INT83736

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Context Info
Confidence 0.53
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 0.47
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mbp)
Mbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Action potential 8 99.62 Very High Very High Very High
tetrodotoxin 4 98.54 Very High Very High Very High
Hippocampus 9 95.12 Very High Very High Very High
Multiple sclerosis 3 88.32 High High
Pyramidal cell 1 52.80 Quite High
Disease Link Frequency Relevance Heat
Demyelinating Disease 6 88.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This change was blocked by tetrodotoxin, indicating that axonally generated action potentials were necessary to regulate the phosphorylation state of MBP.
Regulation (regulate) of Phosphorylation (phosphorylation) of MBP associated with action potential and tetrodotoxin
1) Confidence 0.53 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10460230 Disease Relevance 0 Pain Relevance 0.34
Removal of extracellular calcium also blocked the changes in MBP phosphorylation.
Regulation (changes) of Phosphorylation (phosphorylation) of MBP
2) Confidence 0.46 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10461899 Disease Relevance 0.14 Pain Relevance 0.28
Using a phosphospecific antibody that recognizes the predominant MAPK phosphorylation site in MBP, Thr95, we found that MBP phosphorylation is regulated by high-frequency stimulation but not low-frequency stimulation of the alveus.
Regulation (regulated) of Phosphorylation (phosphorylation) of MBP
3) Confidence 0.46 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10461899 Disease Relevance 0.18 Pain Relevance 0.30
It is interesting that the change in MBP phosphorylation was attenuated by the reactive oxygen species scavengers superoxide dismutase and catalase and the nitric oxide synthase inhibitor N-nitro-L-arginine.
Regulation (change) of Phosphorylation (phosphorylation) of MBP
4) Confidence 0.34 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10461899 Disease Relevance 0.15 Pain Relevance 0.30

General Comments

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