INT8379

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Context Info
Confidence 0.60
First Reported 1987
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 26
Total Number 27
Disease Relevance 2.56
Pain Relevance 15.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Qrfp) cellular_component (Qrfp)
Anatomy Link Frequency
striatum 4
chromaffin cell 3
basal ganglia 3
cerebrospinal fluid 1
nucleus 1
Qrfp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 155 100.00 Very High Very High Very High
Enkephalin 53 100.00 Very High Very High Very High
dopamine receptor 12 100.00 Very High Very High Very High
Calcitonin gene-related peptide 11 100.00 Very High Very High Very High
Delta opioid receptors 1 99.98 Very High Very High Very High
Sciatic nerve 6 99.78 Very High Very High Very High
Nucleus accumbens 19 99.76 Very High Very High Very High
anesthesia 7 99.74 Very High Very High Very High
Morphine 10 99.36 Very High Very High Very High
Eae 10 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 2 99.84 Very High Very High Very High
Injury 4 99.24 Very High Very High Very High
Convulsion 7 97.12 Very High Very High Very High
Nervous System Injury 4 96.68 Very High Very High Very High
Neuropathic Pain 2 95.76 Very High Very High Very High
Peripheral Primitive Neuroectodermal Tumors 3 95.64 Very High Very High Very High
Affective Disorder 2 85.00 Quite High
Tics 1 79.40 Quite High
Necrosis 6 75.00 Quite High
Cancer 6 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differential regulation of the tyrosine hydroxylase and enkephalin neuropeptide transmitter genes in rat PC12 cells by short chain fatty acids: concentration-dependent effects on transcription and RNA stability.
Regulation (regulation) of neuropeptide associated with neuropeptide and enkephalin
1) Confidence 0.60 Published 2007 Journal Brain Res. Section Title Doc Link 17174279 Disease Relevance 0 Pain Relevance 0.42
Differential regulation of neuropeptide and proto-oncogene mRNA content in the hippocampus following recurrent seizures.
Regulation (regulation) of neuropeptide in hippocampus associated with anesthesia, convulsion, neuropeptide and hippocampus
2) Confidence 0.60 Published 1987 Journal Brain Res. Section Title Doc Link 3427445 Disease Relevance 0.29 Pain Relevance 0.42
In contrast, neuropeptide mRNA levels were unaffected when compared with those observed after 6 days of morphine.
Neg (unaffected) Regulation (unaffected) of neuropeptide mRNA associated with neuropeptide and morphine
3) Confidence 0.56 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10051749 Disease Relevance 0.13 Pain Relevance 1.69
Furthermore, the results suggest that the effects of risperidone on neuropeptide mRNA levels are fully accounted for by its D2 antagonism and that no indication exists for a role of 5-HT2A receptor blockade in this action.
Regulation (effects) of neuropeptide associated with neuropeptide
4) Confidence 0.39 Published 1998 Journal Synapse Section Abstract Doc Link 9517839 Disease Relevance 0 Pain Relevance 0.32
This preferential postsynaptic localization, together with the reported "morphine modulating" action of this peptide, support the proposal of a role for neuropeptide FF in intraspinal modulation of nociceptive input.
Regulation (modulation) of neuropeptide associated with nociception, neuropeptide and morphine
5) Confidence 0.39 Published 1995 Journal Neuroscience Section Abstract Doc Link 8544996 Disease Relevance 0.19 Pain Relevance 0.72
Therefore, we examined effects of unilateral inactivation of RFA by infusing the same dose of muscimol unilaterally into RFA in the hemisphere opposite to the paw used for lever pressing.
Spec (examined) Regulation (effects) of RFA in lever
6) Confidence 0.33 Published 2010 Journal Frontiers in Integrative Neuroscience Section Body Doc Link PMC2965050 Disease Relevance 0 Pain Relevance 0
Furthermore, we studied the contribution of the dopamine D2 and serotonin 5-HT2A antagonist components of risperidone in establishing its effects on neuropeptide mRNA levels in the striatum.
Regulation (effects) of neuropeptide in striatum associated with dopamine, antagonist, neuropeptide and serotonin
7) Confidence 0.17 Published 1998 Journal Synapse Section Abstract Doc Link 9517839 Disease Relevance 0 Pain Relevance 0.34
Local mu and delta opioid receptors regulate amphetamine-induced behavior and neuropeptide mRNA in the striatum.
Regulation (regulate) of neuropeptide in striatum associated with neuropeptide and delta opioid receptors
8) Confidence 0.16 Published 2003 Journal Neuroscience Section Title Doc Link 14521997 Disease Relevance 0.08 Pain Relevance 0.67
Effect of reserpine and colchicine on neuropeptide mRNA levels in the rat hypothalamic paraventricular nucleus.
Regulation (Effect) of neuropeptide in nucleus associated with neuropeptide
9) Confidence 0.14 Published 1991 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 1850078 Disease Relevance 0 Pain Relevance 0.43
Our results demonstrate that the effect of a chronic haloperidol treatment on striatal dopamine receptors and neuropeptide mRNA levels is different to that of sulpiride, whereas it is similar on pituitary hormones mRNA levels.
Regulation (effect) of neuropeptide in pituitary associated with dopamine receptor and neuropeptide
10) Confidence 0.12 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7518029 Disease Relevance 0 Pain Relevance 0.37
In this report, we have analyzed the effect of lithium on two neuropeptide encoding genes that are regulated by second messenger systems; neuropeptide Y (NPY) and proenkephalin (Enk).
Regulation (regulated) of neuropeptide associated with neuropeptide
11) Confidence 0.12 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1372067 Disease Relevance 0.17 Pain Relevance 0.26
Two weeks after chronic constriction injury of adult rat sciatic nerve, galanin, neuropeptide Y and calcitonin gene-related peptide immunoreactivities were increased in fibers and cells in the gracile nucleus ipsilateral to injury.
Regulation (immunoreactivities) of neuropeptide in gracile nucleus associated with eae, injury, neuropeptide, sciatic nerve and calcitonin gene-related peptide
12) Confidence 0.04 Published 1999 Journal Neuroscience Section Abstract Doc Link 10430497 Disease Relevance 0.51 Pain Relevance 0.67
Effects of adrenal steroids on basal ganglia neuropeptide mRNA and tyrosine hydroxylase radioimmunoreactive levels in the adrenalectomized rat.
Regulation (Effects) of neuropeptide in basal ganglia associated with neuropeptide and enkephalin
13) Confidence 0.04 Published 1998 Journal J. Neurochem. Section Title Doc Link 9681476 Disease Relevance 0 Pain Relevance 0.41
To investigate the effects of type I (mineralocorticoid) and type II (glucocorticoid) receptor activation on striatal neuropeptide [preproenkephalin (PPE), preprotachykinin (PPT), and preprodynorphin (DYN)] mRNA and midbrain cholecystokinin (CCK) mRNA as well as striatal tyrosine hydroxylase radioimmunoreactivity (TH-RIC) levels, we administered either replacement levels of corticosterone (CORT; 0.5 mg/kg/day, s.c.) or pharmacological levels of deoxycorticosterone acetate (DOCA; a mineralocorticoid steroid with ability to bind to type I and type II receptors; 5 mg/kg, s.c.) to adrenalectomized adult male rats.
Spec (investigate) Regulation (effects) of neuropeptide in midbrain associated with neuropeptide, midbrain and cholecystokinin
14) Confidence 0.04 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9681476 Disease Relevance 0 Pain Relevance 0.23
Thus, regulation of immediate early and neuropeptide gene mRNA levels and immunoreactivity occurs, at least in part, at the level of transcription for the genes encoding neuropeptide Y, dynorphin, c-fos, c-jun, and NGFI-A.
Regulation (regulation) of neuropeptide associated with dynorphin and neuropeptide
15) Confidence 0.02 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8170346 Disease Relevance 0.15 Pain Relevance 0.51
Yet a major challenge for the coming decade is to understand the regulation of neuropeptide genes by physiologically and pharmacologically relevant stimuli in appropriate cell types in vivo.
Regulation (regulation) of neuropeptide associated with neuropeptide
16) Confidence 0.02 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7573416 Disease Relevance 0.06 Pain Relevance 0.18
Molecular aspects of neuropeptide regulation and function in the corpus striatum and nucleus accumbens.
Regulation (regulation) of neuropeptide in corpus striatum associated with nucleus accumbens, neuropeptide and enkephalin
17) Confidence 0.01 Published 1994 Journal Brain Res. Brain Res. Rev. Section Title Doc Link 7909470 Disease Relevance 0 Pain Relevance 1.04
The evidence gathered in many laboratories thus far indicates that these major basal ganglia peptidergic systems are modulated dynamically and sometimes in opposing ways by various neurochemical inputs which alter neuropeptide and neuropeptide mRNA levels over both short- and long-term.
Regulation (alter) of neuropeptide in basal ganglia associated with neuropeptide
18) Confidence 0.01 Published 1994 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 7909470 Disease Relevance 0.07 Pain Relevance 0.93
The changes in neuropeptide mRNA following treatment with reserpine were only found in the striatum.
Regulation (changes) of neuropeptide in striatum associated with neuropeptide
19) Confidence 0.01 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11161620 Disease Relevance 0 Pain Relevance 0.50
The evidence gathered in many laboratories thus far indicates that these major basal ganglia peptidergic systems are modulated dynamically and sometimes in opposing ways by various neurochemical inputs which alter neuropeptide and neuropeptide mRNA levels over both short- and long-term.
Regulation (alter) of neuropeptide in basal ganglia associated with neuropeptide
20) Confidence 0.01 Published 1994 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 7909470 Disease Relevance 0.07 Pain Relevance 0.93

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