INT83713

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Context Info
Confidence 0.67
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.92
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) aging (Nos3) Golgi apparatus (Nos3)
cytoplasm (Nos3) signal transduction (Nos3) oxidoreductase activity (Nos3)
Anatomy Link Frequency
plasma 4
sympathetic 2
Nos3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 24 99.58 Very High Very High Very High
Somatostatin 4 89.96 High High
Sciatic nerve 1 88.76 High High
Eae 1 87.84 High High
hyperexcitability 1 86.24 High High
Stimulus evoked pain 2 84.36 Quite High
qutenza 2 83.08 Quite High
Peripheral nerve injury 2 75.00 Quite High
Inflammation 13 73.32 Quite High
Neuropathic pain 2 69.80 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 3 99.80 Very High Very High Very High
Injury 65 95.48 Very High Very High Very High
Ulcers 19 90.00 High High
Hypersensitivity 3 84.36 Quite High
Pain 2 83.68 Quite High
Sepsis 40 78.84 Quite High
Adult Respiratory Distress Syndrome 36 78.40 Quite High
Increased Venous Pressure Under Development 2 77.28 Quite High
INFLAMMATION 15 73.32 Quite High
Neuropathic Pain 2 69.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of CCK-A receptor mRNA and cNOS mRNA was significantly increased in rats treated with CCK-8 and camostate, whereas CCK-B receptor mRNA remained unaffected.
Positive_regulation (increased) of Transcription (mRNA) of cNOS associated with cholecystokinin
1) Confidence 0.67 Published 1999 Journal Regul. Pept. Section Abstract Doc Link 10458643 Disease Relevance 0.88 Pain Relevance 0.78
Subsequent to enhanced transcription and expression of eNOS and iNOS, both total NOS activity and plasma NOS levels were increased from 12 to 24 hours after the double-hit injury.
Positive_regulation (enhanced) of Transcription (transcription) of eNOS in plasma associated with injury
2) Confidence 0.12 Published 2010 Journal Crit Care Section Body Doc Link PMC2945093 Disease Relevance 0.55 Pain Relevance 0.03
Moreover, we show that following nerve injury there is increased ecNOS-mRNA expression within the lumbar sympathetic ganglia, and that axoplasmic transport in sympathetic and other axons rather than local non-neural synthesis accounts for its accumulation in nerve fibres.
Positive_regulation (increased) of Transcription (expression) of ecNOS in sympathetic associated with nervous system injury
3) Confidence 0.09 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10947811 Disease Relevance 0.95 Pain Relevance 0.54
Subsequent to enhanced transcription and expression of eNOS and iNOS, both total NOS activity and plasma NOS levels were increased from 12 to 24 hours after the double-hit injury.
Positive_regulation (enhanced) of Transcription (transcription) of eNOS in plasma associated with injury
4) Confidence 0.08 Published 2010 Journal Crit Care Section Body Doc Link PMC2945093 Disease Relevance 0.55 Pain Relevance 0.03

General Comments

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