INT83737

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.81
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 13
Disease Relevance 1.63
Pain Relevance 3.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mbp)
Anatomy Link Frequency
hippocampus 2
oligodendrocyte 2
neuronal 1
Mbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 29 99.54 Very High Very High Very High
Action potential 26 99.36 Very High Very High Very High
tetrodotoxin 13 98.28 Very High Very High Very High
Multiple sclerosis 10 97.80 Very High Very High Very High
Pyramidal cell 3 52.80 Quite High
Disease Link Frequency Relevance Heat
Demyelinating Disease 20 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High-frequency, but not low-frequency, action potential firing in myelinated CA1 axons of the hippocampus resulted in increased phosphorylation of the oligodendrocyte-specific protein myelin basic protein (MBP).
Phosphorylation (phosphorylation) of MBP in oligodendrocyte associated with action potential and hippocampus
1) Confidence 0.81 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10460230 Disease Relevance 0 Pain Relevance 0.31
High-frequency, but not low-frequency, action potential firing in myelinated CA1 axons of the hippocampus resulted in increased phosphorylation of the oligodendrocyte-specific protein myelin basic protein (MBP).
Phosphorylation (phosphorylation) of myelin basic protein in oligodendrocyte associated with action potential and hippocampus
2) Confidence 0.81 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10460230 Disease Relevance 0 Pain Relevance 0.31
This change was blocked by tetrodotoxin, indicating that axonally generated action potentials were necessary to regulate the phosphorylation state of MBP.
Phosphorylation (phosphorylation) of MBP associated with action potential and tetrodotoxin
3) Confidence 0.71 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10460230 Disease Relevance 0 Pain Relevance 0.34
Thus, we propose that during periods of increased neuronal activity, calcium activates axonal nitric oxide synthase, which generates the intercellular messengers nitric oxide and superoxide and regulates the phosphorylation state of MBP by MAPK.
Phosphorylation (phosphorylation) of MBP in neuronal
4) Confidence 0.61 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10461899 Disease Relevance 0.12 Pain Relevance 0.25
Myelin basic protein (MBP) phosphorylation is a complex regulatory process that modulates the contribution of MBP to the stability of the myelin sheath.
Phosphorylation (phosphorylation) of MBP
5) Confidence 0.61 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10461899 Disease Relevance 0.16 Pain Relevance 0.15
Recent research has demonstrated the modulation of MBP phosphorylation by mitogen-activated protein kinase (MAPK) during myelinogenesis and in the demyelinating disease multiple sclerosis.
Phosphorylation (phosphorylation) of MBP associated with multiple sclerosis and demyelinating disease
6) Confidence 0.61 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10461899 Disease Relevance 0.19 Pain Relevance 0.24
Here we investigated the physiological regulation of MBP phosphorylation by MAPK during neuronal activity in the alveus, the myelinated output fibers of the hippocampus.
Phosphorylation (phosphorylation) of MBP in hippocampus associated with hippocampus
7) Confidence 0.61 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10461899 Disease Relevance 0.19 Pain Relevance 0.28
Using a phosphospecific antibody that recognizes the predominant MAPK phosphorylation site in MBP, Thr95, we found that MBP phosphorylation is regulated by high-frequency stimulation but not low-frequency stimulation of the alveus.
Phosphorylation (phosphorylation) of MBP
8) Confidence 0.61 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10461899 Disease Relevance 0.18 Pain Relevance 0.30
Regulation of myelin basic protein phosphorylation by mitogen-activated protein kinase during increased action potential firing in the hippocampus.
Phosphorylation (phosphorylation) of myelin basic protein in hippocampus associated with action potential and hippocampus
9) Confidence 0.61 Published 1999 Journal J. Neurochem. Section Title Doc Link 10461899 Disease Relevance 0.17 Pain Relevance 0.27
It is interesting that the change in MBP phosphorylation was attenuated by the reactive oxygen species scavengers superoxide dismutase and catalase and the nitric oxide synthase inhibitor N-nitro-L-arginine.
Phosphorylation (phosphorylation) of MBP
10) Confidence 0.61 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10461899 Disease Relevance 0.15 Pain Relevance 0.30
Removal of extracellular calcium also blocked the changes in MBP phosphorylation.
Phosphorylation (phosphorylation) of MBP
11) Confidence 0.61 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10461899 Disease Relevance 0.14 Pain Relevance 0.28
Myelin basic protein (MBP) phosphorylation is a complex regulatory process that modulates the contribution of MBP to the stability of the myelin sheath.
Phosphorylation (phosphorylation) of Myelin basic protein
12) Confidence 0.61 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10461899 Disease Relevance 0.16 Pain Relevance 0.15
Using a phosphospecific antibody that recognizes the predominant MAPK phosphorylation site in MBP, Thr95, we found that MBP phosphorylation is regulated by high-frequency stimulation but not low-frequency stimulation of the alveus.
Phosphorylation (phosphorylation) of MBP
13) Confidence 0.61 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10461899 Disease Relevance 0.18 Pain Relevance 0.30

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox