonic and use-dependent block of PN1 and PN3 channels.
Negative_regulation (block) of PN3 associated with mexiletine and lidocaine
10) Confidence 0.39 Published 2003 Journal Recept. Channels Section Abstract Doc Link 14527872 Disease Relevance 0.19 Pain Relevance 0.99
The effects of SNS inhibition on sexual responses in the female rat were examined in 3 studies using clonidine, an alpha(2)-adrenergic agonist; guanethidine, a postganglionic noradrenergic blocker; and naphazoline, an alpha(2)-adrenoreceptor agonist, to inhibit sympathetic outflow.
Negative_regulation (inhibition) of SNS in outflow associated with guanethidine, agonist and clonidine
11) Confidence 0.38 Published 2000 Journal Am. J. Cardiol. Section Abstract Doc Link 10899275 Disease Relevance 0 Pain Relevance 0.31
In humans, the effects of SNS inhibition on subjective and physiologic sexual arousal were also examined using clonidine to suppress SNS activity.
Negative_regulation (inhibition) of SNS in SNS associated with clonidine
12) Confidence 0.38 Published 2000 Journal Am. J. Cardiol. Section Abstract Doc Link 10899275 Disease Relevance 0 Pain Relevance 0.33
In brachial plexus injury patients, there was an acute decrease of SNS/PN3- and NaN/SNS2-like immunoreactivity in sensory cell bodies of cervical dorsal root ganglia (DRG) whose central axons had been avulsed from spinal cord, with gradual return of the immunoreactivity to control levels over months.
Negative_regulation (decrease) of SNS/PN3 in dorsal root ganglia associated with injury and spinal cord
13) Confidence 0.37 Published 2000 Journal Pain Section Abstract Doc Link 10692601 Disease Relevance 0.47 Pain Relevance 0.53
We conclude that decreased NGF- and SNS/PN3-immunoreactivity, and loss of intra-epidermal innervation, may be found without sensory loss on quantitative testing in clinically-unaffected skin in leprosy; this appears to be a sub-clinical change, and may explain the lack of cutaneous pain with inflammation.
Negative_regulation (decreased) of PN3 in skin associated with pain, inflammation, nerve growth factor and mycobacterium infection
14) Confidence 0.18 Published 2000 Journal Pain Section Abstract Doc Link 10692623 Disease Relevance 1.02 Pain Relevance 0.94
By contrast, the hippocampus has an inhibitory effect upon the hypothalamus [88], principally via the involvement of its ventral region in inhibition of the sympathetic nervous system (SNS) and subsequent reduction of anxiety behaviours [89].
Negative_regulation (inhibition) of SNS in hippocampus associated with anxiety disorder and hippocampus
15) Confidence 0.09 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC3009949 Disease Relevance 0.94 Pain Relevance 0.47

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