INT83716

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Context Info
Confidence 0.23
First Reported 1999
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.43
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (CSF1) cell proliferation (CSF1) extracellular space (CSF1)
extracellular region (CSF1) plasma membrane (CSF1)
Anatomy Link Frequency
macrophage 2
CSF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 3 99.56 Very High Very High Very High
Inflammation 1 98.88 Very High Very High Very High
Pain 1 62.12 Quite High
cytokine 4 50.00 Quite Low
aspirin 3 50.00 Quite Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 3 99.56 Very High Very High Very High
Metastasis 2 75.00 Quite High
Breast Cancer 2 68.76 Quite High
Pain 1 62.12 Quite High
Increased Venous Pressure Under Development 1 5.00 Very Low Very Low Very Low
Coronary Artery Disease 1 5.00 Very Low Very Low Very Low
Bone Cancer 1 5.00 Very Low Very Low Very Low
Acute Coronary Syndrome 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prognostic value of C-reactive protein, fibrinogen, interleukin-6, and macrophage colony stimulating factor in severe unstable angina.
Negative_regulation (value) of colony stimulating factor in macrophage associated with angina
1) Confidence 0.23 Published 2002 Journal Clin Cardiol Section Title Doc Link 12430780 Disease Relevance 0.10 Pain Relevance 0.15
Treatment of HDS cells with gefitinib produced a significant reduction in the levels of secreted macrophage colony-stimulating factor (M-CSF) and cell-associated receptor activator of NF-kappaB ligand (RANKL) in both cell lines, as assessed by using specific ELISA and Western blotting techniques.
Negative_regulation (reduction) of M-CSF in macrophage
2) Confidence 0.13 Published 2005 Journal Endocr. Relat. Cancer Section Abstract Doc Link 15947117 Disease Relevance 0.27 Pain Relevance 0.06
MCSF, IL-6, and CRP were all reduced after 6 weeks of aspirin treatment (P<0.05).
Negative_regulation (reduced) of MCSF
3) Confidence 0.10 Published 1999 Journal Circulation Section Body Doc Link 10458713 Disease Relevance 0.07 Pain Relevance 0

General Comments

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