INT83744

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Context Info
Confidence 0.75
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 3.12
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SULT1E1) small molecule metabolic process (SULT1E1) nucleus (SULT1E1)
cytoplasm (SULT1E1)
Anatomy Link Frequency
liver 2
uterus 1
endometrium 1
placenta 1
body 1
SULT1E1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 17 99.60 Very High Very High Very High
agonist 39 99.24 Very High Very High Very High
monoamine 1 99.12 Very High Very High Very High
Paracetamol 12 95.48 Very High Very High Very High
endometriosis 7 94.20 High High
pain pelvic 1 86.52 High High
cINOD 1 77.60 Quite High
lidocaine 4 75.00 Quite High
local anesthetic 2 75.00 Quite High
Morphine 5 74.56 Quite High
Disease Link Frequency Relevance Heat
Acute Coronary Syndrome 19 99.96 Very High Very High Very High
INFLAMMATION 15 99.60 Very High Very High Very High
Endometriosis 9 99.32 Very High Very High Very High
Disease 9 91.12 High High
Reprotox - General 3 2 87.16 High High
Gynecological Disease 1 85.72 High High
Pathologic Constriction 3 81.88 Quite High
Coronary Artery Disease 60 80.04 Quite High
Heart Disease 6 73.88 Quite High
Neuritis 1 72.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To elucidate the intracrinology of endometriotic tissues, the authors analyze the expression of aromatase and E2-inactivating estrogen sulfotransferase (EST) in paired biopsies obtained simultaneously from the endometrium and from endometrial lesions of each of 35 patients with peritoneal or ovarian endometriosis and in cycling endometria from 33 women without endometriosis.
Spec (analyze) Gene_expression (expression) of EST in endometrium associated with endometriosis
1) Confidence 0.75 Published 2007 Journal Reprod Sci Section Abstract Doc Link 18089598 Disease Relevance 0.93 Pain Relevance 0.29
CGM’s sensitivity to detect NSTE-ACS patients was 73%.
Gene_expression (detect) of STE associated with acute coronary syndrome
2) Confidence 0.65 Published 2010 Journal GMS German Medical Science Section Body Doc Link PMC2975259 Disease Relevance 1.16 Pain Relevance 0.03
RESULTS: Of 10 heterologously expressed SULT isoforms examined, SULT1A1, SULT1A3/4, SULT1E1, and SULT2A1 all catalyzed the formation of APAP sulfate with K(m) values of 2.4, 1.5, 1.9, and 3.7 mM, respectively.
Gene_expression (expressed) of SULT1E1
3) Confidence 0.64 Published 2008 Journal Birth Defects Res. Part A Clin. Mol. Teratol. Section Body Doc Link 18232020 Disease Relevance 0 Pain Relevance 0
Studies of 3-OH-BaP sulfonation by expressed human SULT1A1*1, SULT1A1*2, SULT1B1, and SULT1E1 showed that triclosan inhibited the activities of each of these purified enzymes with IC50 concentrations between 2.09 and 7.5 microM.
Gene_expression (expressed) of SULT1E1
4) Confidence 0.60 Published 2004 Journal Drug Metab. Dispos. Section Abstract Doc Link 15269185 Disease Relevance 0.06 Pain Relevance 0.25
EST is a digitally produced alternating current sinusoidal electronic signal with associated harmonics to produce theoretically reasonable and/or scientifically documented physiological effects when applied to the human body.
Gene_expression (produced) of EST in body
5) Confidence 0.53 Published 2008 Journal Pain Physician Section Abstract Doc Link 19057635 Disease Relevance 0.97 Pain Relevance 0.63
Human UGT, SULT, NAT, and GST mRNA were expressed in the liver of the chimeric mice, and UGT2B7, SULT1E1, SULT2A1, and GSTA1 proteins could be detected.
Gene_expression (detected) of SULT1E1 in liver
6) Confidence 0.42 Published 2005 Journal Drug Metab. Dispos. Section Abstract Doc Link 15932951 Disease Relevance 0 Pain Relevance 0.07
SULT1E1 is expressed most highly in tissues that are actively engaged in estrogen metabolism, such as breast, uterus, and placenta [23–25].
Gene_expression (expressed) of SULT1E1 in placenta
7) Confidence 0.34 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0 Pain Relevance 0.10
In the rat, SULT1E1, which is more abundantly expressed in male relative to female liver, was previously reported to decrease substantially following in vivo treatment with any of the PPAR?
Gene_expression (expressed) of SULT1E1 in liver
8) Confidence 0.34 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0 Pain Relevance 0.19
Five cloned human sulfotransferases (STs) were used in this study, namely, the phenol-sulfating form of ST (P-PST-1), the monoamine-sulfating form of ST (M-PST), estrogen-ST (EST), ST1B2, and dehydroepiandrosterone-ST (DHEA-ST), all of which are expressed in human liver.
Gene_expression (expressed) of EST in EST associated with monoamine
9) Confidence 0.30 Published 1999 Journal Drug Metab. Dispos. Section Abstract Doc Link 10460806 Disease Relevance 0 Pain Relevance 0.40
SULT1E1 is expressed most highly in tissues that are actively engaged in estrogen metabolism, such as breast, uterus, and placenta [23–25].
Gene_expression (expressed) of SULT1E1 in uterus
10) Confidence 0.12 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0 Pain Relevance 0.10

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