INT83735

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Context Info
Confidence 0.77
First Reported 1999
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 41
Total Number 45
Disease Relevance 22.90
Pain Relevance 5.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Foxm1) embryo development (Foxm1) DNA binding (Foxm1)
transcription factor binding (Foxm1) cytoplasm (Foxm1)
Anatomy Link Frequency
lobe 3
endocrine cells 2
basal cell 2
spinal 1
neuronal 1
Foxm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid 145 100.00 Very High Very High Very High
agonist 76 100.00 Very High Very High Very High
Sciatic nerve 1 100.00 Very High Very High Very High
cytokine 80 99.84 Very High Very High Very High
Inflammation 635 99.80 Very High Very High Very High
Neuropathic pain 4 99.44 Very High Very High Very High
Peripheral nerve injury 2 96.76 Very High Very High Very High
psoriasis 15 94.12 High High
potassium channel 2 92.40 High High
Neurotransmitter 6 92.36 High High
Disease Link Frequency Relevance Heat
Lung Cancer 1116 100.00 Very High Very High Very High
Cancer 918 100.00 Very High Very High Very High
Nervous System Injury 11 100.00 Very High Very High Very High
INFLAMMATION 594 99.80 Very High Very High Very High
Contact Dermatitis 145 99.76 Very High Very High Very High
Diabetes Mellitus 120 99.60 Very High Very High Very High
Neuropathic Pain 5 99.44 Very High Very High Very High
Basal Cell Neoplasms 2 99.44 Very High Very High Very High
Disease 114 99.28 Very High Very High Very High
Papillomavirus Infection 28 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Foxm1 overexpression did not enhance ?
Gene_expression (overexpression) of Foxm1
1) Confidence 0.77 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.23 Pain Relevance 0.03
Indeed, Foxm1 expression was upregulated twofold in control islets 6 days following PPx versus sham (Fig. 2), suggesting that FoxM1 plays a role in the regenerative response of endocrine cells.
Gene_expression (expression) of Foxm1 in endocrine cells
2) Confidence 0.77 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0 Pain Relevance 0
Despite FoxM1 overexpression within islets (online appendix Fig.
Gene_expression (overexpression) of FoxM1 in appendix
3) Confidence 0.77 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.35 Pain Relevance 0.05
The average number of insulin+ cell groupings in the splenic lobe of both FoxM1?
Gene_expression (lobe) of FoxM1 in lobe
4) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0 Pain Relevance 0
FOXM1 overexpression did not affect ?
Gene_expression (overexpression) of FOXM1
5) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.14 Pain Relevance 0
No difference in the number of Ngn3+ ductal epithelial cells was detected between control and FoxM1?
Gene_expression (detected) of FoxM1 in epithelial cells
6) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.22 Pain Relevance 0.03
For example, the FoxM1 targets Cdc25A and Cdc25B (cell division cycle 25 homolog A and B, respectively) dephosphorylate and activate cyclin-dependent kinase 2 (Cdk2) and Cdk1, respectively (12).
Gene_expression (targets) of FoxM1
7) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.28 Pain Relevance 0
To determine whether Foxm1 overexpression affects pancreas and ?
Spec (whether) Gene_expression (overexpression) of Foxm1 in pancreas
8) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.30 Pain Relevance 0.04
Since these channels are found in brain, radiolabeled WIN 17317-3 was synthesized to probe neuronal K(v)1 channels.
Gene_expression (synthesized) of WIN in neuronal
9) Confidence 0.66 Published 1999 Journal Biochemistry Section Abstract Doc Link 10460170 Disease Relevance 0 Pain Relevance 0.24
Although all proliferating cells express FoxM1, certain cell types are more profoundly affected than others by Foxm1 deletion.
Gene_expression (express) of FoxM1
10) Confidence 0.60 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.12 Pain Relevance 0
FoxM1 is highly expressed within pancreatic endocrine cells during embryogenesis and is downregulated with age (9), corresponding with reduced ?
Gene_expression (expressed) of FoxM1 in endocrine cells
11) Confidence 0.60 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.41 Pain Relevance 0.04
The current study utilized quantitative RT-PCR on islet RNA to assess changes in Foxm1 expression following PPx.
Gene_expression (expression) of Foxm1
12) Confidence 0.60 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0 Pain Relevance 0
Unfortunately, antibodies to detect FoxM1 protein in mouse tissue do not currently exist, precluding precise identification of the cell population(s) in which FoxM1 expression or localization changes with time and after PPx.
Gene_expression (expression) of FoxM1
13) Confidence 0.60 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0 Pain Relevance 0
Both MDMA and cannabinoid agonists such as WIN 55212-2 (WIN) produce rewarding effects in mice [13,14] and rats when administered alone [15].
Gene_expression (produce) of WIN associated with cannabinoid and agonist
14) Confidence 0.58 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2858089 Disease Relevance 0.15 Pain Relevance 0.65
Both MDMA and cannabinoid agonists such as WIN 55212-2 (WIN) produce rewarding effects in mice [13,14] and rats when administered alone [15].
Gene_expression (produce) of WIN associated with cannabinoid and agonist
15) Confidence 0.58 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2858089 Disease Relevance 0.15 Pain Relevance 0.65
-cell regeneration following PPx, we utilized Rosa26-FoxM1 Tg mice that constitutively and ubiquitously overexpress human FoxM1 (23).
Gene_expression (overexpress) of FoxM1 associated with targeted disruption
16) Confidence 0.58 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.35 Pain Relevance 0.04
Additionally, we observed significant upregulation of known FoxM1 targets, including Plk1, Cenp-a, Birc5/survivin, and Ccnb1 (Fig. 2).
Gene_expression (targets) of FoxM1
17) Confidence 0.58 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.11 Pain Relevance 0
However, FoxM1?
Gene_expression (However) of FoxM1
18) Confidence 0.58 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.08 Pain Relevance 0
-cell size was significantly reduced specifically within the splenic lobe of FoxM1?
Gene_expression (lobe) of FoxM1 in lobe
19) Confidence 0.58 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.09 Pain Relevance 0
Similarly, the average islet size within the duodenal lobe of control mice trended toward an increase following PPx versus sham, but no expansion was observed in FoxM1?
Neg (no) Gene_expression (observed) of FoxM1 in lobe
20) Confidence 0.58 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.07 Pain Relevance 0

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