INT83712

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Context Info
Confidence 0.69
First Reported 1997
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 19
Total Number 21
Disease Relevance 13.09
Pain Relevance 6.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) aging (Nos3) Golgi apparatus (Nos3)
cytoplasm (Nos3) signal transduction (Nos3) oxidoreductase activity (Nos3)
Anatomy Link Frequency
edge 2
Lungs 2
plasma 1
spinal cord 1
bone marrow 1
Nos3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
calcitonin gene related peptide 5 99.88 Very High Very High Very High
Cholecystokinin 72 99.76 Very High Very High Very High
Spinal cord 10 99.32 Very High Very High Very High
Dynorphin 2 98.92 Very High Very High Very High
Analgesic 2 98.50 Very High Very High Very High
cytokine 4 98.26 Very High Very High Very High
intrathecal 1 97.92 Very High Very High Very High
anesthesia 8 97.76 Very High Very High Very High
ketamine 3 97.36 Very High Very High Very High
Arthritis 9 96.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 7 100.00 Very High Very High Very High
Necrosis 3 100.00 Very High Very High Very High
Cancer 3 100.00 Very High Very High Very High
Natriuresis 2 100.00 Very High Very High Very High
Hypoxia 2 99.92 Very High Very High Very High
Nervous System Injury 3 99.60 Very High Very High Very High
Peptic Ulcer 11 97.36 Very High Very High Very High
Arthritis 9 96.44 Very High Very High Very High
Ulcers 103 96.12 Very High Very High Very High
Injury 67 96.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of CCK-A receptor mRNA and cNOS mRNA was significantly increased in rats treated with CCK-8 and camostate, whereas CCK-B receptor mRNA remained unaffected.
Transcription (mRNA) of cNOS associated with cholecystokinin
1) Confidence 0.69 Published 1999 Journal Regul. Pept. Section Abstract Doc Link 10458643 Disease Relevance 0.88 Pain Relevance 0.77
Immunohistochemical and in situ hybridization techniques were used for detecting protein and mRNA expressions for vascular endothelial growth factors (VEGF), basic fibroblast growth factors (bFGF) and TGF-beta(1), endothelial nitric oxide synthase (eNOS), and anti- and pro-apoptotic markers.
Transcription (expressions) of eNOS in fibroblast
2) Confidence 0.62 Published 2002 Journal Diabetologia Section Body Doc Link 11914746 Disease Relevance 0.09 Pain Relevance 0
However, after culture only low levels of eNOS protein was found while no eNOS and nNOS mRNA and protein could be detected.
Transcription (found) of eNOS
3) Confidence 0.58 Published 2005 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 16364050 Disease Relevance 0.28 Pain Relevance 0.24
We found that (1) expression of iNOS and eNOS mRNA in endothelial cells was increased by chronic exercise and (2) chronic exercise blunted phenylephrine-induced vascular responses, probably by increasing NO release via iNOS.
Transcription (expression) of eNOS in endothelial cells
4) Confidence 0.52 Published 2002 Journal J. Biomed. Sci. Section Abstract Doc Link 11914582 Disease Relevance 0 Pain Relevance 0.09
Detectable signals for CCK-A and B receptor mRNAs as well as for cNOS mRNA expression were recorded by RT-PCR in the vehicle control gastric mucosa.
Transcription (expression) of cNOS associated with cholecystokinin
5) Confidence 0.52 Published 1999 Journal Regul. Pept. Section Abstract Doc Link 10458643 Disease Relevance 0.92 Pain Relevance 0.79
The expression of CCK-A receptor mRNA and cNOS mRNA was significantly increased in rats treated with CCK-8 and camostate, whereas CCK-B receptor mRNA remained unaffected.
Transcription (mRNA) of cNOS associated with cholecystokinin
6) Confidence 0.52 Published 1999 Journal Regul. Pept. Section Abstract Doc Link 10458643 Disease Relevance 0.88 Pain Relevance 0.77
[Effects of dynorphin A1-17 on the activities, immunoreactivities and mRNA expression of cNOS and iNOS in rat spinal cord and their mechanisms].
Transcription (expression) of cNOS in spinal cord associated with dynorphin, analgesic and spinal cord
7) Confidence 0.51 Published 1997 Journal Sheng Li Ke Xue Jin Zhan Section Title Doc Link 10921077 Disease Relevance 0.42 Pain Relevance 0.67
The mRNA of iNOS as well as eNOS and nNOS can be reliably detected in the mouse bone marrow [15].
Transcription (detected) of eNOS in bone marrow
8) Confidence 0.51 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0 Pain Relevance 0
In addition, rosuvastatin inhibited iNOS mRNA and protein expression and increased eNOS mRNA and protein expression.
Transcription (expression) of eNOS
9) Confidence 0.50 Published 2010 Journal Brain Res. Section Abstract Doc Link 20513366 Disease Relevance 0.68 Pain Relevance 0.45
Expression of cNOS mRNA was detected by RT-PCR in the intact gastric mucosa as well as at the edge of gastric ulcers treated with both, vehicle and melatonin, while iNOS mRNA that was undetectable in the intact gastric mucosa, appeared during ulcer healing and especially this was strongly up-regulated in the melatonin-treated gastric mucosa.
Transcription (Expression) of cNOS in edge associated with ulcers and peptic ulcer
10) Confidence 0.48 Published 2002 Journal J. Pineal Res. Section Abstract Doc Link 12074098 Disease Relevance 1.33 Pain Relevance 0.09
Expression of cNOS mRNA was detected by RT-PCR in the intact gastric mucosa as well as at the edge of gastric ulcers treated with both, vehicle and melatonin, while iNOS mRNA that was undetectable in the intact gastric mucosa, appeared during ulcer healing and especially this was strongly up-regulated in the melatonin-treated gastric mucosa.
Transcription (detected) of cNOS in edge associated with ulcers and peptic ulcer
11) Confidence 0.48 Published 2002 Journal J. Pineal Res. Section Abstract Doc Link 12074098 Disease Relevance 1.33 Pain Relevance 0.09
The aim of the present study was (1) to investigate the effect of acylated ghrelin on the formation and healing of acute gastric mucosal lesions induced by ischemia-reperfusion and gastric mucosal blood flow in rats; (2) to analyse the effects of the deactivation of afferent sensory nerves with capsaicin and of the inhibition of nitric oxide (NO)-synthase by NG-nitro-l-arginine (l-NNA) on the ghrelin-induced protection; (3) to examine the influence of ghrelin on nuclear factor-kappa B (NF-kappaB) activation and on release of proinflammatory cytokines, such as tumor necrosis factor-alpha, (4) to assess the effect of ghrelin on the mRNA expression of constitutive nitric oxide synthase (cNOS), calcitonin gene related peptide (CGRP) and angiogenesis related proteins such as hypoxia inducible factor-1 alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF), and (5) to determine the effect of ischemia/reperfusion on the gastric mucosa expression of ghrelin in rats without and with administration of exogenous hormone.
Transcription (expression) of cNOS in sensory nerves associated with calcitonin gene related peptide, necrosis, qutenza, hypoxia, cancer, ischemia and cytokine
12) Confidence 0.46 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16581065 Disease Relevance 0.88 Pain Relevance 0.46
The mRNA expression for both nNOS and endothelial nitric oxide synthases (eNOS) presented no noticeable differences among the groups.
Transcription (expression) of eNOS
13) Confidence 0.38 Published 2009 Journal Brain Res. Section Abstract Doc Link 19769951 Disease Relevance 0.89 Pain Relevance 0.63
The expression of ANP and natriuretic peptide receptor-A (NPR-A) mRNA was determined in the kidney, as was that of endothelial NO synthase (NOS) proteins.
Spec (determined) Transcription (expression) of endothelial NO synthase in kidney associated with natriuresis
14) Confidence 0.30 Published 2004 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 15053815 Disease Relevance 0.28 Pain Relevance 0.09
Indeed, transcripts for eNOS and inducible nitric oxide synthase (iNOS) were found to be up-regulated on both transcriptional and translational levels during arteriogenesis [4].
Transcription (transcripts) of eNOS
15) Confidence 0.30 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2949609 Disease Relevance 0.15 Pain Relevance 0.07
RT-PCR was employed to determine the iNOS and endothelial NOS (eNOS) mRNA.
Spec (determine) Transcription (determine) of eNOS
16) Confidence 0.30 Published 2005 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15821434 Disease Relevance 0.59 Pain Relevance 0
OBJECTIVE AND DESIGN: The purpose of the present study was to evaluate the effect of urethane, pentobarbital sodium and ketamine-xylazine anesthesia upon constitutive and inducible cyclooxygenase (COX-1; COX-2) and nitric oxide synthase (eNOS; iNOS) mRNA levels in the lung.
Transcription (levels) of eNOS in lung associated with anesthesia and ketamine
17) Confidence 0.30 Published 2000 Journal Inflamm. Res. Section Abstract Doc Link 11211925 Disease Relevance 0 Pain Relevance 0.15
Lungs were excised 2 or 24 h after resuscitation, and mRNA levels of tumor necrosis factor alpha (TNF-alpha), intercellular adhesion molecule-1 (ICAM-1), nitric oxide synthase 2 (iNOS), nitric oxide synthase 3, hypoxia-inducible factor 1 alpha, and heme oxygenase 1 (HO-1) were measured.
Transcription (levels) of nitric oxide synthase 3 in Lungs associated with necrosis, hypoxia, cancer and adhesions
18) Confidence 0.18 Published 2009 Journal ASAIO J. Section Abstract Doc Link 19625952 Disease Relevance 1.35 Pain Relevance 0.37
Subsequent to enhanced transcription and expression of eNOS and iNOS, both total NOS activity and plasma NOS levels were increased from 12 to 24 hours after the double-hit injury.
Transcription (transcription) of eNOS in plasma associated with injury
19) Confidence 0.12 Published 2010 Journal Crit Care Section Body Doc Link PMC2945093 Disease Relevance 0.54 Pain Relevance 0.03
Although there were no statistically significant increases in mRNA at any time point, eNOS mRNA tended to be increased compared with the control group at 4 hours and iNOS mRNA from 4 to 12 hours post-injury (P > 0.05; Figures 3a and 4a).


Transcription (tended) of eNOS associated with injury
20) Confidence 0.12 Published 2010 Journal Crit Care Section Body Doc Link PMC2945093 Disease Relevance 0.65 Pain Relevance 0

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