INT83794

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Context Info
Confidence 0.69
First Reported 1999
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 26
Total Number 27
Disease Relevance 16.89
Pain Relevance 4.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Bcl2l1) cytosol (Bcl2l1) mitochondrion (Bcl2l1)
growth (Bcl2l1) cytoskeleton (Bcl2l1) intracellular (Bcl2l1)
Anatomy Link Frequency
liver 12
poly 2
cecum 2
megakaryocytes 2
fibroblasts 2
Bcl2l1 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 6 99.80 Very High Very High Very High
Paracetamol 95 99.44 Very High Very High Very High
antagonist 11 99.02 Very High Very High Very High
sSRI 3 92.40 High High
fluoxetine 1 90.52 High High
monoamine 1 86.88 High High
Analgesic 1 74.80 Quite High
cytokine 54 74.48 Quite High
Central nervous system 1 73.00 Quite High
Neurotransmitter 1 71.80 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 257 100.00 Very High Very High Very High
Hepatotoxicity 6 99.68 Very High Very High Very High
Stress 67 99.38 Very High Very High Very High
Breast Cancer 72 99.16 Very High Very High Very High
Cancer 336 99.04 Very High Very High Very High
Erythremia 3 98.76 Very High Very High Very High
Hematologic Neoplasms 5 98.28 Very High Very High Very High
Disease 73 97.84 Very High Very High Very High
Epstein-barr Virus 11 97.48 Very High Very High Very High
Death 83 97.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pre-exposure to a novel nutritional mixture containing a series of phytochemicals prevents acetaminophen-induced programmed and unprogrammed cell deaths by enhancing BCL-XL expression and minimizing oxidative stress in the liver.
Positive_regulation (enhancing) of Gene_expression (expression) of BCL-XL in liver associated with stress and paracetamol
1) Confidence 0.69 Published 2006 Journal Mol. Cell. Biochem. Section Title Doc Link 16902808 Disease Relevance 0.32 Pain Relevance 0.20
This investigation examined whether some aspects of the highly integrated process of acetaminophen (AAP)-induced hepatotoxicity involve down-regulation or upregulation of expression of BCL-2, BCL-X(L) and BCL-X(S) in mouse liver in vivo.
Positive_regulation (upregulation) of Gene_expression (expression) of BCL-X in liver associated with paracetamol and hepatotoxicity
2) Confidence 0.69 Published 2000 Journal Arch. Toxicol. Section Abstract Doc Link 10663392 Disease Relevance 0.72 Pain Relevance 0.47
The most dramatic changes observed in this study were: (i) substantial increase in the expression of bcl-Xl in the liver by 7-day GSPE exposure alone; (ii) significant modification bcl-Xl expression by AAP alone; and (iii) dramatic inhibition of AAP-induced modification of bcl-Xl (phosphorylation?)
Positive_regulation (increase) of Gene_expression (expression) of bcl-Xl in liver associated with paracetamol
3) Confidence 0.67 Published 1999 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 10462439 Disease Relevance 0.71 Pain Relevance 0.71
Given that Bcl-2 and Bcl-xL are capable of inhibiting anticancer drug-induced apoptosis, which is mediated by the voltage-dependent anion channel (VDAC) in the outer mitochondrial membrane, overexpression of Bcl-2 and Bcl-xL might confer resistance to chemotherapy [4].
Positive_regulation (overexpression) of Gene_expression (overexpression) of Bcl-xL associated with apoptosis
4) Confidence 0.66 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.85 Pain Relevance 0
In fact, overexpression of Bcl-2 and Bcl-xL is observed in several cancers, including hematologic malignancies, as well as a range of solid tumors, including nasopharyngeal, colorectal, prostate, and breast cancer [5-7].
Positive_regulation (overexpression) of Gene_expression (overexpression) of Bcl-xL associated with cancer, breast cancer, solid tumor and hematologic neoplasms
5) Confidence 0.66 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.87 Pain Relevance 0
This investigation examined whether some aspects of the highly integrated process of acetaminophen (AAP)-induced hepatotoxicity involve down-regulation or upregulation of expression of BCL-2, BCL-X(L) and BCL-X(S) in mouse liver in vivo.
Positive_regulation (upregulation) of Gene_expression (expression) of BCL-X in liver associated with paracetamol and hepatotoxicity
6) Confidence 0.50 Published 2000 Journal Arch. Toxicol. Section Abstract Doc Link 10663392 Disease Relevance 0.72 Pain Relevance 0.47
A novel proanthocyanidin IH636 grape seed extract increases in vivo Bcl-XL expression and prevents acetaminophen-induced programmed and unprogrammed cell death in mouse liver.
Positive_regulation (increases) of Gene_expression (expression) of Bcl-XL in liver associated with paracetamol and death
7) Confidence 0.48 Published 1999 Journal Arch. Biochem. Biophys. Section Title Doc Link 10462439 Disease Relevance 0.75 Pain Relevance 0.64
Addition to the culture media of the survival factors present in fetal calf serum (FCS) increased Bcl-xL expression and decreased paracetamol-induced apoptosis.
Positive_regulation (increased) of Gene_expression (expression) of Bcl-xL
8) Confidence 0.48 Published 2005 Journal Kidney Int. Section Body Doc Link 15673306 Disease Relevance 0.08 Pain Relevance 0
The effects of Bcl-xL overexpression, Bax antisense oligodeoxynucleotides, and different caspase inhibitors on cell death were studied.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Bcl-xL
9) Confidence 0.48 Published 2005 Journal Kidney Int. Section Body Doc Link 15673306 Disease Relevance 0.09 Pain Relevance 0
Overexpression of Bcl-2 is observed more frequently than overexpression of Bcl-xL (70% versus 40%) in breast cancer tissue, which suggests a more important role for Bcl-2 in conferring drug resistance.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Bcl-xL associated with breast cancer
10) Confidence 0.44 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.51 Pain Relevance 0
Quantitative measurements of apoptosis, Bax and Bcl-xL protein expression in the ApcMin mice revealed the ratio of Bax/Bcl-xL expression and apoptosis increased in the small intestine but decreased in the cecum, consistent with the regional tumorigenesis observed after sulindac.
Positive_regulation (increased) of Gene_expression (expression) of Bcl-xL in cecum associated with apoptosis
11) Confidence 0.43 Published 2003 Journal Carcinogenesis Section Abstract Doc Link 12663524 Disease Relevance 0.93 Pain Relevance 0.05
This study investigated the effect of AAP on the expression of these oncogenes and whether agents that modulate DNA fragmentation (chlorpromazine, CPZ) and DNA repair through poly(ADP-Ribose) polymerase (PARP) activity (4-AB: 4-aminobenzamide) can protect against AAP-induced hepatotoxicity by inhibiting oxidative stress, DNA fragmentation, and/or by altering the expression of bcl-XL and p53.
Positive_regulation (altering) of Gene_expression (expression) of bcl-XL in poly associated with stress, paracetamol and hepatotoxicity
12) Confidence 0.38 Published 2001 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11461765 Disease Relevance 0.67 Pain Relevance 0.73
Overexpression of a human bcl-xL transgene decreased apoptosis induced by paracetamol by 60% at 24 hours and increased long-term cell survival.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of bcl-xL
13) Confidence 0.35 Published 2005 Journal Kidney Int. Section Body Doc Link 15673306 Disease Relevance 0.07 Pain Relevance 0
Addition to the culture media of the survival factors present in fetal calf serum (FCS) increased Bcl-xL expression and decreased paracetamol-induced apoptosis.
Positive_regulation (increased) of Gene_expression (expression) of Bcl-xL
14) Confidence 0.35 Published 2005 Journal Kidney Int. Section Body Doc Link 15673306 Disease Relevance 0.08 Pain Relevance 0
RESULTS: While paracetamol did not change the mRNA expression of the antiapoptotic gene bcl-xL, it decreased Bcl-xL protein levels.
Neg (not) Positive_regulation (change) of Gene_expression (expression) of bcl-xL
15) Confidence 0.32 Published 2005 Journal Kidney Int. Section Body Doc Link 15673306 Disease Relevance 0.09 Pain Relevance 0
Studies of the phenotypic cell signaling profiles of rituximab sensitive and resistant cell clones demonstrate that rituximab failed to chemosensitize rituximab-resistant clones which exhibited constitutively hyperactivation of NF-kB and ERK1/2 pathways, which leads to overexpression of resistance factors such as Bcl-2, Bcl-xL, and Mcl-1 (Jazirehi et al 2004, 2005, 2007).
Positive_regulation (leads) of Gene_expression (overexpression) of Bcl-xL
16) Confidence 0.26 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721318 Disease Relevance 0.06 Pain Relevance 0
BL cells that had drifted to a lymphoblastic group 3 phenotype were relatively resistant to these actions of serotonin, and the forced ectopic expression of either bcl-2 or bcl-x(L) provided substantial protection from 5-HT-induced apoptosis. 5-HT receptor antagonists (SDZ205-557, granisetron, methysergide) failed to inhibit serotonin-induced apoptosis, whereas the selective serotonin reuptake inhibitors (SSRI)-fluoxetine (Prozac), paroxetine (Paxil), and citalopram (Celexa)-substantially blocked the monoamine actions.
Positive_regulation (forced) of Gene_expression (expression) of bcl-x associated with antagonist, epstein-barr virus, apoptosis, ssri, serotonin, monoamine and fluoxetine
17) Confidence 0.26 Published 2002 Journal Blood Section Abstract Doc Link 11895792 Disease Relevance 1.01 Pain Relevance 0.59
There was constitutive activation of Stat5 and detectable expression of the Stat5 target Bcl-XL in BM of both normal and polycythemic mice, with increased Stat5 phosphorylation and Bcl-XL in spleens from JAKV617F recipients, although this could in part reflect the increase in splenic myeloerythroid cells in these mice.
Positive_regulation (activation) of Gene_expression (expression) of Bcl-XL in spleens
18) Confidence 0.25 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 0.22 Pain Relevance 0
Bcl-xL, which is regulated by both STAT3 Tyr705 and Ser727, is known to be overexpressed in cells resistant to chemotherapy [51,58].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Bcl-xL
19) Confidence 0.19 Published 2008 Journal J Transl Med Section Body Doc Link PMC2267444 Disease Relevance 1.32 Pain Relevance 0
Studies of the phenotypic cell signaling profiles of rituximab sensitive and resistant cell clones demonstrate that rituximab failed to chemosensitize rituximab-resistant clones which exhibited constitutively hyperactivation of NF-kB and ERK1/2 pathways, which leads to overexpression of resistance factors such as Bcl-2, Bcl-xL, and Mcl-1 (Jazirehi et al 2004, 2005, 2007).
Positive_regulation (hyperactivation) of Gene_expression (overexpression) of Bcl-xL
20) Confidence 0.19 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721318 Disease Relevance 0.07 Pain Relevance 0

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