INT83796

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Context Info
Confidence 0.61
First Reported 1999
Last Reported 2008
Negated 3
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 7.85
Pain Relevance 4.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Bcl2l1) cytosol (Bcl2l1) mitochondrion (Bcl2l1)
growth (Bcl2l1) cytoskeleton (Bcl2l1) intracellular (Bcl2l1)
Anatomy Link Frequency
liver 2
Bcl2l1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 78 100.00 Very High Very High Very High
Clonidine 3 99.60 Very High Very High Very High
antagonist 6 93.36 High High
cerebral cortex 2 78.80 Quite High
ischemia 3 50.00 Quite Low
Analgesic 1 25.72 Quite Low
anesthesia 1 10.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 68 100.00 Very High Very High Very High
Hypoxia 13 99.34 Very High Very High Very High
Death 43 98.76 Very High Very High Very High
Hepatotoxicity 7 97.36 Very High Very High Very High
Stress 3 91.36 High High
Nephrotoxicity 1 88.60 High High
Toxicity 7 86.92 High High
Injury 9 82.44 Quite High
Necrosis 12 72.52 Quite High
Cv Unclassified Under Development 3 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the same time period, death inhibitory gene bcl-2 remained unexpressed, and the level of expression of BCL-X(S) remained unaltered.
Regulation (unaltered) of Gene_expression (expression) of BCL-X associated with death
1) Confidence 0.61 Published 2000 Journal Arch. Toxicol. Section Abstract Doc Link 10663392 Disease Relevance 0.99 Pain Relevance 0.45
A hepatotoxic dose of acetaminophen modulates expression of BCL-2, BCL-X(L), and BCL-X(S) during apoptotic and necrotic death of mouse liver cells in vivo.
Regulation (modulates) of Gene_expression (expression) of BCL-X in liver associated with paracetamol, apoptosis and death
2) Confidence 0.45 Published 2000 Journal Arch. Toxicol. Section Title Doc Link 10663392 Disease Relevance 0.86 Pain Relevance 0.45
Unaltered expression of BCL-X(S) in the near total absence of BCL-2 expression raises questions regarding the death promoting role of BCL-X(S) in vivo.
Regulation (Unaltered) of Gene_expression (expression) of BCL-X associated with death
3) Confidence 0.27 Published 2000 Journal Arch. Toxicol. Section Abstract Doc Link 10663392 Disease Relevance 0.83 Pain Relevance 0.45
However, this study may have demonstrated for the first time drug-induced changes in the expression of anti-apoptotic gene BCL-X(L), and a positive link between AAP-induced apoptotic death and modification of BCL-X(L) protein in vivo.
Regulation (changes) of Gene_expression (expression) of BCL-X associated with paracetamol, apoptosis and death
4) Confidence 0.27 Published 2000 Journal Arch. Toxicol. Section Abstract Doc Link 10663392 Disease Relevance 0.94 Pain Relevance 0.38
Whether the consistent level of expression of BCL-X(S) reflected inability of AAP to influence its expression remains unknown.
Regulation (influence) of Gene_expression (expression) of BCL-X associated with paracetamol
5) Confidence 0.27 Published 2000 Journal Arch. Toxicol. Section Abstract Doc Link 10663392 Disease Relevance 0.96 Pain Relevance 0.46
Agarose gel electrophoresis revealed that 7-day GSPE preexposure prior to AAP administration completely blocked Ca(2+)/Mg(2+)-Ca(2+)/Mg(2+)-dependent-endonuclease-mediated ladder-like fragmentation of genomic DNA and significantly altered the bcl-Xl expression.
Regulation (altered) of Gene_expression (expression) of bcl-Xl associated with paracetamol
6) Confidence 0.26 Published 1999 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 10462439 Disease Relevance 0.74 Pain Relevance 0.68
The effect of AAP on bcl-XL was antagonized and that on p53 was synergized by the PARP-modulator 4-AB as well as NICO, whereas the endonuclease inhibitor CPZ was without effect on either bcl-XL or p53 expression.
Neg (without) Regulation (effect) of Gene_expression (expression) of bcl-XL associated with paracetamol
7) Confidence 0.21 Published 2001 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11461765 Disease Relevance 0.51 Pain Relevance 0.83
RESULTS: While paracetamol did not change the mRNA expression of the antiapoptotic gene bcl-xL, it decreased Bcl-xL protein levels.
Neg (not) Regulation (change) of Gene_expression (expression) of bcl-xL
8) Confidence 0.19 Published 2005 Journal Kidney Int. Section Body Doc Link 15673306 Disease Relevance 0.09 Pain Relevance 0
Inhibition of the myocardial apoptotic processes by IPC may involve modulation of the expression of anti-apoptotic proteins, Bcl-2 and Bcl-xL.
Regulation (modulation) of Gene_expression (expression) of Bcl-xL
9) Confidence 0.16 Published 2006 Journal Apoptosis Section Body Doc Link 17051325 Disease Relevance 0.06 Pain Relevance 0
Bax and Bad protein expression increased in all the three compartments during hypoxia, while there was no significant change in the expression of anti-apoptotic proteins Bcl-2 and Bcl-xl.
Neg (no) Regulation (change) of Gene_expression (expression) of Bcl-xl associated with hypoxia and apoptosis
10) Confidence 0.03 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18293086 Disease Relevance 1.87 Pain Relevance 0.35

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