INT83682

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Context Info
Confidence 0.68
First Reported 1999
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 22
Total Number 22
Disease Relevance 3.30
Pain Relevance 15.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcb1a) ATPase activity (Abcb1a) plasma membrane (Abcb1a)
transmembrane transport (Abcb1a)
Anatomy Link Frequency
brain 3
Caco-2 2
liver 1
vessels 1
intestine 1
Abcb1a (Mus musculus)
Pain Link Frequency Relevance Heat
methadone 100 99.98 Very High Very High Very High
Morphine 30 99.98 Very High Very High Very High
Oxycodone 18 99.98 Very High Very High Very High
Cannabinoid 16 99.84 Very High Very High Very High
qutenza 33 99.58 Very High Very High Very High
Paracetamol 11 99.56 Very High Very High Very High
Antinociceptive 16 99.44 Very High Very High Very High
fortral 11 99.38 Very High Very High Very High
Abstinence syndrome 6 97.88 Very High Very High Very High
Buprenorphine 12 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 38 99.96 Very High Very High Very High
Skin Cancer 16 97.96 Very High Very High Very High
Newborn Drug Withdrawal Syndrome 6 97.88 Very High Very High Very High
Cancer 79 97.24 Very High Very High Very High
Breast Cancer 17 96.08 Very High Very High Very High
Osteogenic Sarcomas 11 93.88 High High
Plasmacytoma 2 93.20 High High
Opiate Addiction 8 92.96 High High
Pain 6 87.36 High High
Stress 14 83.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Methadone stimulated the P-gp ATPase activity only at higher concentrations, while verapamil and GF120918 inhibited its efflux (p < 0.05).
Positive_regulation (stimulated) of P-gp associated with methadone
1) Confidence 0.68 Published 2009 Journal J Pharm Sci Section Abstract Doc Link 19370547 Disease Relevance 0.18 Pain Relevance 1.38
The induction of P-gp protein and mRNA levels was also influenced by capsaicin concentration and duration of exposure, with higher expression levels, in particular of the mRNA, seen at higher spice concentrations over prolonged period of incubation.
Positive_regulation (induction) of P-gp protein associated with qutenza
2) Confidence 0.55 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16674925 Disease Relevance 0 Pain Relevance 0.72
In contrast, longer term (48 and 72 h) co-incubation of the Caco-2 cells with capsaicin (50 and 100 microM) increased P-gp activity through an up-regulation of cellular P-gp protein and MDR1 mRNA levels.
Positive_regulation (increased) of P-gp in Caco-2 associated with qutenza
3) Confidence 0.55 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16674925 Disease Relevance 0 Pain Relevance 0.71
In contrast, longer term (48 and 72 h) co-incubation of the Caco-2 cells with capsaicin (50 and 100 microM) increased P-gp activity through an up-regulation of cellular P-gp protein and MDR1 mRNA levels.
Positive_regulation (increased) of P-gp protein in Caco-2 associated with qutenza
4) Confidence 0.55 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16674925 Disease Relevance 0 Pain Relevance 0.72
In contrast, multidrug resistance-associated proteins Mrp1, Mrp2, Mrp3, and Mrp4, as well as multidrug resistance proteins Mdr1a and Mdr1b genes, were increased following APAP.
Positive_regulation (increased) of Mdr1a associated with paracetamol
5) Confidence 0.49 Published 2007 Journal J. Toxicol. Environ. Health Part A Section Abstract Doc Link 17934960 Disease Relevance 0.30 Pain Relevance 0.86
The transport of methadone was increased in presence of P-gp inhibitors verapamil and quinidine.
Positive_regulation (increased) of P-gp associated with methadone
6) Confidence 0.47 Published 1999 Journal Fundam Clin Pharmacol Section Abstract Doc Link 10456292 Disease Relevance 0 Pain Relevance 1.00
RESULTS: Morphine-associated antinociception was increased significantly in the mdr1a(-/-) mice.
Positive_regulation (increased) of mdr1a
7) Confidence 0.47 Published 2000 Journal Pharm. Res. Section Body Doc Link 10955852 Disease Relevance 0 Pain Relevance 0
From each series (morphine and meperidine analogs) we selected potential candidate opioids that are non-P-gp substrates and conducted in vivo assessments of their antinociceptive effects using P-gp knockout and P-gp competent mice. 6-Desoxymorphine, meperidine and N-phenylbutyl normeperidine did not significantly (p>0.05) stimulate the basal P-gp ATPase activity, where, the fold stimulations of the basal P-gp ATPase activity were 1.01+/-0.11, 1.51+/-0.29 and 1.10+/-0.23, respectively.
Neg (not) Positive_regulation (stimulate) of P-gp associated with targeted disruption, antinociceptive, opioid and morphine
8) Confidence 0.45 Published 2009 Journal Int J Pharm Section Abstract Doc Link 19481690 Disease Relevance 0.15 Pain Relevance 1.45
From each series (morphine and meperidine analogs) we selected potential candidate opioids that are non-P-gp substrates and conducted in vivo assessments of their antinociceptive effects using P-gp knockout and P-gp competent mice. 6-Desoxymorphine, meperidine and N-phenylbutyl normeperidine did not significantly (p>0.05) stimulate the basal P-gp ATPase activity, where, the fold stimulations of the basal P-gp ATPase activity were 1.01+/-0.11, 1.51+/-0.29 and 1.10+/-0.23, respectively.
Positive_regulation (stimulations) of P-gp associated with targeted disruption, antinociceptive, opioid and morphine
9) Confidence 0.45 Published 2009 Journal Int J Pharm Section Abstract Doc Link 19481690 Disease Relevance 0.15 Pain Relevance 1.40
The brain distribution and antinociceptive activity of methadone were enhanced (p < 0.05) in P-gp knockout mice.
Positive_regulation (enhanced) of P-gp in brain associated with targeted disruption, methadone and antinociceptive
10) Confidence 0.43 Published 2009 Journal J Pharm Sci Section Abstract Doc Link 19370547 Disease Relevance 0.18 Pain Relevance 1.47
Oxycodone stimulated the P-gp ATPase activity in a concentration-dependant manner.
Positive_regulation (stimulated) of P-gp associated with oxycodone
11) Confidence 0.24 Published 2007 Journal J Pharm Sci Section Abstract Doc Link 17593551 Disease Relevance 0 Pain Relevance 0.80
The P-gp protein levels were increased by 1.3-4.0 folds while paclitaxel's tissue distributions were decreased by 38-90% (p < 0.05) in oxycodone-treated rats.
Positive_regulation (increased) of P-gp protein associated with oxycodone
12) Confidence 0.24 Published 2007 Journal J Pharm Sci Section Abstract Doc Link 17593551 Disease Relevance 0 Pain Relevance 0.80
A high dose of oxymatrine (30 mg/kg) also significantly inhibited the dramatic increase in expression of morphine-induced P-glycoprotein (P-gp), an ATP-dependent efflux pump acting at the blood-brain barrier, by Western blot analysis.
Positive_regulation (induced) of P-gp in brain associated with morphine
13) Confidence 0.21 Published 2010 Journal Integr Cancer Ther Section Abstract Doc Link 20587445 Disease Relevance 0 Pain Relevance 1.20
I think there are not an awful lot of examples, since we've been doing the training come to mind referring here there and everywhere, but just in general because of the training I've thought lets just stop and look, what are we actually achieving [PGP02]
Positive_regulation (achieving) of PGP02
14) Confidence 0.15 Published 2008 Journal BMC Fam Pract Section Body Doc Link PMC2533666 Disease Relevance 0.23 Pain Relevance 0.09
Taken together, these results provide preliminary evidence that cannabinoids do not exacerbate P-gp mediated MDR.
Neg (not) Positive_regulation (exacerbate) of P-gp associated with cannabinoid
15) Confidence 0.12 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16458258 Disease Relevance 0.20 Pain Relevance 0.32
Taken together, these results provide preliminary evidence that cannabinoids do not exacerbate P-gp mediated MDR.
Neg (not) Positive_regulation (mediated) of P-gp associated with cannabinoid
16) Confidence 0.12 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16458258 Disease Relevance 0.20 Pain Relevance 0.32
Furthermore, feeding WT mice with diet containing the mouse SXR ligand, PCN, for two weeks strongly induced SXR target genes CYP3A11, GSTA1, and MDR1a expression, but failed to induce CYP24 expression in both liver and intestine (Zhou, C., unpublished observation).
Positive_regulation (induced) of MDR1a in intestine
17) Confidence 0.08 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.16 Pain Relevance 0.05
The apparent uptake of PTZ by the brain increased in the presence of P-gp inhibitors such as cyclosporin A, quinidine, verapamil and vinblastine after the carotid injection.
Positive_regulation (presence) of P-gp in brain associated with fortral
18) Confidence 0.06 Published 2004 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15187451 Disease Relevance 0 Pain Relevance 0.84
Furthermore, feeding WT mice with diet containing the mouse SXR ligand, PCN, for two weeks strongly induced SXR target genes CYP3A11, GSTA1, and MDR1a expression, but failed to induce CYP24 expression in both liver and intestine (Zhou, C., unpublished observation).
Positive_regulation (induced) of MDR1a in liver
19) Confidence 0.03 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.16 Pain Relevance 0.05
The impact of morphine-mediated P-gp induction observed in large vessels remains to be determined in terms of brain disposition of drugs that are P-gp substrates.
Positive_regulation (induction) of P-gp in vessels associated with morphine
20) Confidence 0.02 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18761714 Disease Relevance 0 Pain Relevance 0.76

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