INT8368

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Context Info
Confidence 0.34
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 1.66
Pain Relevance 6.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
smooth muscle 1
spinal cord 1
ureter 1
diencephalon 1
spinal cord neurons 1
Nka1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 65 100.00 Very High Very High Very High
excitatory amino acid 2 100.00 Very High Very High Very High
Neuropeptide 31 99.72 Very High Very High Very High
primary afferent fibers 2 99.40 Very High Very High Very High
Spinal cord 6 98.32 Very High Very High Very High
Calcitonin gene-related peptide 10 98.18 Very High Very High Very High
Potency 5 98.16 Very High Very High Very High
qutenza 39 97.80 Very High Very High Very High
Glutamate 2 97.70 Very High Very High Very High
spinal dorsal horn 5 94.94 High High
Disease Link Frequency Relevance Heat
Hypotension 2 98.56 Very High Very High Very High
Right Ventricular Hypertrophy 5 97.32 Very High Very High Very High
Adhesions 1 97.12 Very High Very High Very High
Apoptosis 1 96.52 Very High Very High Very High
Hypertension 5 95.68 Very High Very High Very High
Headache 1 89.12 High High
Epilepsy 1 88.32 High High
Parkinson's Disease 1 87.28 High High
Nociception 1 87.04 High High
Immunization 4 86.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite pharmacological evidence that NKA preferentially binds NK-2 receptors, this receptor is not found in spinal cord neurons.
NKA Binding (binds) of in spinal cord neurons associated with spinal cord
1) Confidence 0.34 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11331395 Disease Relevance 0.09 Pain Relevance 0.56
Whole-cell patch-clamp technique of freshly isolated rat spinal dorsal horn (DH) neurons, intracellular recording from DH neurons in a slice preparation, and high performance liquid chromatography with fluorimetric detection of release of endogenous glutamate and aspartate from spinal cord slice following activation of primary afferent fibers were employed to investigate interactions between excitatory amino acids (EAA) and tachykinins [substance P (SP) and neurokinin A (NKA)].
NKA Binding (interactions) of in spinal cord associated with glutamate, primary afferent fibers, spinal dorsal horn, substance p, excitatory amino acid and spinal cord
2) Confidence 0.32 Published 1993 Journal Brain Res. Bull. Section Abstract Doc Link 7681351 Disease Relevance 0 Pain Relevance 0.79
Tachykinins, such as substance P (SP) and neurokinin A (NKA), may mediate these effects.
NKA Binding (mediate) of associated with substance p
3) Confidence 0.29 Published 2000 Journal Chin J Physiol Section Abstract Doc Link 11292182 Disease Relevance 0.56 Pain Relevance 0.54
The signal transduction function can be triggered by the binding of ouabain, the mammalian analogue of digitalis to NKA.
NKA Binding (binding) of
4) Confidence 0.24 Published 2007 Journal J. Intern. Med. Section Abstract Doc Link 17222167 Disease Relevance 0.46 Pain Relevance 0.09
At alpha-SP Ab dilutions of 1 in 5,000 to 1 in 32,000, CGRP did not prevent antibody binding to SP-BSA conjugate bound to the plates, but both SP and NKA prevented binding.
NKA Binding (binding) of associated with calcitonin gene-related peptide and substance p
5) Confidence 0.17 Published 1995 Journal Life Sci. Section Abstract Doc Link 7541500 Disease Relevance 0.37 Pain Relevance 1.01
NKA and NPK evoked much stronger bronchoconstrictor effects than SP, while SP was more active than NKA in inducing vascular permeability changes.
NKA Binding (evoked) of
6) Confidence 0.17 Published 1986 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 2430427 Disease Relevance 0.19 Pain Relevance 0.66
Both NKA and NPK initiated, as well as increased, the magnitude of the peristaltic contractions of the ureter, while SP only caused a minor excitatory effect.
NKA Binding (initiated) of in ureter associated with substance p
7) Confidence 0.06 Published 1986 Journal Acta Physiol. Scand. Section Abstract Doc Link 2431598 Disease Relevance 0 Pain Relevance 1.10
Cross-desensitization studies confirmed that SPME and SP interacted with NK-1 receptors, [beta-Ala8]NKA-(4-10) and NKA with NK-2 receptors, and senktide and NKB with NK-3 receptors.
NKA Binding (interacted) of associated with substance p
8) Confidence 0.05 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 7682782 Disease Relevance 0 Pain Relevance 0.38
In contrast, only binding sites to NKA could be observed over the smooth muscle.
NKA Binding (binding) of in smooth muscle
9) Confidence 0.05 Published 1993 Journal Neuropeptides Section Abstract Doc Link 7681552 Disease Relevance 0 Pain Relevance 0.19
Both NKA and SP relaxed the guinea pig pulmonary artery with similar potency.
NKA Binding (relaxed) of in pulmonary artery associated with potency
10) Confidence 0.05 Published 1988 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 2462373 Disease Relevance 0 Pain Relevance 0.44
In competitive binding studies with [3H]SP, the order of potency for the neurokinins was SP much greater than neurokinin A (NKA) greater than neurokinin B (NKB), suggesting that the high-affinity binding sites were NK-1 receptors. [125I]NKA is also bound to newborn tissue homogenate with high affinity.
NKA Binding (bound) of associated with potency and substance p
11) Confidence 0.04 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1371647 Disease Relevance 0 Pain Relevance 0.51
The different age dependent expression patterns seen in our data for NPK and NKA (NPK is unaffected by age whereas NKA is significantly upregulated) can also be interpreted as involvement in separate biological processes during diencephalon development.
NKA Binding (data) of in diencephalon
12) Confidence 0.03 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2851587 Disease Relevance 0 Pain Relevance 0.04

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