INT83743

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.76
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 0.93
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SULT1B1) small molecule metabolic process (SULT1B1) cytoplasm (SULT1B1)
Anatomy Link Frequency
EST 1
SULT1B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
monoamine 1 99.00 Very High Very High Very High
Paracetamol 6 95.48 Very High Very High Very High
lidocaine 4 75.00 Quite High
local anesthetic 2 75.00 Quite High
Morphine 1 70.48 Quite High
chemokine 4 69.84 Quite High
cINOD 2 29.60 Quite Low
Neurotransmitter 8 29.48 Quite Low
Catecholamine 36 16.28 Low Low
Dopamine 32 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 3 92.72 High High
Colon Cancer 62 90.40 High High
Lung Cancer 2 67.12 Quite High
Hypoxia 1 66.20 Quite High
Cancer 47 62.12 Quite High
Bacterial Infection 1 59.92 Quite High
Breast Cancer 4 54.88 Quite High
Recurrence 10 49.52 Quite Low
Metastasis 8 42.40 Quite Low
INFLAMMATION 5 29.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Five cloned human sulfotransferases (STs) were used in this study, namely, the phenol-sulfating form of ST (P-PST-1), the monoamine-sulfating form of ST (M-PST), estrogen-ST (EST), ST1B2, and dehydroepiandrosterone-ST (DHEA-ST), all of which are expressed in human liver.
Gene_expression (expressed) of ST1B2 in EST associated with monoamine
1) Confidence 0.76 Published 1999 Journal Drug Metab. Dispos. Section Abstract Doc Link 10460806 Disease Relevance 0 Pain Relevance 0.40
Studies of 3-OH-BaP sulfonation by expressed human SULT1A1*1, SULT1A1*2, SULT1B1, and SULT1E1 showed that triclosan inhibited the activities of each of these purified enzymes with IC50 concentrations between 2.09 and 7.5 microM.
Gene_expression (expressed) of SULT1B1
2) Confidence 0.71 Published 2004 Journal Drug Metab. Dispos. Section Abstract Doc Link 15269185 Disease Relevance 0.06 Pain Relevance 0.24
Purified SULT1B1, SULT1C1, and SULT1C3 were crystallized in the presence of 2 mM PAP using the hanging drop method at 20 °C by mixing: for SULT1B1—2 ?
Gene_expression (mixing) of SULT1B1
3) Confidence 0.56 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1847840 Disease Relevance 0 Pain Relevance 0
Purified SULT1B1, SULT1C1, and SULT1C3 were crystallized in the presence of 2 mM PAP using the hanging drop method at 20 °C by mixing: for SULT1B1—2 ?
Gene_expression (crystallized) of SULT1B1
4) Confidence 0.56 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1847840 Disease Relevance 0 Pain Relevance 0
The SULT1B1, SULT1C1, SULT1C2, SULT1C3, and SULT4A1 genes were amplified by PCR from the Mammalian Gene Collection clones and subcloned into a modified pET28a-LIC vector.
Gene_expression (amplified) of SULT1B1
5) Confidence 0.56 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1847840 Disease Relevance 0 Pain Relevance 0
SULT1C1, SULT1C2, SULT1C3, and SULT1B1 showed similar saturation binding curves, reaching saturation at about 100 ?
Gene_expression (showed) of SULT1B1
6) Confidence 0.56 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1847840 Disease Relevance 0 Pain Relevance 0
High expression of SULT1B1 mRNA has been reported in normal colorectal samples, and it is thought to be related to carcinogenesis.30 Expression of SULT1B1 is a characteristic for normal colorectal tissue, so repression of SULT1B1 along with repression of UGT2B28 in CRC is thought to be related to tissue dedifferentiation.
Gene_expression (expression) of SULT1B1 associated with colon cancer and repression
7) Confidence 0.21 Published 2010 Journal Cancer Informatics Section Body Doc Link PMC2918356 Disease Relevance 0.87 Pain Relevance 0.06

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox